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P4HA3 and ADRA2C
Data Source:
BioGRID
(two hybrid)
P4HA3
ADRA2C
Description
prolyl 4-hydroxylase subunit alpha 3
adrenoceptor alpha 2C
Image
No pdb structure
GO Annotations
Cellular Component
Endoplasmic Reticulum
Endoplasmic Reticulum Lumen
Cytoplasm
Endosome
Plasma Membrane
Integral Component Of Plasma Membrane
Neuronal Cell Body
Axon Terminus
Glutamatergic Synapse
Integral Component Of Postsynaptic Density Membrane
Molecular Function
Procollagen-proline 4-dioxygenase Activity
Iron Ion Binding
Protein Binding
Oxidoreductase Activity, Acting On Single Donors With Incorporation Of Molecular Oxygen, Incorporation Of Two Atoms Of Oxygen
L-ascorbic Acid Binding
G Protein-coupled Receptor Activity
Alpha2-adrenergic Receptor Activity
Protein Binding
Alpha-2A Adrenergic Receptor Binding
Identical Protein Binding
Protein Homodimerization Activity
Protein Heterodimerization Activity
Epinephrine Binding
Biological Process
Peptidyl-proline Hydroxylation To 4-hydroxy-L-proline
G Protein-coupled Receptor Signaling Pathway
Cell-cell Signaling
Female Pregnancy
Negative Regulation Of Norepinephrine Secretion
Platelet Activation
Activation Of Protein Kinase B Activity
Negative Regulation Of Epinephrine Secretion
Receptor Transactivation
Positive Regulation Of MAPK Cascade
Positive Regulation Of Neuron Differentiation
Positive Regulation Of Vasoconstriction
Regulation Of Insulin Secretion
Regulation Of Sensory Perception Of Pain
Negative Regulation Of Uterine Smooth Muscle Contraction
Adrenergic Receptor Signaling Pathway
Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway
Pathways
Collagen biosynthesis and modifying enzymes
Adrenoceptors
Adrenaline signalling through Alpha-2 adrenergic receptor
Adrenaline,noradrenaline inhibits insulin secretion
G alpha (i) signalling events
G alpha (z) signalling events
Surfactant metabolism
Drugs
Amphetamine
Tramadol
Bethanidine
Ziprasidone
Cabergoline
Ropinirole
Clozapine
Norepinephrine
Phenylpropanolamine
Loxapine
Prochlorperazine
Chlorpromazine
Brimonidine
Haloperidol
Nortriptyline
Amoxapine
Clonidine
Lisuride
Ergotamine
Tizanidine
Apomorphine
Paroxetine
Risperidone
Tolazoline
Fenoldopam
Phenoxybenzamine
Maprotiline
Oxymetazoline
Ergoloid mesylate
Promethazine
Carvedilol
Desipramine
Escitalopram
Pergolide
Bromocriptine
Quetiapine
Aripiprazole
Paliperidone
Ephedra sinica root
Mephentermine
Yohimbine
Methotrimeprazine
Dextroamphetamine
Metamfetamine
Celiprolol
Dronedarone
Iloperidone
OPC-28326
Epicept NP-1
Mianserin
Pizotifen
Asenapine
Ocaperidone
Droxidopa
Esmirtazapine
Xylometazoline
Levonordefrin
Lurasidone
Agmatine
Brexpiprazole
Dosulepin
Etoperidone
Lorpiprazole
Cirazoline
Moxisylyte
Aranidipine
Setiptiline
Racepinephrine
Dihydroergocornine
DL-Methylephedrine
Xylazine
Indigotindisulfonic acid
Tiapride
Dihydroergocristine
Aripiprazole lauroxil
Diseases
GWAS
Hippocampal atrophy (
25625606
)
Blood urea nitrogen levels (
31152163
)
Lung cancer in ever smokers (
28604730
)
Nickel levels (
26025379
)
Urinary potassium excretion (
31409800
)
Interacting Genes
50 interacting genes:
ACOT8
ADRA2C
ANAPC11
ATN1
B9D2
BAG4
BLOC1S2
C1orf112
C1QTNF2
CERCAM
CKMT2
CLPP
CT55
CTAG1A
CTAG1B
CTNNBIP1
DTNBP1
FAM136A
GGA3
GPSM3
HGS
KRTAP19-5
KRTAP6-1
KRTAP8-1
LRP2BP
MAGEA2
MAGEA2B
MAGEC2
MCCD1
MEOX2
MSRA
NDN
NICN1
NUTM1
OIP5
P4HB
PROP1
PSMB4
RBFOX1
RUSC1
SCARA5
SERTAD1
SERTAD3
STMN3
TLE5
TOX2
VPS37C
WDR62
ZBTB7B
ZC3H12A
17 interacting genes:
CCDC24
CHCHD2
CNPY2
EIF2B1
GNAO1
HGS
KLHL38
KRT34
MDFI
MEIS2
MGAT5B
MKRN3
P4HA3
PPP1R9B
UCHL1
WWOX
YWHAZ
Entrez ID
283208
152
HPRD ID
16413
00085
Ensembl ID
ENSG00000149380
ENSG00000184160
Uniprot IDs
Q7Z4N8
P18825
Q4W594
PDB IDs
6KUW
Enriched GO Terms of Interacting Partners
?
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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