GPR35 and SLC15A4

Data Source:
BioGRID (two hybrid)

		GPR35	SLC15A4
Description		G protein-coupled receptor 35	solute carrier family 15 member 4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane	Lysosomal Membrane Plasma Membrane Integral Component Of Endosome Membrane Early Endosome Membrane Specific Granule Membrane Endolysosome Membrane Integral Component Of Lysosomal Membrane
	Molecular Function	G Protein-coupled Receptor Activity C-X-C Chemokine Receptor Activity	L-histidine Transmembrane Transporter Activity Protein Binding Peptide:proton Symporter Activity Peptidoglycan Transmembrane Transporter Activity Dipeptide Transmembrane Transporter Activity
	Biological Process	Cytoskeleton Organization G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Positive Regulation Of Rho Protein Signal Transduction Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G Protein-coupled Signaling Pathway Chemokine-mediated Signaling Pathway Negative Regulation Of Voltage-gated Calcium Channel Activity Negative Regulation Of Neuronal Action Potential	Ion Transport Protein Transport Histidine Transport Peptidoglycan Transport Mast Cell Homeostasis Positive Regulation Of Toll-like Receptor 7 Signaling Pathway Positive Regulation Of Toll-like Receptor 8 Signaling Pathway Positive Regulation Of Toll-like Receptor 9 Signaling Pathway Neutrophil Degranulation Innate Immune Response Positive Regulation Of Innate Immune Response Regulation Of Isotype Switching To IgG Isotypes Regulation Of Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Positive Regulation Of Nucleotide-binding Oligomerization Domain Containing 1 Signaling Pathway Positive Regulation Of Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway L-histidine Transmembrane Export From Vacuole Dipeptide Import Across Plasma Membrane Proton Transmembrane Transport
Pathways		Class A/1 (Rhodopsin-like receptors)	Proton/oligopeptide cotransporters Neutrophil degranulation
Drugs		Furosemide Pyrantel Kynurenic Acid
Diseases
GWAS		Ankylosing spondylitis ( 23749187) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 25489960) Granulocyte percentage of myeloid white cells ( 27863252) Inflammatory bowel disease ( 28067908 23128233) Monocyte count ( 27863252) Monocyte percentage of white cells ( 32888494 27863252) Pediatric autoimmune diseases ( 26301688) Sclerosing cholangitis and ulcerative colitis (combined) ( 22821403) Ulcerative colitis ( 28067908 21297633)	Basophil count ( 32888494) Basophil percentage of white cells ( 32888494) Cognitive decline rate in late mild cognitive impairment ( 26252872) Palmitic acid (16:0) levels ( 23362303) Periodontal disease related phenotype (PCT5) ( 26962152) Systemic lupus erythematosus ( 27399966 23273568 26663301 26502338 28714469 19838193 19838195)
Interacting Genes		59 interacting genes: ABHD14A ADGRB1 AIG1 APH1A ATP1A1 ATP2C1 AUP1 B3GAT3 B4GALT2 BNIP1 CANX CD81 CH25H CMTM3 CRHR2 ERGIC3 FLRT1 FTH1 GHITM GJC2 GPR146 GPR161 HLA-A KCNJ4 KDELR1 LSS MCOLN1 MSMO1 NPC1 NSDHL OSTC PLD3 PLLP PLXDC1 PPP1R3F RTN3 RTN4 SCARB1 SDHD SELENOK SLC15A4 SLC2A1 SLC31A2 SLC37A1 SLC37A4 SLC45A4 SLC8A2 SLC9A7 SPART SYNGR2 SYT11 TMEM161A TMEM94 TSPAN7 VPS25 VTI1B YIF1B ZDHHC3 ZFAND1	3 interacting genes: DRD2 GLP1R GPR35
Entrez ID		2859	121260
HPRD ID		16003	11566
Ensembl ID		ENSG00000178623	ENSG00000139370
Uniprot IDs		A8K2J1 B2RA17 Q9HC97	Q8N697
PDB IDs
Enriched GO Terms of Interacting Partners?
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