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GRIN2D and DLG4
Data Source:
HPRD
(in vitro, two hybrid, in vivo)
GRIN2D
DLG4
Description
glutamate ionotropic receptor NMDA type subunit 2D
discs large MAGUK scaffold protein 4
Image
No pdb structure
GO Annotations
Cellular Component
Plasma Membrane
Integral Component Of Plasma Membrane
NMDA Selective Glutamate Receptor Complex
Postsynaptic Density Membrane
Cytoplasm
Endoplasmic Reticulum
Cytosol
Plasma Membrane
Synaptic Vesicle
Voltage-gated Potassium Channel Complex
Ionotropic Glutamate Receptor Complex
Postsynaptic Density
Cell Junction
Endocytic Vesicle Membrane
Cortical Cytoskeleton
Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane
Neuromuscular Junction
AMPA Glutamate Receptor Complex
Dendrite Cytoplasm
Neuron Projection
Dendritic Spine
Juxtaparanode Region Of Axon
Cerebellar Mossy Fiber
Neuron Projection Terminus
Neuron Spine
Synapse
Postsynaptic Membrane
Excitatory Synapse
Synaptic Membrane
Postsynaptic Density Membrane
Glutamatergic Synapse
Molecular Function
Ionotropic Glutamate Receptor Activity
NMDA Glutamate Receptor Activity
Protein Binding
Ligand-gated Ion Channel Activity
Glutamate-gated Calcium Ion Channel Activity
Signaling Receptor Activity
Protein Binding
Protein C-terminus Binding
Kinase Binding
Protein Phosphatase Binding
PDZ Domain Binding
Beta-1 Adrenergic Receptor Binding
D1 Dopamine Receptor Binding
P2Y1 Nucleotide Receptor Binding
Acetylcholine Receptor Binding
Ionotropic Glutamate Receptor Binding
Protein-containing Complex Binding
Neuroligin Family Protein Binding
Scaffold Protein Binding
Biological Process
Startle Response
Brain Development
Adult Locomotory Behavior
Calcium-mediated Signaling
Ionotropic Glutamate Receptor Signaling Pathway
Regulation Of Synaptic Plasticity
Regulation Of Sensory Perception Of Pain
Excitatory Postsynaptic Potential
Long-term Synaptic Potentiation
Calcium Ion Transmembrane Import Into Cytosol
Excitatory Chemical Synaptic Transmission
MAPK Cascade
Negative Regulation Of Receptor Internalization
Signal Transduction
Positive Regulation Of Cytosolic Calcium Ion Concentration
Chemical Synaptic Transmission
Nervous System Development
Learning
Synaptic Vesicle Maturation
Social Behavior
Protein Localization To Synapse
Locomotory Exploration Behavior
Cellular Response To Potassium Ion
Receptor Clustering
Establishment Of Protein Localization
Regulation Of Long-term Neuronal Synaptic Plasticity
Positive Regulation Of Synaptic Transmission
Neuromuscular Process Controlling Balance
Dendritic Spine Morphogenesis
Positive Regulation Of Protein Tyrosine Kinase Activity
Protein-containing Complex Assembly
Vocalization Behavior
AMPA Glutamate Receptor Clustering
Receptor Localization To Synapse
Cell-cell Adhesion
Postsynaptic Neurotransmitter Receptor Diffusion Trapping
Positive Regulation Of Neuron Projection Arborization
Regulation Of NMDA Receptor Activity
Positive Regulation Of Excitatory Postsynaptic Potential
Regulation Of Grooming Behavior
Pathways
Unblocking of NMDA receptors, glutamate binding and activation
Unblocking of NMDA receptors, glutamate binding and activation
Ras activation upon Ca2+ influx through NMDA receptor
RAF/MAP kinase cascade
Neurexins and neuroligins
Synaptic adhesion-like molecules
Assembly and cell surface presentation of NMDA receptors
Assembly and cell surface presentation of NMDA receptors
Negative regulation of NMDA receptor-mediated neuronal transmission
Long-term potentiation
Signaling by ERBB4
Trafficking of AMPA receptors
Unblocking of NMDA receptors, glutamate binding and activation
Unblocking of NMDA receptors, glutamate binding and activation
Ras activation upon Ca2+ influx through NMDA receptor
NrCAM interactions
Activation of Ca-permeable Kainate Receptor
RHO GTPases activate CIT
RAF/MAP kinase cascade
LGI-ADAM interactions
Neurexins and neuroligins
Neurexins and neuroligins
Synaptic adhesion-like molecules
Assembly and cell surface presentation of NMDA receptors
Negative regulation of NMDA receptor-mediated neuronal transmission
Long-term potentiation
Drugs
Glutamic acid
Tramadol
Enflurane
Atomoxetine
Pentobarbital
Methadone
Secobarbital
Meperidine
Acamprosate
Donepezil
Guaifenesin
Memantine
Orphenadrine
Phenobarbital
Aripiprazole
Tenocyclidine
Prasterone
Milnacipran
Acetylcysteine
Ketobemidone
Gavestinel
Magnesium acetate tetrahydrate
Magnesium carbonate
Esketamine
Fluciclovine (18F)
Guanidine
Guanosine-5'-Monophosphate
Diseases
GWAS
Cholesterol, total (
24097068
25961943
)
Hematocrit (
32888494
)
Hemoglobin (
32888494
)
LDL cholesterol (
24097068
25961943
)
LDL cholesterol levels (
28334899
)
Liver enzyme levels (alkaline phosphatase) (
22001757
)
Serum alkaline phosphatase levels (
29403010
)
Interacting Genes
33 interacting genes:
ABL1
CDH2
CIT
CLTC
CTNNB1
DLG2
DLG4
DLGAP4
DNM1
DUSP4
FUS
GRIN1
HNRNPU
HRAS
HSPA1A
IL16
INA
MAP2
MAP2K2
NANOS1
NF1
PATJ
PPP2R1A
PPP2R2A
PRKCB
PRKCE
PRKCG
RAP2A
RPS6KA3
SPTAN1
SYNGAP1
TJP1
TRAF3
109 interacting genes:
ACTN2
ADGRB1
ADGRL1
ADRB1
AKAP5
ARHGAP32
ARRB2
ASIC3
ATP2B2
ATP2B4
BEGAIN
CACNG2
CASK
CD46
CIT
CNKSR2
CRHR1
CRIPT
CYLD
DLG2
DLG3
DLGAP1
DLGAP2
DLGAP3
DLGAP4
DYNLL1
EFNB2
ERBB2
ERBB4
ERBIN
EXOC4
FYN
FZD1
FZD2
FZD4
FZD7
GDA
GLS2
GNG13
GRIK1
GRIK2
GRIK5
GRIN1
GRIN2A
GRIN2B
GRIN2C
GRIN2D
GRIN3A
GRIN3B
GUCY1A2
HGS
HTR2A
HTR2C
HTT
IL13RA1
KCNA1
KCNA2
KCNA3
KCNA4
KCNA5
KCND2
KCNJ10
KCNJ12
KCNJ2
KCNJ4
KHDRBS1
KIF13B
KIF1B
LIN7A
LIN7B
LRFN1
LRP1
LRP2
LRP8
LRRC1
LYN
MAP1A
MAP3K10
MAPK12
MDM2
NCKIPSD
NDOR1
NLGN1
NLGN2
NLGN3
NLGN4X
NOS1
PCDH10
PRKCA
PTK2B
PTPRG
RPS6KA1
SCN5A
SEMA4B
SEMA4C
SEMA4F
SEMA4G
SHANK1
SHANK2
SIPA1L1
SPRR2A
SRC
SYNGAP1
TAMALIN
TANC1
TRAF6
WNT3A
YES1
ZDHHC17
Entrez ID
2906
1742
HPRD ID
04095
04199
Ensembl ID
ENSG00000105464
ENSG00000132535
Uniprot IDs
O15399
Q59G17
B7Z4H2
B7Z647
B9EGL1
P78352
PDB IDs
1KEF
2MES
3I4W
3K82
3ZRT
5J7J
5JXB
6QJD
6QJF
6QJG
6QJI
6QJJ
6QJK
6QJL
6QJN
6SPV
6SPZ
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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