OSTM1 and GPSM1

Data Source:
BioGRID (pull down)

		OSTM1	GPSM1
Description		osteoclastogenesis associated transmembrane protein 1	G protein signaling modulator 1
Image			No pdb structure
GO Annotations	Cellular Component	Lysosomal Membrane Cytosol Integral Component Of Membrane	Golgi Membrane Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Cell Cortex Protein-containing Complex
	Molecular Function		GDP-dissociation Inhibitor Activity Protein Binding
	Biological Process	Osteoclast Differentiation Ion Transmembrane Transport	Nervous System Development Positive Regulation Of Macroautophagy Cell Differentiation Negative Regulation Of GTPase Activity Negative Regulation Of Guanyl-nucleotide Exchange Factor Activity
Pathways		Stimuli-sensing channels	G alpha (i) signalling events
Drugs
Diseases		Osteopetrosis, including: Osteopetrosis, severe neonatal or infantile forms; Osteopetrosis, intermediate forms; Osteopetrosis with renal tubular acidosis; Osteopetrosis, late-onset form type 1; Osteopetrosis, late-onset form type 2; Osteopetrosis, osteoclast poor
GWAS		Major depressive disorder ( 29187746)	Acute insulin response (insulin secretion adjusted) ( 28490609) Birth weight ( 31043758) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Insulinogenic index ( 23263489) Joint damage in rheumatoid arthritis ( 26498133) Offspring birth weight ( 31043758) Type 2 diabetes ( 30297969 29632382 26818947 23945395 31118516 32499647 30718926 28869590) Type 2 diabetes (adjusted for BMI) ( 29632382) Ulcerative colitis ( 28067908) White blood cell count ( 29403010)
Interacting Genes		6 interacting genes: CLCN7 GPSM1 LIG4 RGS17 RGS19 RGS20	26 interacting genes: BHLHE40 CCDC158 DAZAP2 DCAF11 DMRT3 FAM161B FAM83A FAM90A1 GCM2 GLIS2 GNAI1 GNAI3 HMG20A INSC KANK2 MAP1LC3A OSTM1 RIBC1 SEPTIN1 TASOR2 TEKT4 TRIP13 USHBP1 USP9X VEZF1 ZBED1
Entrez ID		28962	26086
HPRD ID		09628	17075
Ensembl ID		ENSG00000081087	ENSG00000160360
Uniprot IDs		Q86WC4	A0A087WVF5 A0A0A0MRC4 A0A0A0MSK4 Q86YR5
PDB IDs		7BXU 7JM7
Enriched GO Terms of Interacting Partners?
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