Wiki-MPM
About
Search
Browse
People
Funding
Updates
Search
GRIN2D and HSPA1A
Data Source:
HPRD
(in vivo)
GRIN2D
HSPA1A
Description
glutamate ionotropic receptor NMDA type subunit 2D
heat shock protein family A (Hsp70) member 1A
Image
No pdb structure
GO Annotations
Cellular Component
Plasma Membrane
Integral Component Of Plasma Membrane
NMDA Selective Glutamate Receptor Complex
Postsynaptic Density Membrane
Extracellular Region
Nucleus
Nucleoplasm
Cytoplasm
Mitochondrion
Endoplasmic Reticulum
Centrosome
Centriole
Cytosol
Plasma Membrane
Focal Adhesion
COP9 Signalosome
Inclusion Body
Aggresome
Nuclear Speck
Vesicle
Protein-containing Complex
Perinuclear Region Of Cytoplasm
Extracellular Exosome
Blood Microparticle
Ficolin-1-rich Granule Lumen
Ribonucleoprotein Complex
Molecular Function
Ionotropic Glutamate Receptor Activity
NMDA Glutamate Receptor Activity
Protein Binding
Ligand-gated Ion Channel Activity
Glutamate-gated Calcium Ion Channel Activity
Signaling Receptor Activity
Virus Receptor Activity
G Protein-coupled Receptor Binding
Transcription Corepressor Activity
RNA Binding
Signaling Receptor Binding
Protein Binding
ATP Binding
ATPase Activity
Enzyme Binding
Heat Shock Protein Binding
Denatured Protein Binding
Ubiquitin Protein Ligase Binding
Histone Deacetylase Binding
Protein Folding Chaperone
Cadherin Binding
Protein N-terminus Binding
Unfolded Protein Binding
Misfolded Protein Binding
C3HC4-type RING Finger Domain Binding
Disordered Domain Specific Binding
Biological Process
Startle Response
Brain Development
Adult Locomotory Behavior
Calcium-mediated Signaling
Ionotropic Glutamate Receptor Signaling Pathway
Regulation Of Synaptic Plasticity
Regulation Of Sensory Perception Of Pain
Excitatory Postsynaptic Potential
Long-term Synaptic Potentiation
Calcium Ion Transmembrane Import Into Cytosol
Excitatory Chemical Synaptic Transmission
MRNA Catabolic Process
Response To Unfolded Protein
Lysosomal Transport
Negative Regulation Of Cell Population Proliferation
Positive Regulation Of Gene Expression
Regulation Of Cell Death
Vesicle-mediated Transport
Negative Regulation Of Cell Growth
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Regulation Of Protein Ubiquitination
Negative Regulation Of Protein Ubiquitination
Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Interleukin-8 Production
Positive Regulation Of RNA Splicing
Cellular Response To Oxidative Stress
Cellular Response To Heat
Cellular Response To Unfolded Protein
Protein Refolding
Negative Regulation Of Apoptotic Process
Neutrophil Degranulation
Regulation Of MRNA Stability
Positive Regulation Of Erythrocyte Differentiation
ATP Metabolic Process
Viral Entry Into Host Cell
Protein Stabilization
Chaperone Cofactor-dependent Protein Refolding
Positive Regulation Of NF-kappaB Transcription Factor Activity
Chaperone-mediated Protein Complex Assembly
Negative Regulation Of Cell Death
Cellular Heat Acclimation
Positive Regulation Of Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway
Positive Regulation Of Microtubule Nucleation
Negative Regulation Of Inclusion Body Assembly
Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress
Regulation Of Cellular Response To Heat
Negative Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway
Regulation Of Mitotic Spindle Assembly
Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway
Positive Regulation Of Endoribonuclease Activity
Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways
Unblocking of NMDA receptors, glutamate binding and activation
Unblocking of NMDA receptors, glutamate binding and activation
Ras activation upon Ca2+ influx through NMDA receptor
RAF/MAP kinase cascade
Neurexins and neuroligins
Synaptic adhesion-like molecules
Assembly and cell surface presentation of NMDA receptors
Assembly and cell surface presentation of NMDA receptors
Negative regulation of NMDA receptor-mediated neuronal transmission
Long-term potentiation
Viral RNP Complexes in the Host Cell Nucleus
Regulation of HSF1-mediated heat shock response
HSP90 chaperone cycle for steroid hormone receptors (SHR)
Attenuation phase
HSF1-dependent transactivation
AUF1 (hnRNP D0) binds and destabilizes mRNA
Neutrophil degranulation
Regulation of HSF1-mediated heat shock response
HSP90 chaperone cycle for steroid hormone receptors (SHR)
Attenuation phase
HSF1-dependent transactivation
Neutrophil degranulation
Drugs
Glutamic acid
Tramadol
Enflurane
Atomoxetine
Pentobarbital
Methadone
Secobarbital
Meperidine
Acamprosate
Donepezil
Guaifenesin
Memantine
Orphenadrine
Phenobarbital
Aripiprazole
Tenocyclidine
Prasterone
Milnacipran
Acetylcysteine
Ketobemidone
Gavestinel
Magnesium acetate tetrahydrate
Magnesium carbonate
Esketamine
Fluciclovine (18F)
Diseases
GWAS
Asthma (
31619474
)
Asthma (childhood onset) (
31619474
)
Asthma and major depressive disorder (
31619474
)
Autism spectrum disorder or schizophrenia (
28540026
)
Blood protein levels (
28240269
)
Inflammatory bowel disease (
28067908
)
Schizophrenia (
30285260
)
Ulcerative colitis (
28067908
)
Interacting Genes
33 interacting genes:
ABL1
CDH2
CIT
CLTC
CTNNB1
DLG2
DLG4
DLGAP4
DNM1
DUSP4
FUS
GRIN1
HNRNPU
HRAS
HSPA1A
IL16
INA
MAP2
MAP2K2
NANOS1
NF1
PATJ
PPP2R1A
PPP2R2A
PRKCB
PRKCE
PRKCG
RAP2A
RPS6KA3
SPTAN1
SYNGAP1
TJP1
TRAF3
88 interacting genes:
AIFM1
AIMP2
APAF1
APEX1
APOB
ATXN1
BAG1
BAG2
BAG3
BAG4
BCL2
BRSK1
CACNA1E
CDK9
CFAP52
DAPP1
DNAAF4
DNAJA2
DNAJA3
DNAJB1
DNAJB11
DNAJC3
EGFR
EIF2AK2
ERBB2
ERBB3
FANCC
FOS
GPR37
GRIN1
GRIN2D
HAP1
HCFC1
HEMGN
HIVEP1
HMGA1
HSBP1
HSF1
HSPA8
HSPBP1
IKBKG
INS
KRT18
KRT7
MAP3K5
MAPRE1
METTL21A
MOS
MSR1
NQO1
NR3C1
PEX5
PGR
PLG
POT1
PPP1R15A
PRKCA
PSMC5
PTGES3
PTMA
PTPRF
RAP1A
RAPGEF2
RHOA
SAE1
SLC13A1
SLC5A1
SNCB
SNRK
SOX9
ST13
STIP1
STUB1
SUMO2
TCERG1
TGM2
TOMM70
TP53
TRIAP1
TRIM24
TRIM38
TSSK6
TTC1
XIAP
YWHAB
YWHAG
YWHAQ
YWHAZ
Entrez ID
2906
3303
HPRD ID
04095
00774
Ensembl ID
ENSG00000105464
ENSG00000204389
Uniprot IDs
O15399
Q59G17
A8K5I0
B3KTT5
P0DMV8
P0DMV9
PDB IDs
1HJO
1S3X
1XQS
2E88
2E8A
2LMG
3A8Y
3ATU
3ATV
3AY9
3D2E
3D2F
3JXU
3LOF
3Q49
4IO8
4J8F
4PO2
4WV5
4WV7
5AQW
5AQX
5AQY
5AQZ
5AR0
5BN8
5BN9
5BPL
5BPM
5BPN
5GJJ
5MKR
5MKS
5XI9
5XIR
6FDT
6FHK
6G3R
6G3S
6JPV
6K39
Enriched GO Terms of Interacting Partners
?
Tagcloud
?
Tagcloud (Difference)
?
Tagcloud (Intersection)
?