GPR35 and SLC8A2

Data Source:
BioGRID (two hybrid)

		GPR35	SLC8A2
Description		G protein-coupled receptor 35	solute carrier family 8 member A2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane	Plasma Membrane Integral Component Of Plasma Membrane Postsynaptic Density Membrane Basolateral Plasma Membrane Axon Dendrite Sarcolemma Neuronal Cell Body Dendritic Spine Perikaryon Axon Terminus Synapse Presynapse Postsynapse
	Molecular Function	G Protein-coupled Receptor Activity C-X-C Chemokine Receptor Activity	Calcium:sodium Antiporter Activity Calmodulin Binding Sodium Ion Transmembrane Transporter Activity Calcium Ion Transmembrane Transporter Activity Cation:cation Antiporter Activity Metal Ion Binding Calcium:cation Antiporter Activity Involved In Regulation Of Postsynaptic Cytosolic Calcium Ion Concentration
	Biological Process	Cytoskeleton Organization G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Positive Regulation Of Rho Protein Signal Transduction Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G Protein-coupled Signaling Pathway Chemokine-mediated Signaling Pathway Negative Regulation Of Voltage-gated Calcium Channel Activity Negative Regulation Of Neuronal Action Potential	Response To Ischemia Ion Transport Cellular Calcium Ion Homeostasis Cell Communication Learning Or Memory Learning Memory Regulation Of Gene Expression Metal Ion Transport Sodium Ion Transmembrane Transport Regulation Of Short-term Neuronal Synaptic Plasticity Synapse Organization Cognition Regulation Of Cytosolic Calcium Ion Concentration Long-term Synaptic Potentiation Neuron Cellular Homeostasis Calcium Ion Transmembrane Transport Positive Regulation Of Protein Serine/threonine Kinase Activity Calcium Ion Import Across Plasma Membrane Modulation Of Excitatory Postsynaptic Potential Regulation Of Postsynaptic Cytosolic Calcium Ion Concentration Regulation Of Action Potential Firing Pattern Regulation Of Calcineurin-mediated Signaling Transport Across Blood-brain Barrier Regulation Of Cardiac Conduction Calcium Ion Export Across Plasma Membrane
Pathways		Class A/1 (Rhodopsin-like receptors)	Reduction of cytosolic Ca++ levels Sodium/Calcium exchangers Ion homeostasis
Drugs		Furosemide Pyrantel Kynurenic Acid
Diseases
GWAS		Ankylosing spondylitis ( 23749187) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 25489960) Granulocyte percentage of myeloid white cells ( 27863252) Inflammatory bowel disease ( 28067908 23128233) Monocyte count ( 27863252) Monocyte percentage of white cells ( 32888494 27863252) Pediatric autoimmune diseases ( 26301688) Sclerosing cholangitis and ulcerative colitis (combined) ( 22821403) Ulcerative colitis ( 28067908 21297633)	Resting-state electroencephalogram vigilance ( 29703947)
Interacting Genes		59 interacting genes: ABHD14A ADGRB1 AIG1 APH1A ATP1A1 ATP2C1 AUP1 B3GAT3 B4GALT2 BNIP1 CANX CD81 CH25H CMTM3 CRHR2 ERGIC3 FLRT1 FTH1 GHITM GJC2 GPR146 GPR161 HLA-A KCNJ4 KDELR1 LSS MCOLN1 MSMO1 NPC1 NSDHL OSTC PLD3 PLLP PLXDC1 PPP1R3F RTN3 RTN4 SCARB1 SDHD SELENOK SLC15A4 SLC2A1 SLC31A2 SLC37A1 SLC37A4 SLC45A4 SLC8A2 SLC9A7 SPART SYNGR2 SYT11 TMEM161A TMEM94 TSPAN7 VPS25 VTI1B YIF1B ZDHHC3 ZFAND1	7 interacting genes: GPR35 GPR37 PPP3CB YWHAB YWHAE YWHAQ YWHAZ
Entrez ID		2859	6543
HPRD ID		16003	15990
Ensembl ID		ENSG00000178623	ENSG00000118160
Uniprot IDs		A8K2J1 B2RA17 Q9HC97	Q9UPR5
PDB IDs
Enriched GO Terms of Interacting Partners?
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