CLEC2D and ENTPD8

Data Source:
BioGRID (two hybrid)

		CLEC2D	ENTPD8
Description		C-type lectin domain family 2 member D	ectonucleoside triphosphate diphosphohydrolase 8
Image			No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane	Plasma Membrane Membrane Integral Component Of Membrane
	Molecular Function	Transmembrane Signaling Receptor Activity Carbohydrate Binding Natural Killer Cell Lectin-like Receptor Binding	Guanosine-diphosphatase Activity ATP Binding Nucleoside-diphosphatase Activity Nucleoside-triphosphatase Activity Uridine-diphosphatase Activity Metal Ion Binding DATP Phosphohydrolase Activity DCTP Phosphohydrolase Activity DUTP Phosphohydrolase Activity DTTP Phosphohydrolase Activity GTP Phosphohydrolase Activity 8-oxo-dGTP Phosphohydrolase Activity DGTP Phosphohydrolase Activity
	Biological Process	Cell Surface Receptor Signaling Pathway Regulation Of Immune Response	Nucleoside Monophosphate Biosynthetic Process Nucleoside Diphosphate Biosynthetic Process Nucleoside Diphosphate Catabolic Process Nucleobase-containing Small Molecule Catabolic Process
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	Phosphate bond hydrolysis by NTPDase proteins
Drugs
Diseases
GWAS		Autoimmune thyroid disease ( 32581359) HDL cholesterol levels x short total sleep time interaction (1df test) ( 31719535) HDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535) Multiple sclerosis ( 31604244)
Interacting Genes		33 interacting genes: - ADIPOQ ATP6V0C B3GALT5 BRICD5 CD68 CLDN19 CLDN2 CLEC2A CLRN2 CXCL9 DEFB121 ENTPD8 ERMP1 FAM3C FNDC9 GPR42 IL1RL1 KLRB1 KLRC1 LEPROTL1 NKG7 PLLP PLN PLP1 RPRM SEC22A SHMT2 SYT15 TM4SF18 TMEM190 TMEM80 TSPAN4	1 interacting genes: CLEC2D
Entrez ID		29121	377841
HPRD ID		16134	16864
Ensembl ID		ENSG00000069493	ENSG00000188833
Uniprot IDs		Q9UHP7 W8JXM2	Q5MY95
PDB IDs		4QKG 4QKH 4QKI 4QKJ 4WCO 5MGT
Enriched GO Terms of Interacting Partners?
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