GPX1 and MAPK6

Data Source:
BioGRID (two hybrid)

		GPX1	MAPK6
Description		glutathione peroxidase 1	mitogen-activated protein kinase 6
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GO Annotations	Cellular Component	Cytoplasm Mitochondrion Mitochondrial Matrix Cytosol Lewy Body	Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Peroxidase Activity Glutathione Peroxidase Activity SH3 Domain Binding Phospholipid-hydroperoxide Glutathione Peroxidase Activity	Protein Serine/threonine Kinase Activity MAP Kinase Activity Protein Binding ATP Binding
	Biological Process	Temperature Homeostasis Endothelial Cell Development Negative Regulation Of Inflammatory Response To Antigenic Stimulus Purine Nucleotide Catabolic Process Triglyceride Metabolic Process Glutathione Metabolic Process Sensory Perception Of Sound Response To Xenobiotic Stimulus Response To Symbiotic Bacterium UV Protection Response To Selenium Ion Response To Gamma Radiation Protein Oxidation Arachidonic Acid Metabolic Process Lipoxygenase Pathway Response To Hydroperoxide Regulation Of Mammary Gland Epithelial Cell Proliferation Cellular Response To Oxidative Stress Regulation Of Gene Expression, Epigenetic Vasodilation Response To Hydrogen Peroxide Hydrogen Peroxide Catabolic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Skeletal Muscle Tissue Regeneration Blood Vessel Endothelial Cell Migration Fat Cell Differentiation Cell Redox Homeostasis Skeletal Muscle Fiber Development Myoblast Proliferation Biological Process Involved In Interaction With Symbiont Positive Regulation Of Protein Kinase B Signaling Heart Contraction Angiogenesis Involved In Wound Healing Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Release Of Cytochrome C From Mitochondria Cellular Oxidant Detoxification Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Supramolecular Fiber Organization	MAPK Cascade Protein Phosphorylation Cell Cycle Signal Transduction Intracellular Signal Transduction
Pathways		Synthesis of 5-eicosatetraenoic acids Synthesis of 12-eicosatetraenoic acid derivatives Synthesis of 15-eicosatetraenoic acid derivatives Detoxification of Reactive Oxygen Species Purine catabolism	MAPK6/MAPK4 signaling
Drugs		Glutathione Glutathione Glutathione disulfide Cannabidiol Medical Cannabis Nabiximols	Acetylsalicylic acid Minocycline
Diseases		Anemia due to disorders of glutathione metabolism, including: Glucose-6-phosphate dehydrogenase (G6PD) deficiency; Glutathione peroxidase (GPX) deficiency; Gamma-glutamylcysteine synthetase (GCLC) deficiency; Glutathione synthetase (GSS) deficiency
GWAS		Blood protein levels ( 28240269) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908 21102463) Extremely high intelligence ( 29520040) Hemoglobin levels ( 32327693) Household income (MTAG) ( 31844048) Inflammatory bowel disease ( 28067908 23128233) Intelligence (MTAG) ( 29326435) Mood instability ( 31168069) Sleep duration (short sleep) ( 30846698) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Ulcerative colitis ( 28067908 25082827)	Serum uric acid levels in response to allopurinol in gout ( 25676789)
Interacting Genes		5 interacting genes: ABL1 ABL2 FAM9B MAPK6 SELENBP1	166 interacting genes: ACTG1 ACTR1B AMPH ANAPC5 ANK3 ANKRD2 APBA2 ARHGDIA ARPC3 ATG9A ATP5PF BAG6 BARX1 BBS10 CA1 CA12 CALR CASP6 CCND3 CCT3 CDH13 CERS1 CFAP298 CFL1 CNTN1 CNTRL COPS6 CSE1L CYRIB CYTH2 DBN1 DCTN2 DDOST DDR1 DGKZ DKC1 DNAJC28 DPPA4 DST DYNC2I2 EDF1 EEF1A2 EIF1 EIF3C EIF4A1 ELOF1 EMD FBXL16 FOXO3 FXYD3 GALNT7 GATA1 GLRX3 GORASP1 GPX1 HACL1 HAUS2 HDAC11 HIP1 HNRNPA0 HNRNPD HNRNPH3 HSP90AB1 HSP90B1 HSPD1 IDH3B INS ITGB3BP ITSN1 JUNB KDSR KLC1 KNSTRN LPXN MAP3K12 MAP3K7 MAPKAPK5 MASP1 MBIP MBOAT7 MCM3 MDK METTL17 METTL2A MGAT1 MIPEP MOK MON1A MTG2 MYBL2 MYOZ3 MZB1 NAT9 NAXE NDUFS6 NECTIN2 NELFB NOL4 NRXN2 NUDT5 OSTF1 PDCD6IP PDLIM1 PHACTR3 PHC2 PHGDH PIH1D1 PLEKHM1 PLSCR1 PPBP PPP1R7 PPP2R1A PRKAB1 PRKAR1A PRKCB PRPF38A PSAT1 PSIP1 PTPMT1 RAB2A RAB31 RACK1 RANBP9 RAP1GAP RARA RBL1 RGS19 RPL10 RRP7A SEPTIN3 SEPTIN5 SERPINA4 SHC1 SLC20A1 SLC41A3 SMAD6 SMS SNAPC4 SNW1 SOCS3 SPG7 SPRR2D SPTAN1 SRSF5 STX7 TDP2 THAP4 TPI1 TTK TUBA1A UBA52 UBE2L3 URB1 USP20 VPS26C WDR26 WFS1 WWC1 XPO1 ZNF133 ZNF205 ZNF331 ZNF579 ZNF600 ZNF671 ZNF775
Entrez ID		2876	5597
HPRD ID		11749	04213
Ensembl ID		ENSG00000233276	ENSG00000069956
Uniprot IDs		A0A2R8Y6B6 P07203 Q7L4Q3	Q16659
PDB IDs		2F8A	6YKY 6YLC 6YLL 7AQB
Enriched GO Terms of Interacting Partners?
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