GRIN2D and CTNNB1

Data Source:
HPRD (in vivo)

		GRIN2D	CTNNB1
Description		glutamate ionotropic receptor NMDA type subunit 2D	catenin beta 1
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane NMDA Selective Glutamate Receptor Complex Postsynaptic Density Membrane	Euchromatin Spindle Pole Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Centrosome Cytosol Plasma Membrane Cell-cell Junction Adherens Junction Focal Adhesion Cell Cortex Membrane Basolateral Plasma Membrane Lateral Plasma Membrane Catenin Complex Cell Junction Beta-catenin Destruction Complex Protein-containing Complex Protein-DNA Complex Cell Projection Synapse Perinuclear Region Of Cytoplasm Extracellular Exosome Beta-catenin-TCF7L2 Complex Cell Periphery Beta-catenin-TCF Complex Wnt Signalosome
	Molecular Function	Ionotropic Glutamate Receptor Activity NMDA Glutamate Receptor Activity Protein Binding Ligand-gated Ion Channel Activity Glutamate-gated Calcium Ion Channel Activity Signaling Receptor Activity	RNA Polymerase II Transcription Factor Binding RNA Polymerase II Activating Transcription Factor Binding Chromatin Binding Transcription Coactivator Activity Protein Binding Beta-catenin Binding Protein C-terminus Binding Transcription Factor Binding Enzyme Binding Kinase Binding Protein Phosphatase Binding Estrogen Receptor Binding Nuclear Hormone Receptor Binding Ion Channel Binding Alpha-catenin Binding Cadherin Binding SMAD Binding I-SMAD Binding
	Biological Process	Startle Response Brain Development Adult Locomotory Behavior Calcium-mediated Signaling Ionotropic Glutamate Receptor Signaling Pathway Regulation Of Synaptic Plasticity Regulation Of Sensory Perception Of Pain Excitatory Postsynaptic Potential Long-term Synaptic Potentiation Calcium Ion Transmembrane Import Into Cytosol Excitatory Chemical Synaptic Transmission	Protein Polyubiquitination Branching Involved In Blood Vessel Morphogenesis Epithelial To Mesenchymal Transition Positive Regulation Of Neuroblast Proliferation Cell Adhesion Wnt Signaling Pathway, Calcium Modulating Pathway Negative Regulation Of Cell Population Proliferation Positive Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Heparan Sulfate Proteoglycan Biosynthetic Process Viral Process Wnt Signaling Pathway Negative Regulation Of Angiogenesis Stem Cell Population Maintenance Regulation Of Centriole-centriole Cohesion Response To Estradiol Positive Regulation Of Type I Interferon Production Negative Regulation Of Protein Sumoylation Adherens Junction Assembly Protein Localization To Cell Surface Hair Cell Differentiation Entry Of Bacterium Into Host Cell Detection Of Muscle Stretch Embryonic Skeletal Limb Joint Morphogenesis Response To Drug Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Neuron Apoptotic Process Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Epithelial To Mesenchymal Transition Canonical Wnt Signaling Pathway Involved In Negative Regulation Of Apoptotic Process Regulation Of Angiogenesis Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Mitotic Cell Cycle, Embryonic Regulation Of Fibroblast Proliferation Regulation Of Smooth Muscle Cell Proliferation Regulation Of Neurogenesis Positive Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Muscle Cell Differentiation Positive Regulation Of Histone H3-K4 Methylation Canonical Wnt Signaling Pathway Regulation Of Canonical Wnt Signaling Pathway Endothelial Tube Morphogenesis Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Cardiac Outflow Tract Cell Proliferation Sympathetic Ganglion Development Regulation Of Centromeric Sister Chromatid Cohesion Cellular Response To Growth Factor Stimulus Cellular Response To Indole-3-methanol Regulation Of Nephron Tubule Epithelial Cell Differentiation Regulation Of Calcium Ion Import Cell-cell Adhesion Positive Regulation Of Core Promoter Binding Beta-catenin-TCF Complex Assembly Beta-catenin Destruction Complex Disassembly Midbrain Dopaminergic Neuron Differentiation Canonical Wnt Signaling Pathway Involved In Midbrain Dopaminergic Neuron Differentiation Neuron Projection Extension Regulation Of Protein Localization To Cell Surface Positive Regulation Of DNA-templated Transcription, Initiation
Pathways		Unblocking of NMDA receptors, glutamate binding and activation Unblocking of NMDA receptors, glutamate binding and activation Ras activation upon Ca2+ influx through NMDA receptor RAF/MAP kinase cascade Neurexins and neuroligins Synaptic adhesion-like molecules Assembly and cell surface presentation of NMDA receptors Assembly and cell surface presentation of NMDA receptors Negative regulation of NMDA receptor-mediated neuronal transmission Long-term potentiation	Degradation of beta-catenin by the destruction complex Beta-catenin phosphorylation cascade TCF dependent signaling in response to WNT Formation of the beta-catenin:TCF transactivating complex Formation of the beta-catenin:TCF transactivating complex LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production Apoptotic cleavage of cell adhesion proteins Deactivation of the beta-catenin transactivating complex Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) Ca2+ pathway Adherens junctions interactions Binding of TCF/LEF:CTNNB1 to target gene promoters Disassembly of the destruction complex and recruitment of AXIN to the membrane Disassembly of the destruction complex and recruitment of AXIN to the membrane VEGFR2 mediated vascular permeability Myogenesis Myogenesis Signaling by GSK3beta mutants S33 mutants of beta-catenin aren't phosphorylated S37 mutants of beta-catenin aren't phosphorylated S45 mutants of beta-catenin aren't phosphorylated T41 mutants of beta-catenin aren't phosphorylated RHO GTPases activate IQGAPs Transcriptional Regulation by VENTX InlA-mediated entry of Listeria monocytogenes into host cells RUNX3 regulates WNT signaling
Drugs		Glutamic acid Tramadol Enflurane Atomoxetine Pentobarbital Methadone Secobarbital Meperidine Acamprosate Donepezil Guaifenesin Memantine Orphenadrine Phenobarbital Aripiprazole Tenocyclidine Prasterone Milnacipran Acetylcysteine Ketobemidone Gavestinel Magnesium acetate tetrahydrate Magnesium carbonate Esketamine Fluciclovine (18F)	Urea
Diseases			Gastric cancer Colorectal cancer Endometrial Cancer Pilomatricoma; Epithelioma calcificans of Malherbe Thyroid cancer Hepatocellular carcinoma
GWAS			Bone mineral density (hip) ( 27311723 19801982) Bone mineral density (total hip) ( 29883787) Colorectal cancer ( 26151821) Colorectal cancer or advanced adenoma ( 30510241) Femoral neck bone mineral density ( 29499414 22504420) Fractures ( 30158200) Heel bone mineral density ( 30598549 28869591) High myopia ( 31816047) Lumbar spine bone mineral density ( 29499414) Refractive error ( 32231278) Systolic blood pressure ( 30224653)
Interacting Genes		33 interacting genes: ABL1 CDH2 CIT CLTC CTNNB1 DLG2 DLG4 DLGAP4 DNM1 DUSP4 FUS GRIN1 HNRNPU HRAS HSPA1A IL16 INA MAP2 MAP2K2 NANOS1 NF1 PATJ PPP2R1A PPP2R2A PRKCB PRKCE PRKCG RAP2A RPS6KA3 SPTAN1 SYNGAP1 TJP1 TRAF3	187 interacting genes: ACP1 AJAP1 AKT1 AMER1 APC APC2 APP AR ARFGEF1 ARHGAP32 ASH2L AXIN1 AXIN2 BCL3 BCL6 BCL9 BCL9L BOC BRCA1 BTRC CA9 CARM1 CASP3 CASP8 CBL CBY1 CCND1 CDC27 CDC34 CDC73 CDH1 CDH11 CDH15 CDH16 CDH2 CDH24 CDH3 CDH5 CDH7 CDH8 CDH9 CDK2 CDK5R1 CDK6 CDON CEBPA CHD8 CHUK CREBBP CSNK1A1 CSNK1D CSNK2A1 CSNK2B CTNNA1 CTNNA3 CTNNBIP1 CTNND2 DLG5 DSC3 DVL1 DVL3 EGFR ELAVL1 EP300 ERBB2 ERBIN ESR1 EZR FBXW2 FER FHIT FHL2 FLT1 FOXO1 FOXO4 FSCN1 FUS FYN GLIS2 GNA13 GRIK2 GRIN1 GRIN2D GSK3B H1-2 HIF1A HNF1A HUWE1 IGF2BP1 IKBKB IQGAP1 JADE1 KAT2A KAT2B KDR KMT2A KMT2D LATS2 LEF1 LEO1 MAGI1 MAGI2 MAP3K2 MAPK8 MAPK9 MEN1 MET MITF MUC1 NCOA2 NDRG1 NEK2 NEURL2 NF2 NFKB1 NOTCH1 NR5A1 PECAM1 PICK1 PIK3R1 PIN1 PITX2 PKD1 PKM PKP2 PLK1 PPM1A PRKCG PSEN1 PSEN2 PTGS2 PTPN1 PTPN13 PTPN14 PTPN6 PTPRF PTPRJ PTPRK PTPRM PTPRU PTPRZ1 PYGO1 RAPGEF2 RBBP5 RUVBL1 RUVBL2 RXRA SALL1 SLC9A3R1 SMAD2 SMAD3 SMAD4 SMAD7 SMARCA4 SMARCA5 SMURF1 SOX1 SOX17 SP1 SPN SRC STUB1 TAX1BP3 TBL1X TCF3 TCF4 TCF7L1 TCF7L2 TFAP2A TGFBR1 TGFBR2 TLE1 TRIM33 TRIM55 TRIM63 TRIP10 TRRAP UBE2B UBE2D1 UBE2R2 UBE2S UBE3A UHRF2 USP2 USP9X ZFYVE9 ZIC3
Entrez ID		2906	1499
HPRD ID		04095	00286
Ensembl ID		ENSG00000105464	ENSG00000168036
Uniprot IDs		O15399 Q59G17	A0A024R2Q3 B4DGU4 P35222
PDB IDs			1G3J 1JDH 1JPW 1LUJ 1P22 1QZ7 1T08 1TH1 2G57 2GL7 2Z6H 3DIW 3FQN 3FQR 3SL9 3SLA 3TX7 4DJS 6M90 6M91 6M92 6M93 6M94 6O9B 6O9C 6WLX 6WNX
Enriched GO Terms of Interacting Partners?
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