HSPA1A and PSMC5

Data Source:
BioGRID (pull down)

		HSPA1A	PSMC5
Description		heat shock protein family A (Hsp70) member 1A	proteasome 26S subunit, ATPase 5
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GO Annotations	Cellular Component	Extracellular Region Nucleus Nucleoplasm Cytoplasm Mitochondrion Endoplasmic Reticulum Centrosome Centriole Cytosol Plasma Membrane Focal Adhesion COP9 Signalosome Inclusion Body Aggresome Nuclear Speck Vesicle Protein-containing Complex Perinuclear Region Of Cytoplasm Extracellular Exosome Blood Microparticle Ficolin-1-rich Granule Lumen Ribonucleoprotein Complex	Proteasome Complex Nucleus Nucleoplasm Cytoplasm Cytosol Proteasome Regulatory Particle, Base Subcomplex Membrane Inclusion Body Proteasome Accessory Complex Cytoplasmic Vesicle Nuclear Proteasome Complex Cytosolic Proteasome Complex Extracellular Exosome Blood Microparticle Postsynapse
	Molecular Function	Virus Receptor Activity G Protein-coupled Receptor Binding Transcription Corepressor Activity RNA Binding Signaling Receptor Binding Protein Binding ATP Binding ATPase Activity Enzyme Binding Heat Shock Protein Binding Denatured Protein Binding Ubiquitin Protein Ligase Binding Histone Deacetylase Binding Protein Folding Chaperone Cadherin Binding Protein N-terminus Binding Unfolded Protein Binding Misfolded Protein Binding C3HC4-type RING Finger Domain Binding Disordered Domain Specific Binding	Protein Binding ATP Binding Transcription Factor Binding ATPase Activity TBP-class Protein Binding Thyrotropin-releasing Hormone Receptor Binding
	Biological Process	MRNA Catabolic Process Response To Unfolded Protein Lysosomal Transport Negative Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Regulation Of Cell Death Vesicle-mediated Transport Negative Regulation Of Cell Growth Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Protein Ubiquitination Negative Regulation Of Protein Ubiquitination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Interleukin-8 Production Positive Regulation Of RNA Splicing Cellular Response To Oxidative Stress Cellular Response To Heat Cellular Response To Unfolded Protein Protein Refolding Negative Regulation Of Apoptotic Process Neutrophil Degranulation Regulation Of MRNA Stability Positive Regulation Of Erythrocyte Differentiation ATP Metabolic Process Viral Entry Into Host Cell Protein Stabilization Chaperone Cofactor-dependent Protein Refolding Positive Regulation Of NF-kappaB Transcription Factor Activity Chaperone-mediated Protein Complex Assembly Negative Regulation Of Cell Death Cellular Heat Acclimation Positive Regulation Of Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Positive Regulation Of Microtubule Nucleation Negative Regulation Of Inclusion Body Assembly Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of Cellular Response To Heat Negative Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Mitotic Spindle Assembly Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Endoribonuclease Activity Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	MAPK Cascade Protein Polyubiquitination Stimulatory C-type Lectin Receptor Signaling Pathway Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Regulation Of Transcription By RNA Polymerase II Regulation Of Cellular Amino Acid Metabolic Process Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Protein Deubiquitination Anaphase-promoting Complex-dependent Catabolic Process SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Tumor Necrosis Factor-mediated Signaling Pathway NIK/NF-kappaB Signaling Fc-epsilon Receptor Signaling Pathway Negative Regulation Of Programmed Cell Death Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of MRNA Stability Post-translational Protein Modification Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of RNA Polymerase II Transcription Preinitiation Complex Assembly Modulation Of Chemical Synaptic Transmission T Cell Receptor Signaling Pathway Transmembrane Transport Wnt Signaling Pathway, Planar Cell Polarity Pathway Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Interleukin-1-mediated Signaling Pathway Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Inclusion Body Assembly Positive Regulation Of Canonical Wnt Signaling Pathway Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Hematopoietic Stem Cell Differentiation
Pathways		Viral RNP Complexes in the Host Cell Nucleus Regulation of HSF1-mediated heat shock response HSP90 chaperone cycle for steroid hormone receptors (SHR) Attenuation phase HSF1-dependent transactivation AUF1 (hnRNP D0) binds and destabilizes mRNA Neutrophil degranulation Regulation of HSF1-mediated heat shock response HSP90 chaperone cycle for steroid hormone receptors (SHR) Attenuation phase HSF1-dependent transactivation Neutrophil degranulation	Activation of NF-kappaB in B cells Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha ER-Phagosome pathway Cross-presentation of soluble exogenous antigens (endosomes) Autodegradation of Cdh1 by Cdh1:APC/C SCF-beta-TrCP mediated degradation of Emi1 APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Vpu mediated degradation of CD4 Vif-mediated degradation of APOBEC3G SCF(Skp2)-mediated degradation of p27/p21 Degradation of beta-catenin by the destruction complex Downstream TCR signaling Regulation of activated PAK-2p34 by proteasome mediated degradation Separation of Sister Chromatids FCERI mediated NF-kB activation Autodegradation of the E3 ubiquitin ligase COP1 Regulation of ornithine decarboxylase (ODC) ABC-family proteins mediated transport AUF1 (hnRNP D0) binds and destabilizes mRNA Asymmetric localization of PCP proteins Degradation of AXIN Degradation of DVL Hedgehog ligand biogenesis Hh mutants are degraded by ERAD Dectin-1 mediated noncanonical NF-kB signaling CLEC7A (Dectin-1) signaling Degradation of GLI1 by the proteasome Degradation of GLI2 by the proteasome GLI3 is processed to GLI3R by the proteasome Hedgehog 'on' state Regulation of RAS by GAPs TNFR2 non-canonical NF-kB pathway NIK-->noncanonical NF-kB signaling Defective CFTR causes cystic fibrosis MAPK6/MAPK4 signaling UCH proteinases Ub-specific processing proteases CDT1 association with the CDC6:ORC:origin complex Orc1 removal from chromatin CDK-mediated phosphorylation and removal of Cdc6 G2/M Checkpoints Ubiquitin Mediated Degradation of Phosphorylated Cdc25A Ubiquitin-dependent degradation of Cyclin D The role of GTSE1 in G2/M progression after G2 checkpoint FBXL7 down-regulates AURKA during mitotic entry and in early mitosis RUNX1 regulates transcription of genes involved in differentiation of HSCs Regulation of RUNX2 expression and activity Regulation of RUNX2 expression and activity Regulation of RUNX3 expression and activity Regulation of PTEN stability and activity Neddylation Regulation of expression of SLITs and ROBOs Interleukin-1 signaling Negative regulation of NOTCH4 signaling Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Asthma ( 31619474) Asthma (childhood onset) ( 31619474) Asthma and major depressive disorder ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 28240269) Inflammatory bowel disease ( 28067908) Schizophrenia ( 30285260) Ulcerative colitis ( 28067908)
Interacting Genes		88 interacting genes: AIFM1 AIMP2 APAF1 APEX1 APOB ATXN1 BAG1 BAG2 BAG3 BAG4 BCL2 BRSK1 CACNA1E CDK9 CFAP52 DAPP1 DNAAF4 DNAJA2 DNAJA3 DNAJB1 DNAJB11 DNAJC3 EGFR EIF2AK2 ERBB2 ERBB3 FANCC FOS GPR37 GRIN1 GRIN2D HAP1 HCFC1 HEMGN HIVEP1 HMGA1 HSBP1 HSF1 HSPA8 HSPBP1 IKBKG INS KRT18 KRT7 MAP3K5 MAPRE1 METTL21A MOS MSR1 NQO1 NR3C1 PEX5 PGR PLG POT1 PPP1R15A PRKCA PSMC5 PTGES3 PTMA PTPRF RAP1A RAPGEF2 RHOA SAE1 SLC13A1 SLC5A1 SNCB SNRK SOX9 ST13 STIP1 STUB1 SUMO2 TCERG1 TGM2 TOMM70 TP53 TRIAP1 TRIM24 TRIM38 TSSK6 TTC1 XIAP YWHAB YWHAG YWHAQ YWHAZ	80 interacting genes: AKT1 AZIN2 BACH2 BFSP2 CAMK2A CCDC136 CDC42 CFAP206 EPHA8 ERCC3 ERCC6 ESR1 ESR2 ESRRA ESRRG FOS GTF2B HARS1 HNF4G HOMER3 HSPA1A HTT INSIG2 KRT15 KRT27 KRT31 KRT38 KRT40 LAMB1 LAMC1 MDM2 MYO18B NR1H3 NR1I2 NR1I3 NR3C2 PDC PDCL PLEKHO1 PPARD PRKN PSMC1 PSMC2 PSMC3 PSMC4 PSMC6 PSMD11 PSMD12 RAD23A RARA RARB RARG RORA RORB RORC RXRA SCOC SHOC2 SIRPA SKA1 SP1 SSNA1 SUMO2 TAF10 TFIP11 THAP11 THRB TNNI2 TNNI3 TNNT1 TP53 TPM1 TPM3 TRIP11 UBC UBE3C UBLCP1 USP4 VDR VIM
Entrez ID		3303	5705
HPRD ID		00774	03400
Ensembl ID		ENSG00000204389	ENSG00000087191
Uniprot IDs		A8K5I0 B3KTT5 P0DMV8 P0DMV9	A0A140VJS3 P62195
PDB IDs		1HJO 1S3X 1XQS 2E88 2E8A 2LMG 3A8Y 3ATU 3ATV 3AY9 3D2E 3D2F 3JXU 3LOF 3Q49 4IO8 4J8F 4PO2 4WV5 4WV7 5AQW 5AQX 5AQY 5AQZ 5AR0 5BN8 5BN9 5BPL 5BPM 5BPN 5GJJ 5MKR 5MKS 5XI9 5XIR 6FDT 6FHK 6G3R 6G3S 6JPV 6K39	2KRK 3KW6 5GJQ 5GJR 5L4G 5LN3 5M32 5T0C 5T0G 5T0H 5T0I 5T0J 5VFP 5VFQ 5VFR 5VFS 5VFT 5VFU 5VGZ 5VHF 5VHH 5VHI 5VHJ 5VHM 5VHN 5VHO 5VHP 5VHQ 5VHR 5VHS 6MSB 6MSD 6MSG 6MSH 6MSJ 6MSK 6WJD 6WJN
Enriched GO Terms of Interacting Partners?
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