MAPK6 and CA12

Data Source:
BioGRID (two hybrid)

		MAPK6	CA12
Description		mitogen-activated protein kinase 6	carbonic anhydrase 12
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol	Plasma Membrane Integral Component Of Membrane
	Molecular Function	Protein Serine/threonine Kinase Activity MAP Kinase Activity Protein Binding ATP Binding	Carbonate Dehydratase Activity Zinc Ion Binding Hydro-lyase Activity
	Biological Process	MAPK Cascade Protein Phosphorylation Cell Cycle Signal Transduction Intracellular Signal Transduction	One-carbon Metabolic Process Bicarbonate Transport Chloride Ion Homeostasis
Pathways		MAPK6/MAPK4 signaling	Reversible hydration of carbon dioxide
Drugs		Acetylsalicylic acid Minocycline	Benzthiazide Hydroflumethiazide Acetazolamide Zonisamide Ellagic acid
Diseases
GWAS		Serum uric acid levels in response to allopurinol in gout ( 25676789)	Dentures ( 31235808) Number of decayed, missing and filled tooth surfaces ( 31235808) Number of decayed, missing and filled tooth surfaces or use of dentures ( 31235808) Refractive error ( 32231278)
Interacting Genes		166 interacting genes: ACTG1 ACTR1B AMPH ANAPC5 ANK3 ANKRD2 APBA2 ARHGDIA ARPC3 ATG9A ATP5PF BAG6 BARX1 BBS10 CA1 CA12 CALR CASP6 CCND3 CCT3 CDH13 CERS1 CFAP298 CFL1 CNTN1 CNTRL COPS6 CSE1L CYRIB CYTH2 DBN1 DCTN2 DDOST DDR1 DGKZ DKC1 DNAJC28 DPPA4 DST DYNC2I2 EDF1 EEF1A2 EIF1 EIF3C EIF4A1 ELOF1 EMD FBXL16 FOXO3 FXYD3 GALNT7 GATA1 GLRX3 GORASP1 GPX1 HACL1 HAUS2 HDAC11 HIP1 HNRNPA0 HNRNPD HNRNPH3 HSP90AB1 HSP90B1 HSPD1 IDH3B INS ITGB3BP ITSN1 JUNB KDSR KLC1 KNSTRN LPXN MAP3K12 MAP3K7 MAPKAPK5 MASP1 MBIP MBOAT7 MCM3 MDK METTL17 METTL2A MGAT1 MIPEP MOK MON1A MTG2 MYBL2 MYOZ3 MZB1 NAT9 NAXE NDUFS6 NECTIN2 NELFB NOL4 NRXN2 NUDT5 OSTF1 PDCD6IP PDLIM1 PHACTR3 PHC2 PHGDH PIH1D1 PLEKHM1 PLSCR1 PPBP PPP1R7 PPP2R1A PRKAB1 PRKAR1A PRKCB PRPF38A PSAT1 PSIP1 PTPMT1 RAB2A RAB31 RACK1 RANBP9 RAP1GAP RARA RBL1 RGS19 RPL10 RRP7A SEPTIN3 SEPTIN5 SERPINA4 SHC1 SLC20A1 SLC41A3 SMAD6 SMS SNAPC4 SNW1 SOCS3 SPG7 SPRR2D SPTAN1 SRSF5 STX7 TDP2 THAP4 TPI1 TTK TUBA1A UBA52 UBE2L3 URB1 USP20 VPS26C WDR26 WFS1 WWC1 XPO1 ZNF133 ZNF205 ZNF331 ZNF579 ZNF600 ZNF671 ZNF775	10 interacting genes: ATP5F1C CUX1 DAXX KATNBL1 LGALS7 MAPK6 MRPL9 RDH11 SGSM2 TOE1
Entrez ID		5597	771
HPRD ID		04213	04464
Ensembl ID		ENSG00000069956	ENSG00000074410
Uniprot IDs		Q16659	B3KUB4 O43570
PDB IDs		6YKY 6YLC 6YLL 7AQB	1JCZ 1JD0 4HT2 4KP5 4KP8 4Q0L 4QJ0 4QJO 4QJW 4WW8 5LL5 5LL9 5LLO 5LLP 5MSA 5MSB 6G5L 6G7A 6QN0 6QNG 6QNL 6R6Y 6R71 6RPS 6T5P 6T5Q
Enriched GO Terms of Interacting Partners?
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