GPR35 and NSDHL

Data Source:
BioGRID (two hybrid)

		GPR35	NSDHL
Description		G protein-coupled receptor 35	NAD(P) dependent steroid dehydrogenase-like
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Lipid Droplet Integral Component Of Membrane
	Molecular Function	G Protein-coupled Receptor Activity C-X-C Chemokine Receptor Activity	C-3 Sterol Dehydrogenase (C-4 Sterol Decarboxylase) Activity 3-beta-hydroxy-delta5-steroid Dehydrogenase Activity Protein Binding Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor Sterol-4-alpha-carboxylate 3-dehydrogenase (decarboxylating) Activity 4alpha-carboxy-4beta-methyl-5alpha-cholesta-8-en-3beta-ol:NAD(P)+ 3-oxidoreductase (decarboxylating) Activity 4alpha-carboxy-5alpha-cholesta-8-en-3beta-ol:NAD(P)+ 3-dehydrogenase (decarboxylating) Activity
	Biological Process	Cytoskeleton Organization G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Positive Regulation Of Rho Protein Signal Transduction Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G Protein-coupled Signaling Pathway Chemokine-mediated Signaling Pathway Negative Regulation Of Voltage-gated Calcium Channel Activity Negative Regulation Of Neuronal Action Potential	Hair Follicle Development Cholesterol Biosynthetic Process Smoothened Signaling Pathway Cholesterol Metabolic Process Labyrinthine Layer Blood Vessel Development
Pathways		Class A/1 (Rhodopsin-like receptors)	Cholesterol biosynthesis
Drugs		Furosemide Pyrantel Kynurenic Acid	NADH
Diseases			Syndromic X-linked mental retardation with epilepsy or seizures, including: West syndrome (WS); Partington syndrome (PRTS); Proud syndrome (ACCAG); XMR and epilepsy (XMRE); MRXHF1; XMR OPHN1-related (MRXSO) ; XELBD; XMR, Christianson type (MRXSC); Creatine deficiency syndrome (XL-CDS); Renpenning syndrome (RENS1); Epilepsy and mental retardation limited to females (EFMR); Periventricular nodular heterotopia (PVNH); Hydrocephalus (XLH); XMR, JARID1C related (MRXSJ); Boerjeson-Forssman syndrome (BFLS); CK syndrome (CKS) Congenital hemidysplasia with ichthyosiform nevus and limb defects (CHILD)
GWAS		Ankylosing spondylitis ( 23749187) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 25489960) Granulocyte percentage of myeloid white cells ( 27863252) Inflammatory bowel disease ( 28067908 23128233) Monocyte count ( 27863252) Monocyte percentage of white cells ( 32888494 27863252) Pediatric autoimmune diseases ( 26301688) Sclerosing cholangitis and ulcerative colitis (combined) ( 22821403) Ulcerative colitis ( 28067908 21297633)
Interacting Genes		59 interacting genes: ABHD14A ADGRB1 AIG1 APH1A ATP1A1 ATP2C1 AUP1 B3GAT3 B4GALT2 BNIP1 CANX CD81 CH25H CMTM3 CRHR2 ERGIC3 FLRT1 FTH1 GHITM GJC2 GPR146 GPR161 HLA-A KCNJ4 KDELR1 LSS MCOLN1 MSMO1 NPC1 NSDHL OSTC PLD3 PLLP PLXDC1 PPP1R3F RTN3 RTN4 SCARB1 SDHD SELENOK SLC15A4 SLC2A1 SLC31A2 SLC37A1 SLC37A4 SLC45A4 SLC8A2 SLC9A7 SPART SYNGR2 SYT11 TMEM161A TMEM94 TSPAN7 VPS25 VTI1B YIF1B ZDHHC3 ZFAND1	4 interacting genes: GPR35 RHBDD1 TMEM31 TMX2
Entrez ID		2859	50814
HPRD ID		16003	02229
Ensembl ID		ENSG00000178623	ENSG00000147383
Uniprot IDs		A8K2J1 B2RA17 Q9HC97	A0A384NPZ7 Q15738
PDB IDs			6JKG 6JKH
Enriched GO Terms of Interacting Partners?
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