OSTM1 and CLCN7

Data Source:
HPRD (in vivo)

		OSTM1	CLCN7
Description		osteoclastogenesis associated transmembrane protein 1	chloride voltage-gated channel 7
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GO Annotations	Cellular Component	Lysosomal Membrane Cytosol Integral Component Of Membrane	Nucleoplasm Lysosomal Membrane Membrane Integral Component Of Membrane Intracellular Membrane-bounded Organelle
	Molecular Function		Voltage-gated Chloride Channel Activity Chloride Channel Activity Protein Binding ATP Binding Chloride Transmembrane Transporter Activity Antiporter Activity
	Biological Process	Osteoclast Differentiation Ion Transmembrane Transport	Ion Transmembrane Transport Chloride Transmembrane Transport
Pathways		Stimuli-sensing channels	Stimuli-sensing channels
Drugs
Diseases		Osteopetrosis, including: Osteopetrosis, severe neonatal or infantile forms; Osteopetrosis, intermediate forms; Osteopetrosis with renal tubular acidosis; Osteopetrosis, late-onset form type 1; Osteopetrosis, late-onset form type 2; Osteopetrosis, osteoclast poor	Osteopetrosis, including: Osteopetrosis, severe neonatal or infantile forms; Osteopetrosis, intermediate forms; Osteopetrosis with renal tubular acidosis; Osteopetrosis, late-onset form type 1; Osteopetrosis, late-onset form type 2; Osteopetrosis, osteoclast poor
GWAS		Major depressive disorder ( 29187746)	Acute anterior uveitis in ankylosing spondylitis ( 32492107) Refractive error ( 32231278)
Interacting Genes		6 interacting genes: CLCN7 GPSM1 LIG4 RGS17 RGS19 RGS20	17 interacting genes: AQP7 CD53 CREB3 GDAP1 GET1 KCNN3 LHFPL5 LMNA LYVE1 MTDH OPRM1 OSTM1 PACS1 SLC38A7 SLC66A2 TLCD4 TMEM179B
Entrez ID		28962	1186
HPRD ID		09628	04103
Ensembl ID		ENSG00000081087	ENSG00000103249
Uniprot IDs		Q86WC4	P51798
PDB IDs		7BXU 7JM7	7BXU 7JM7
Enriched GO Terms of Interacting Partners?
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