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GRIN2D and FUS
Data Source:
HPRD
(in vivo)
GRIN2D
FUS
Description
glutamate ionotropic receptor NMDA type subunit 2D
FUS RNA binding protein
Image
No pdb structure
GO Annotations
Cellular Component
Plasma Membrane
Integral Component Of Plasma Membrane
NMDA Selective Glutamate Receptor Complex
Postsynaptic Density Membrane
Nucleus
Nucleoplasm
Molecular Function
Ionotropic Glutamate Receptor Activity
NMDA Glutamate Receptor Activity
Protein Binding
Ligand-gated Ion Channel Activity
Glutamate-gated Calcium Ion Channel Activity
Signaling Receptor Activity
DNA Binding
Chromatin Binding
Transcription Coregulator Activity
Transcription Coactivator Activity
RNA Binding
Protein Binding
Identical Protein Binding
Metal Ion Binding
Biological Process
Startle Response
Brain Development
Adult Locomotory Behavior
Calcium-mediated Signaling
Ionotropic Glutamate Receptor Signaling Pathway
Regulation Of Synaptic Plasticity
Regulation Of Sensory Perception Of Pain
Excitatory Postsynaptic Potential
Long-term Synaptic Potentiation
Calcium Ion Transmembrane Import Into Cytosol
Excitatory Chemical Synaptic Transmission
MRNA Splicing, Via Spliceosome
Regulation Of Transcription, DNA-templated
Regulation Of Transcription By RNA Polymerase II
RNA Splicing
Regulation Of RNA Splicing
Positive Regulation Of Transcription, DNA-templated
MRNA Stabilization
Protein Homooligomerization
Positive Regulation Of Double-strand Break Repair Via Homologous Recombination
Pathways
Unblocking of NMDA receptors, glutamate binding and activation
Unblocking of NMDA receptors, glutamate binding and activation
Ras activation upon Ca2+ influx through NMDA receptor
RAF/MAP kinase cascade
Neurexins and neuroligins
Synaptic adhesion-like molecules
Assembly and cell surface presentation of NMDA receptors
Assembly and cell surface presentation of NMDA receptors
Negative regulation of NMDA receptor-mediated neuronal transmission
Long-term potentiation
mRNA Splicing - Major Pathway
Drugs
Glutamic acid
Tramadol
Enflurane
Atomoxetine
Pentobarbital
Methadone
Secobarbital
Meperidine
Acamprosate
Donepezil
Guaifenesin
Memantine
Orphenadrine
Phenobarbital
Aripiprazole
Tenocyclidine
Prasterone
Milnacipran
Acetylcysteine
Ketobemidone
Gavestinel
Magnesium acetate tetrahydrate
Magnesium carbonate
Esketamine
Fluciclovine (18F)
Diseases
Amyotrophic lateral sclerosis (ALS); Lou Gehrig's disease
Myxoid liposarcoma
GWAS
Bipolar disorder (
31043756
)
Bipolar I disorder (
31043756
)
HDL cholesterol levels (
32203549
)
Interacting Genes
33 interacting genes:
ABL1
CDH2
CIT
CLTC
CTNNB1
DLG2
DLG4
DLGAP4
DNM1
DUSP4
FUS
GRIN1
HNRNPU
HRAS
HSPA1A
IL16
INA
MAP2
MAP2K2
NANOS1
NF1
PATJ
PPP2R1A
PPP2R2A
PRKCB
PRKCE
PRKCG
RAP2A
RPS6KA3
SPTAN1
SYNGAP1
TJP1
TRAF3
117 interacting genes:
ADAMTS9-AS2
AKT1
ARID1A
ATXN1L
CTNNB1
ESRRA
EWSR1
GRIN1
GRIN2D
IL7R
ILF3
KHDRBS3
MAX
MDH1
MIR1-1
MIR1-2
MIR106A
MIR106B
MIR107
MIR10B
MIR122
MIR128-1
MIR128-2
MIR138-1
MIR138-2
MIR140
MIR141
MIR143
MIR145
MIR155
MIR15A
MIR15B
MIR16-1
MIR16-2
MIR17
MIR18A
MIR18B
MIR199A1
MIR199A2
MIR19A
MIR19B1
MIR19B2
MIR200A
MIR200B
MIR200C
MIR205
MIR206
MIR20A
MIR20B
MIR21
MIR214
MIR221
MIR222
MIR25
MIR29A
MIR29B1
MIR29B2
MIR29C
MIR31
MIR34A
MIR34B
MIR34C
MIR363
MIR429
MIR451A
MIR7-1
MIR7-2
MIR7-3
MIR9-1
MIR9-2
MIR9-3
MIR92A1
MIR92A2
MIR93
MIR98
MIRLET7A1
MIRLET7A2
MIRLET7A3
MIRLET7B
MIRLET7C
MIRLET7D
MIRLET7E
MIRLET7F1
MIRLET7F2
MIRLET7G
MIRLET7I
NKD2
POLR2A
PRMT1
PSMB7
PTBP1
RBMX
RELA
RXRA
SAFB2
SF1
SFPQ
SMARCB1
SMARCC1
SMARCC2
SMARCD1
SPI1
SRRM1
SRSF10
SRSF2
SRSF4
SRSF9
SS18
SUV39H1
TARDBP
TDRD3
THRA
TNIP1
UBQLN2
WBP4
YBX1
ZMYM2
Entrez ID
2906
2521
HPRD ID
04095
00660
Ensembl ID
ENSG00000105464
ENSG00000089280
Uniprot IDs
O15399
Q59G17
P35637
Q13344
Q6IBQ5
PDB IDs
2LA6
2LCW
4FDD
4FQ3
5W3N
5XRR
5XSG
5YVG
5YVH
5YVI
6BWZ
6BXV
6BZP
6G99
6GBM
6KJ1
6KJ2
6KJ3
6KJ4
6SNJ
6XFM
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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