MEP1A and NPY

Data Source:
BioGRID (enzymatic study)

		MEP1A	NPY
Description		meprin A subunit alpha	neuropeptide Y
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Space Integral Component Of Plasma Membrane Meprin A Complex Extracellular Exosome	Extracellular Region Extracellular Space Golgi Apparatus Synapse Neuronal Dense Core Vesicle
	Molecular Function	Metalloendopeptidase Activity Protein Binding Zinc Ion Binding	G Protein-coupled Receptor Binding G Protein-coupled Receptor Activity Signaling Receptor Binding Hormone Activity Neuropeptide Hormone Activity Calcium Channel Regulator Activity Protein Binding Neuropeptide Y Receptor Binding
	Biological Process	Proteolysis	G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Neuropeptide Signaling Pathway Chemical Synaptic Transmission Feeding Behavior Regulation Of Blood Pressure Adult Feeding Behavior Central Nervous System Neuron Development Cerebral Cortex Development Neuron Projection Development Positive Regulation Of Appetite Intestinal Epithelial Cell Differentiation
Pathways			Peptide ligand-binding receptors G alpha (i) signalling events FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
Drugs			Phentermine 2-aminoisobutyric acid L-tyrosinamide
Diseases
GWAS			Adult body size ( 32376654) Aggressive periodontitis (sex interaction) ( 25256105) Body size at age 10 ( 32376654) Chronotype ( 30696823) Morning person ( 30696823) Periodontitis ( 23459936) Vitamin D levels ( 25208829)
Interacting Genes		18 interacting genes: AGT CCK FN1 GCG GNRH1 GRP KNG1 LAMA1 LAMA5 MEP1B NPY NTS PLG POMC PTH SCT TAC1 VIP	16 interacting genes: ATP12A BAG6 GHRL MC4R MEP1A MEP1B NPFF NPFFR2 NPY1R NPY2R NPY4R NPY5R NR1H2 PMCH UBQLN1 UBQLN2
Entrez ID		4224	4852
HPRD ID		02666	01214
Ensembl ID		ENSG00000112818	ENSG00000122585
Uniprot IDs		B7ZL91 Q16819	A4D158 P01303
PDB IDs			1QFA 1RON
Enriched GO Terms of Interacting Partners?
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