GPR35 and ATP2C1

Data Source:
BioGRID (two hybrid)

		GPR35	ATP2C1
Description		G protein-coupled receptor 35	ATPase secretory pathway Ca2+ transporting 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane	Golgi Membrane Endoplasmic Reticulum Golgi Apparatus Trans-Golgi Network Plasma Membrane Membrane Integral Component Of Membrane
	Molecular Function	G Protein-coupled Receptor Activity C-X-C Chemokine Receptor Activity	Calcium Transmembrane Transporter Activity, Phosphorylative Mechanism ATP Binding Proton-exporting ATPase Activity, Phosphorylative Mechanism Manganese Transmembrane Transporter Activity, Phosphorylative Mechanism ATPase Activity Metal Ion Binding
	Biological Process	Cytoskeleton Organization G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Positive Regulation Of Rho Protein Signal Transduction Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G Protein-coupled Signaling Pathway Chemokine-mediated Signaling Pathway Negative Regulation Of Voltage-gated Calcium Channel Activity Negative Regulation Of Neuronal Action Potential	Calcium Ion Transport Manganese Ion Transport Cellular Calcium Ion Homeostasis Epidermis Development Calcium-dependent Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Actin Cytoskeleton Reorganization Golgi Calcium Ion Homeostasis Golgi Calcium Ion Transport Ion Transmembrane Transport Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Calcium Ion Transmembrane Transport Manganese Ion Transmembrane Transport Proton Transmembrane Transport
Pathways		Class A/1 (Rhodopsin-like receptors)	Ion transport by P-type ATPases
Drugs		Furosemide Pyrantel Kynurenic Acid	Enflurane Isoflurane Methoxyflurane Desflurane Sevoflurane Calcium
Diseases			Hailey-Hailey disease; Benign familial pemphigus
GWAS		Ankylosing spondylitis ( 23749187) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 25489960) Granulocyte percentage of myeloid white cells ( 27863252) Inflammatory bowel disease ( 28067908 23128233) Monocyte count ( 27863252) Monocyte percentage of white cells ( 32888494 27863252) Pediatric autoimmune diseases ( 26301688) Sclerosing cholangitis and ulcerative colitis (combined) ( 22821403) Ulcerative colitis ( 28067908 21297633)	Refractive error ( 32231278) Restless legs syndrome ( 29029846) Waist circumference ( 28552196)
Interacting Genes		59 interacting genes: ABHD14A ADGRB1 AIG1 APH1A ATP1A1 ATP2C1 AUP1 B3GAT3 B4GALT2 BNIP1 CANX CD81 CH25H CMTM3 CRHR2 ERGIC3 FLRT1 FTH1 GHITM GJC2 GPR146 GPR161 HLA-A KCNJ4 KDELR1 LSS MCOLN1 MSMO1 NPC1 NSDHL OSTC PLD3 PLLP PLXDC1 PPP1R3F RTN3 RTN4 SCARB1 SDHD SELENOK SLC15A4 SLC2A1 SLC31A2 SLC37A1 SLC37A4 SLC45A4 SLC8A2 SLC9A7 SPART SYNGR2 SYT11 TMEM161A TMEM94 TSPAN7 VPS25 VTI1B YIF1B ZDHHC3 ZFAND1	3 interacting genes: F2RL1 GPR35 GTF2IRD1
Entrez ID		2859	27032
HPRD ID		16003	05089
Ensembl ID		ENSG00000178623	ENSG00000017260
Uniprot IDs		A8K2J1 B2RA17 Q9HC97	B4E295 B4E2Q0 P98194
PDB IDs
Enriched GO Terms of Interacting Partners?
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