LAMA1 and MEP1A

Data Source:
BioGRID (enzymatic study)
HPRD (in vitro)

		LAMA1	MEP1A
Description		laminin subunit alpha 1	meprin A subunit alpha
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Basement Membrane Laminin-1 Complex Laminin-3 Complex Extracellular Space Cell-cell Junction Membrane Extracellular Matrix Collagen-containing Extracellular Matrix	Extracellular Space Integral Component Of Plasma Membrane Meprin A Complex Extracellular Exosome
	Molecular Function	Signaling Receptor Binding Extracellular Matrix Structural Constituent Protein Binding Protein C-terminus Binding Glycosphingolipid Binding	Metalloendopeptidase Activity Protein Binding Zinc Ion Binding
	Biological Process	Morphogenesis Of An Epithelial Sheet Protein Phosphorylation Cell Adhesion Cell Surface Receptor Signaling Pathway Axon Guidance Animal Organ Morphogenesis Tissue Development Regulation Of Cell Adhesion Extracellular Matrix Organization Regulation Of Cell Migration Camera-type Eye Development Establishment Of Epithelial Cell Apical/basal Polarity Regulation Of Embryonic Development Blood Vessel Morphogenesis Epithelial Tube Branching Involved In Lung Morphogenesis Branching Involved In Salivary Gland Morphogenesis Retinal Blood Vessel Morphogenesis	Proteolysis
Pathways		Laminin interactions Laminin interactions Non-integrin membrane-ECM interactions ECM proteoglycans L1CAM interactions MET activates PTK2 signaling
Drugs		Lanoteplase
Diseases
GWAS		Adverse response to drug ( 30420678) Response to citalopram treatment ( 22760553) Type 2 diabetes ( 30054458 22693455 30297969 32499647)
Interacting Genes		20 interacting genes: ACHE APCS APP C3 COL7A1 DAG1 FBLN2 HSPG2 ITGA1 ITGA2 ITGB1 MEP1A NID1 NT5E PLAT PLG SAA1 SAA2 TMPRSS6 UBC	18 interacting genes: AGT CCK FN1 GCG GNRH1 GRP KNG1 LAMA1 LAMA5 MEP1B NPY NTS PLG POMC PTH SCT TAC1 VIP
Entrez ID		284217	4224
HPRD ID		01033	02666
Ensembl ID		ENSG00000101680	ENSG00000112818
Uniprot IDs		P25391	B7ZL91 Q16819
PDB IDs
Enriched GO Terms of Interacting Partners?
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