OSTM1 and RGS20

Data Source:
HPRD (two hybrid)

		OSTM1	RGS20
Description		osteoclastogenesis associated transmembrane protein 1	regulator of G protein signaling 20
Image			No pdb structure
GO Annotations	Cellular Component	Lysosomal Membrane Cytosol Integral Component Of Membrane	Nucleus Cytoplasm Trans-Golgi Network Plasma Membrane
	Molecular Function		GTPase Activity GTPase Activator Activity Protein Binding
	Biological Process	Osteoclast Differentiation Ion Transmembrane Transport	G Protein-coupled Receptor Signaling Pathway Regulation Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Signal Transduction Positive Regulation Of GTPase Activity
Pathways		Stimuli-sensing channels	G alpha (i) signalling events G alpha (i) signalling events G alpha (z) signalling events G alpha (z) signalling events
Drugs
Diseases		Osteopetrosis, including: Osteopetrosis, severe neonatal or infantile forms; Osteopetrosis, intermediate forms; Osteopetrosis with renal tubular acidosis; Osteopetrosis, late-onset form type 1; Osteopetrosis, late-onset form type 2; Osteopetrosis, osteoclast poor
GWAS		Major depressive disorder ( 29187746)	Cerebrospinal fluid beta-site APP cleaving enzyme levels ( 29751835) Chronic obstructive pulmonary disease ( 32222710) Serum uric acid levels ( 29559957) Urinary albumin-to-creatinine ratio ( 26631737)
Interacting Genes		6 interacting genes: CLCN7 GPSM1 LIG4 RGS17 RGS19 RGS20	54 interacting genes: ABHD17A ADRB2 ALPP AQP1 CATSPER1 COL8A1 CRCT1 CREB5 FASLG GLRX3 GNAI1 GNAI2 GNAI3 GNAO1 GNAZ HOXA1 HRG HSPD1 INS KIF1A KLHL38 KRTAP4-2 KRTAP5-11 KRTAP5-6 KRTAP5-9 KRTAP9-3 KRTAP9-8 LCE1A LCE1B LCE1F LCE2A LCE2B LCE2C LCE2D LCE3A LCE3C LCE3D LCE3E LCE4A LCE5A LNX1 MAPKBP1 NECTIN2 NECTIN3 NEK8 NUFIP2 OSTM1 OTX1 PTGER3 PTPMT1 RANBP3 STMN2 TBC1D16 VASN
Entrez ID		28962	8601
HPRD ID		09628	06225
Ensembl ID		ENSG00000081087	ENSG00000147509
Uniprot IDs		Q86WC4	B3KSW4 H9NIM5 O76081
PDB IDs		7BXU 7JM7
Enriched GO Terms of Interacting Partners?
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