MEP1A and GRP

Data Source:
HPRD (in vitro)

		MEP1A	GRP
Description		meprin A subunit alpha	gastrin releasing peptide
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Space Integral Component Of Plasma Membrane Meprin A Complex Extracellular Exosome	Extracellular Region Extracellular Space Secretory Granule Lumen
	Molecular Function	Metalloendopeptidase Activity Protein Binding Zinc Ion Binding	Signaling Receptor Binding Neuropeptide Hormone Activity Protein Binding
	Biological Process	Proteolysis	Signal Transduction G Protein-coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Social Behavior Psychomotor Behavior Response To External Biotic Stimulus Positive Regulation Of Peptide Hormone Secretion Positive Regulation Of Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway
Pathways			Peptide ligand-binding receptors Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) G alpha (q) signalling events
Drugs
Diseases
GWAS			Adult body size ( 32376654) BMI (adjusted for smoking behaviour) ( 28443625) BMI in non-smokers ( 28443625) Body mass index ( 25673413) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Medication use (drugs used in diabetes) ( 31015401) Pancreatic cancer ( 29422604 26098869) Pancreatic ductal adenocarcinoma ( 30541042) Triglyceride levels x thiazide or thiazide-like diuretics use interaction ( 31806883) Type 2 diabetes ( 30297969) Venous thromboembolism ( 32232851)
Interacting Genes		18 interacting genes: AGT CCK FN1 GCG GNRH1 GRP KNG1 LAMA1 LAMA5 MEP1B NPY NTS PLG POMC PTH SCT TAC1 VIP	5 interacting genes: ALX1 DPP4 GRPR MEP1A MEP1B
Entrez ID		4224	2922
HPRD ID		02666	08845
Ensembl ID		ENSG00000112818	ENSG00000134443
Uniprot IDs		B7ZL91 Q16819	A0A140VJM7 P07492
PDB IDs			2N0B 2N0C 2N0D 2N0E 2N0F 2N0G 2N0H
Enriched GO Terms of Interacting Partners?
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