P4HA3 and ZC3H12A

Data Source:
BioGRID (two hybrid)

		P4HA3	ZC3H12A
Description		prolyl 4-hydroxylase subunit alpha 3	zinc finger CCCH-type containing 12A
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Lumen	P-body Nucleus Nucleoplasm Cytoplasm Rough Endoplasmic Reticulum Cytoskeleton Rough Endoplasmic Reticulum Membrane Protein-containing Complex Cytoplasmic Ribonucleoprotein Granule Extrinsic Component Of Endoplasmic Reticulum Membrane
	Molecular Function	Procollagen-proline 4-dioxygenase Activity Iron Ion Binding Protein Binding Oxidoreductase Activity, Acting On Single Donors With Incorporation Of Molecular Oxygen, Incorporation Of Two Atoms Of Oxygen L-ascorbic Acid Binding	DNA Binding Chromatin Binding RNA Binding MRNA Binding MRNA 3'-UTR Binding Endoribonuclease Activity Exoribonuclease Activity Ribonuclease Activity Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding MiRNA Binding RNA Stem-loop Binding MRNA 3'-UTR AU-rich Region Binding Ribosome Binding Metal Ion Binding
	Biological Process	Peptidyl-proline Hydroxylation To 4-hydroxy-L-proline	Nuclear-transcribed MRNA Catabolic Process, Endonucleolytic Cleavage-dependent Decay Angiogenesis Negative Regulation Of Protein Phosphorylation Positive Regulation Of Defense Response To Virus By Host Immune Response-activating Signal Transduction Apoptotic Process Inflammatory Response Cellular Response To DNA Damage Stimulus Nervous System Development Regulation Of Gene Expression Positive Regulation Of Autophagy Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Negative Regulation Of Muscle Cell Apoptotic Process Positive Regulation Of Lipid Storage Positive Regulation Of Cell Death Viral Process Protein Deubiquitination Protein Phosphopantetheinylation Cell Differentiation Negative Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Interferon-gamma Production Negative Regulation Of Interleukin-1 Beta Production Negative Regulation Of Interleukin-6 Production Negative Regulation Of Tumor Necrosis Factor Production Cellular Response To Oxidative Stress Cellular Response To Glucose Starvation Positive Regulation Of Protein Import Into Nucleus Negative Regulation Of Macrophage Activation Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation By Host Of Viral Genome Replication Negative Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Fat Cell Differentiation Positive Regulation Of Angiogenesis Positive Regulation Of Transcription By RNA Polymerase II T Cell Receptor Signaling Pathway Protein Complex Oligomerization Defense Response To Virus Negative Regulation Of Cardiac Muscle Contraction Positive Regulation Of MRNA Catabolic Process 3'-UTR-mediated MRNA Destabilization Cellular Response To Lipopolysaccharide Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor RNA Phosphodiester Bond Hydrolysis RNA Phosphodiester Bond Hydrolysis, Endonucleolytic RNA Phosphodiester Bond Hydrolysis, Exonucleolytic Cellular Response To Virus Negative Regulation Of Cytokine Production Involved In Inflammatory Response Positive Regulation Of Execution Phase Of Apoptosis Positive Regulation Of P38MAPK Cascade Negative Regulation Of NIK/NF-kappaB Signaling Positive Regulation Of Protein Deubiquitination Negative Regulation Of Production Of MiRNAs Involved In Gene Silencing By MiRNA Cellular Response To Sodium Arsenite Cellular Response To Ionomycin Cellular Response To Chemokine Negative Regulation Of T-helper 17 Cell Differentiation Positive Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of MiRNA Catabolic Process
Pathways		Collagen biosynthesis and modifying enzymes
Drugs
Diseases
GWAS		Hippocampal atrophy ( 25625606)	Eyebrow thickness ( 26926045) Mean corpuscular hemoglobin ( 32888494) Red cell distribution width ( 32888494)
Interacting Genes		50 interacting genes: ACOT8 ADRA2C ANAPC11 ATN1 B9D2 BAG4 BLOC1S2 C1orf112 C1QTNF2 CERCAM CKMT2 CLPP CT55 CTAG1A CTAG1B CTNNBIP1 DTNBP1 FAM136A GGA3 GPSM3 HGS KRTAP19-5 KRTAP6-1 KRTAP8-1 LRP2BP MAGEA2 MAGEA2B MAGEC2 MCCD1 MEOX2 MSRA NDN NICN1 NUTM1 OIP5 P4HB PROP1 PSMB4 RBFOX1 RUSC1 SCARA5 SERTAD1 SERTAD3 STMN3 TLE5 TOX2 VPS37C WDR62 ZBTB7B ZC3H12A	19 interacting genes: AHSP AIMP2 BTRC CYFIP2 DNAJB13 EP300 HIF1A IKBKG IL6 IRAK2 KPNA2 P4HA3 SHBG SMAD3 TANK TRIM55 TRIM63 UBC ZC3H12D
Entrez ID		283208	80149
HPRD ID		16413	08021
Ensembl ID		ENSG00000149380	ENSG00000163874
Uniprot IDs		Q7Z4N8	Q5D1E8
PDB IDs			3V32 3V33 3V34
Enriched GO Terms of Interacting Partners?
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