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GRIN2D and DUSP4
Data Source:
HPRD
(in vivo)
GRIN2D
DUSP4
Description
glutamate ionotropic receptor NMDA type subunit 2D
dual specificity phosphatase 4
Image
No pdb structure
GO Annotations
Cellular Component
Plasma Membrane
Integral Component Of Plasma Membrane
NMDA Selective Glutamate Receptor Complex
Postsynaptic Density Membrane
Nucleus
Nucleoplasm
Cytoplasm
Molecular Function
Ionotropic Glutamate Receptor Activity
NMDA Glutamate Receptor Activity
Protein Binding
Ligand-gated Ion Channel Activity
Glutamate-gated Calcium Ion Channel Activity
Signaling Receptor Activity
Phosphoprotein Phosphatase Activity
Protein Tyrosine Phosphatase Activity
Protein Binding
Protein Tyrosine/threonine Phosphatase Activity
Phosphatase Activity
MAP Kinase Tyrosine/serine/threonine Phosphatase Activity
Mitogen-activated Protein Kinase Binding
Protein Serine Phosphatase Activity
Protein Threonine Phosphatase Activity
MAP Kinase Serine/threonine Phosphatase Activity
Biological Process
Startle Response
Brain Development
Adult Locomotory Behavior
Calcium-mediated Signaling
Ionotropic Glutamate Receptor Signaling Pathway
Regulation Of Synaptic Plasticity
Regulation Of Sensory Perception Of Pain
Excitatory Postsynaptic Potential
Long-term Synaptic Potentiation
Calcium Ion Transmembrane Import Into Cytosol
Excitatory Chemical Synaptic Transmission
Inactivation Of MAPK Activity
Endoderm Formation
Protein Dephosphorylation
Dephosphorylation
Peptidyl-tyrosine Dephosphorylation
Peptidyl-threonine Dephosphorylation
Negative Regulation Of ERK1 And ERK2 Cascade
Pathways
Unblocking of NMDA receptors, glutamate binding and activation
Unblocking of NMDA receptors, glutamate binding and activation
Ras activation upon Ca2+ influx through NMDA receptor
RAF/MAP kinase cascade
Neurexins and neuroligins
Synaptic adhesion-like molecules
Assembly and cell surface presentation of NMDA receptors
Assembly and cell surface presentation of NMDA receptors
Negative regulation of NMDA receptor-mediated neuronal transmission
Long-term potentiation
RAF-independent MAPK1/3 activation
ERKs are inactivated
Negative regulation of MAPK pathway
Drugs
Glutamic acid
Tramadol
Enflurane
Atomoxetine
Pentobarbital
Methadone
Secobarbital
Meperidine
Acamprosate
Donepezil
Guaifenesin
Memantine
Orphenadrine
Phenobarbital
Aripiprazole
Tenocyclidine
Prasterone
Milnacipran
Acetylcysteine
Ketobemidone
Gavestinel
Magnesium acetate tetrahydrate
Magnesium carbonate
Esketamine
Fluciclovine (18F)
Diseases
GWAS
Gestational age at birth (maternal effect) (
28598419
)
Postoperative complication after cardiac surgery (
30678657
)
Response to statin therapy (
20339536
)
Spontaneous preterm birth (maternal effect) (
28598419
)
Interacting Genes
33 interacting genes:
ABL1
CDH2
CIT
CLTC
CTNNB1
DLG2
DLG4
DLGAP4
DNM1
DUSP4
FUS
GRIN1
HNRNPU
HRAS
HSPA1A
IL16
INA
MAP2
MAP2K2
NANOS1
NF1
PATJ
PPP2R1A
PPP2R2A
PRKCB
PRKCE
PRKCG
RAP2A
RPS6KA3
SPTAN1
SYNGAP1
TJP1
TRAF3
19 interacting genes:
APP
CRMP1
GORASP2
GRIN1
GRIN2D
LYSMD1
LYSMD2
LZTS2
MAPK1
MAPK14
MAPK3
MAPK8
MAPK9
NOXA1
PLEKHF2
TEPSIN
TRAF1
ZNF426
ZNF655
Entrez ID
2906
1846
HPRD ID
04095
04123
Ensembl ID
ENSG00000105464
ENSG00000120875
Uniprot IDs
O15399
Q59G17
Q13115
PDB IDs
3EZZ
Enriched GO Terms of Interacting Partners
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Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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