OSTM1 and RGS17

Data Source:
HPRD (two hybrid)

		OSTM1	RGS17
Description		osteoclastogenesis associated transmembrane protein 1	regulator of G protein signaling 17
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GO Annotations	Cellular Component	Lysosomal Membrane Cytosol Integral Component Of Membrane	Nucleus Cytoplasm Plasma Membrane Neuron Projection Synapse
	Molecular Function		GTPase Activity GTPase Activator Activity Protein Binding
	Biological Process	Osteoclast Differentiation Ion Transmembrane Transport	Response To Amphetamine G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Signal Transduction Positive Regulation Of GTPase Activity
Pathways		Stimuli-sensing channels	G alpha (q) signalling events G alpha (i) signalling events G alpha (z) signalling events G alpha (z) signalling events
Drugs
Diseases		Osteopetrosis, including: Osteopetrosis, severe neonatal or infantile forms; Osteopetrosis, intermediate forms; Osteopetrosis with renal tubular acidosis; Osteopetrosis, late-onset form type 1; Osteopetrosis, late-onset form type 2; Osteopetrosis, osteoclast poor
GWAS		Major depressive disorder ( 29187746)	Adult body size ( 32376654) Alcohol dependence ( 26365420) Apolipoprotein A1 levels ( 32203549) Bacterial meningitis ( 31092817) Body mass index ( 28892062) Cuneus cortex volume ( 31530798) Diastolic blood pressure ( 30224653) General risk tolerance (MTAG) ( 30643258) HDL cholesterol levels ( 32203549) High density lipoprotein cholesterol levels ( 29083408) Lipoprotein (a) levels ( 26377243) Morning person ( 30696823) Pneumococcal meningitis ( 31092817) Prostate cancer ( 23535732) Triglyceride levels ( 32203549)
Interacting Genes		6 interacting genes: CLCN7 GPSM1 LIG4 RGS17 RGS19 RGS20	43 interacting genes: ADRB2 AQP1 BOLA2 BOLA2B CHRD CRCT1 CREB5 DHX37 GNAI1 GNAI3 HOXA1 HSD3B7 KRTAP4-11 KRTAP5-11 KRTAP5-3 KRTAP5-4 KRTAP5-6 LCE1A LCE1B LCE1D LCE1E LCE2A LCE2B LCE2C LCE3A LCE3B LCE3C LCE3D LCE3E LCE4A LCE5A NUFIP2 OSTM1 OTX1 PTGER3 RABEP1 RBBP8 RPL10A SLC39A7 SMCP STUB1 TBC1D16 VASN
Entrez ID		28962	26575
HPRD ID		09628	06223
Ensembl ID		ENSG00000081087	ENSG00000091844
Uniprot IDs		Q86WC4	Q9UGC6
PDB IDs		7BXU 7JM7	1ZV4 6AM3
Enriched GO Terms of Interacting Partners?
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