GPX1 and ABL2

Data Source:
BioGRID (affinity chromatography technology, pull down, enzymatic study)
HPRD (in vitro)

		GPX1	ABL2
Description		glutathione peroxidase 1	ABL proto-oncogene 2, non-receptor tyrosine kinase
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GO Annotations	Cellular Component	Cytoplasm Mitochondrion Mitochondrial Matrix Cytosol Lewy Body	Cytosol Actin Cytoskeleton
	Molecular Function	Peroxidase Activity Glutathione Peroxidase Activity SH3 Domain Binding Phospholipid-hydroperoxide Glutathione Peroxidase Activity	Magnesium Ion Binding Phosphotyrosine Residue Binding Actin Monomer Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Binding ATP Binding Manganese Ion Binding Actin Filament Binding
	Biological Process	Temperature Homeostasis Endothelial Cell Development Negative Regulation Of Inflammatory Response To Antigenic Stimulus Purine Nucleotide Catabolic Process Triglyceride Metabolic Process Glutathione Metabolic Process Sensory Perception Of Sound Response To Xenobiotic Stimulus Response To Symbiotic Bacterium UV Protection Response To Selenium Ion Response To Gamma Radiation Protein Oxidation Arachidonic Acid Metabolic Process Lipoxygenase Pathway Response To Hydroperoxide Regulation Of Mammary Gland Epithelial Cell Proliferation Cellular Response To Oxidative Stress Regulation Of Gene Expression, Epigenetic Vasodilation Response To Hydrogen Peroxide Hydrogen Peroxide Catabolic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Skeletal Muscle Tissue Regeneration Blood Vessel Endothelial Cell Migration Fat Cell Differentiation Cell Redox Homeostasis Skeletal Muscle Fiber Development Myoblast Proliferation Biological Process Involved In Interaction With Symbiont Positive Regulation Of Protein Kinase B Signaling Heart Contraction Angiogenesis Involved In Wound Healing Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Release Of Cytochrome C From Mitochondria Cellular Oxidant Detoxification Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Supramolecular Fiber Organization	Cellular Protein Modification Process Cell Adhesion Signal Transduction Positive Regulation Of Cytosolic Calcium Ion Concentration Regulation Of Autophagy Positive Regulation Of Phospholipase C Activity Positive Regulation Of Neuron Projection Development Peptidyl-tyrosine Phosphorylation Regulation Of Endocytosis Regulation Of Cell Adhesion Negative Regulation Of Rho Protein Signal Transduction Exploration Behavior Positive Regulation Of Oxidoreductase Activity Cellular Response To Retinoic Acid Regulation Of Cell Motility Regulation Of Actin Cytoskeleton Reorganization
Pathways		Synthesis of 5-eicosatetraenoic acids Synthesis of 12-eicosatetraenoic acid derivatives Synthesis of 15-eicosatetraenoic acid derivatives Detoxification of Reactive Oxygen Species Purine catabolism	Role of ABL in ROBO-SLIT signaling Role of ABL in ROBO-SLIT signaling Negative regulation of FLT3
Drugs		Glutathione Glutathione Glutathione disulfide Cannabidiol Medical Cannabis Nabiximols	ATP Dasatinib XL228 K-00546 Fostamatinib
Diseases		Anemia due to disorders of glutathione metabolism, including: Glucose-6-phosphate dehydrogenase (G6PD) deficiency; Glutathione peroxidase (GPX) deficiency; Gamma-glutamylcysteine synthetase (GCLC) deficiency; Glutathione synthetase (GSS) deficiency
GWAS		Blood protein levels ( 28240269) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908 21102463) Extremely high intelligence ( 29520040) Hemoglobin levels ( 32327693) Household income (MTAG) ( 31844048) Inflammatory bowel disease ( 28067908 23128233) Intelligence (MTAG) ( 29326435) Mood instability ( 31168069) Sleep duration (short sleep) ( 30846698) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Ulcerative colitis ( 28067908 25082827)	IgE grass sensitization ( 22036096)
Interacting Genes		5 interacting genes: ABL1 ABL2 FAM9B MAPK6 SELENBP1	34 interacting genes: ABI2 ABL1 AR BCR C15orf48 CAT CRK DOK1 EGFR EPHB2 ERBB2 ERBB3 ERBB4 FBXO38 GPX1 GRB2 HCK KIT MAP3K10 MDM2 MET NEDD4 NEDD4L OIP5 PDGFRB PIK3R3 PSMA7 RIN1 SIVA1 SORBS2 STAT3 TPD52L1 TRIP10 ZMAT1
Entrez ID		2876	27
HPRD ID		11749	01259
Ensembl ID		ENSG00000233276	ENSG00000143322
Uniprot IDs		A0A2R8Y6B6 P07203 Q7L4Q3	P42684
PDB IDs		2F8A	2ECD 2KK1 2XYN 3GVU 3HMI 3ULR 4EIH 5NP3 5NP5
Enriched GO Terms of Interacting Partners?
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