OSTM1 and RGS19

Data Source:
HPRD (two hybrid, in vitro)

		OSTM1	RGS19
Description		osteoclastogenesis associated transmembrane protein 1	regulator of G protein signaling 19
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GO Annotations	Cellular Component	Lysosomal Membrane Cytosol Integral Component Of Membrane	Golgi Apparatus Plasma Membrane Brush Border Membrane Clathrin-coated Vesicle Membrane Raft
	Molecular Function		G-protein Alpha-subunit Binding GTPase Activity Protein Binding
	Biological Process	Osteoclast Differentiation Ion Transmembrane Transport	Autophagy G Protein-coupled Receptor Signaling Pathway Small GTPase Mediated Signal Transduction Negative Regulation Of Signal Transduction Response To Ethanol
Pathways		Stimuli-sensing channels	G alpha (q) signalling events G alpha (i) signalling events G alpha (i) signalling events G alpha (z) signalling events
Drugs
Diseases		Osteopetrosis, including: Osteopetrosis, severe neonatal or infantile forms; Osteopetrosis, intermediate forms; Osteopetrosis with renal tubular acidosis; Osteopetrosis, late-onset form type 1; Osteopetrosis, late-onset form type 2; Osteopetrosis, osteoclast poor
GWAS		Major depressive disorder ( 29187746)	Cerebrospinal AB1-42 levels in normal cognition ( 29274321) Chronic kidney disease ( 31152163) Coronary artery disease ( 33020668) Estimated glomerular filtration rate ( 31152163) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494 27863252) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Systolic blood pressure ( 30578418)
Interacting Genes		6 interacting genes: CLCN7 GPSM1 LIG4 RGS17 RGS19 RGS20	25 interacting genes: ALPP CATSPER1 CSNK2A1 CSNK2A2 GDE1 GIPC1 GNAI1 GNAI2 GNAI3 GNAO1 GNAZ HOXA1 KRTAP5-6 LCE4A MAPK1 MAPK6 NUFIP2 OPRL1 OSTM1 OTX1 POU4F2 PRKCA PSMA1 TGFBR1 VASN
Entrez ID		28962	10287
HPRD ID		09628	05461
Ensembl ID		ENSG00000081087	ENSG00000171700
Uniprot IDs		Q86WC4	B4DP94 P49795
PDB IDs		7BXU 7JM7	1CMZ
Enriched GO Terms of Interacting Partners?
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