SLC15A4 and GLP1R

Data Source:
BioGRID (protein complementation assay, protein complementation assay, affinity chromatography technology)

		SLC15A4	GLP1R
Description		solute carrier family 15 member 4	glucagon like peptide 1 receptor
Image		No pdb structure
GO Annotations	Cellular Component	Lysosomal Membrane Plasma Membrane Integral Component Of Endosome Membrane Early Endosome Membrane Specific Granule Membrane Endolysosome Membrane Integral Component Of Lysosomal Membrane	Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Membrane
	Molecular Function	L-histidine Transmembrane Transporter Activity Protein Binding Peptide:proton Symporter Activity Peptidoglycan Transmembrane Transporter Activity Dipeptide Transmembrane Transporter Activity	Transmembrane Signaling Receptor Activity Glucagon Receptor Activity Protein Binding G Protein-coupled Peptide Receptor Activity Peptide Hormone Binding Glucagon-like Peptide 1 Receptor Activity
	Biological Process	Ion Transport Protein Transport Histidine Transport Peptidoglycan Transport Mast Cell Homeostasis Positive Regulation Of Toll-like Receptor 7 Signaling Pathway Positive Regulation Of Toll-like Receptor 8 Signaling Pathway Positive Regulation Of Toll-like Receptor 9 Signaling Pathway Neutrophil Degranulation Innate Immune Response Positive Regulation Of Innate Immune Response Regulation Of Isotype Switching To IgG Isotypes Regulation Of Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Positive Regulation Of Nucleotide-binding Oligomerization Domain Containing 1 Signaling Pathway Positive Regulation Of Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway L-histidine Transmembrane Export From Vacuole Dipeptide Import Across Plasma Membrane Proton Transmembrane Transport	Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity Positive Regulation Of Cytosolic Calcium Ion Concentration CAMP-mediated Signaling Positive Regulation Of Blood Pressure Regulation Of Insulin Secretion Cellular Response To Glucagon Stimulus
Pathways		Proton/oligopeptide cotransporters Neutrophil degranulation	Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Glucagon-like Peptide-1 (GLP1) regulates insulin secretion G alpha (s) signalling events Glucagon-type ligand receptors ADORA2B mediated anti-inflammatory cytokines production
Drugs			Glucagon Exenatide Liraglutide Albiglutide Dulaglutide Lixisenatide Semaglutide
Diseases
GWAS		Basophil count ( 32888494) Basophil percentage of white cells ( 32888494) Cognitive decline rate in late mild cognitive impairment ( 26252872) Palmitic acid (16:0) levels ( 23362303) Periodontal disease related phenotype (PCT5) ( 26962152) Systemic lupus erythematosus ( 27399966 23273568 26663301 26502338 28714469 19838193 19838195)	Blood sugar levels ( 29403010) Fasting blood glucose ( 25631608) Fasting blood glucose adjusted for BMI ( 25625282) Type 2 diabetes ( 32499647)
Interacting Genes		3 interacting genes: DRD2 GLP1R GPR35	112 interacting genes: ACSF3 AGXT AIG1 APH1A ARFRP1 ASGR2 ATP13A1 ATP5MC3 ATP6AP2 C18orf32 C4orf3 CALM1 CAND2 CAV1 CCDC167 CD63 CD81 CELA3B CEND1 CFI CLDN7 CLIP4 CLPS CNIH4 COMT CYSRT1 CYSTM1 DAD1 DHRS7 EBP ELOVL1 EMC7 EMP2 ERP29 FGL1 FTL GABBR2 GCG GJB1 GNAS GP2 GPR108 GPR37 GPRASP1 GRINA HAMP HPN IER3 IFITM3 KHK KRTAP1-1 KRTAP1-3 KRTAP10-3 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP17-1 KRTAP5-9 LAPTM4A LINC00269 MFSD5 MRPL22 MT-ATP6 MT-ND4L MTCH2 MYL6 NBPF19 NOTCH2NLA NRGN NUCKS1 OCIAD2 OST4 P4HTM PAM PAQR6 PGRMC1 PIGG POMT2 PPIB PRSS2 PSMD8 RAB5B RAB5C RNF5 RTN3 RTN4 RTRAF SAA1 SCGB2A1 SEC11C SELENOK SERPINA1 SLC15A4 SLC37A4 SPTSSA STMN1 STMN3 STOML2 SVOP SYNGR3 SYNGR4 SYS1 TM4SF4 TMBIM6 TMCO3 TMEM147 TMEM176B TOMM6 TSPAN13 UGT1A9 VAPB ZNF99
Entrez ID		121260	2740
HPRD ID		11566	00677
Ensembl ID		ENSG00000139370	ENSG00000112164
Uniprot IDs		Q8N697	A0A142FHB8 P43220
PDB IDs			3C59 3C5T 3IOL 4ZGM 5E94 5NX2 5OTT 5OTU 5OTV 5OTW 5OTX 5VEW 5VEX 6B3J 6GB1 6ORV 6VCB 6X18 6X19 6X1A 7C2E
Enriched GO Terms of Interacting Partners?
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