DISC1 and PKN1

Data Source:
BioGRID (two hybrid)

		DISC1	PKN1
Description		DISC1 scaffold protein	protein kinase N1
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GO Annotations	Cellular Component	Nucleus Mitochondrion Endoplasmic Reticulum Centrosome Cytosol Kinesin Complex Microtubule Synaptic Vesicle Postsynaptic Density Dynein Complex Ciliary Basal Body Cell Body Intermediate Filament Cytoskeleton Perinuclear Region Of Cytoplasm Central Region Of Growth Cone Ciliary Base	Nucleus Nucleoplasm Cytoplasm Endosome Cytosol Midbody Cleavage Furrow Protein-containing Complex
	Molecular Function	Protein Binding Kinesin Binding Protein-containing Complex Binding Molecular Adaptor Activity	Chromatin Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Calcium-dependent Protein Kinase C Activity Protein Kinase C Binding Protein Binding ATP Binding Nuclear Receptor Coactivator Activity Small GTPase Binding Histone Kinase Activity (H3-T11 Specific) Histone Binding Histone Deacetylase Binding Androgen Receptor Binding
	Biological Process	Microtubule Cytoskeleton Organization Neuron Migration Positive Regulation Of Cell-matrix Adhesion Positive Regulation Of Neuroblast Proliferation Regulation Of Neuron Projection Development Positive Regulation Of Neuron Projection Development Cell Proliferation In Forebrain Pyramidal Neuron Migration Positive Regulation Of Wnt Signaling Pathway TOR Signaling Negative Regulation Of Protein Binding Positive Regulation Of Axon Extension Mitochondrial Calcium Ion Homeostasis Response To Electrical Stimulus Regulation Of Synaptic Transmission, Glutamatergic Canonical Wnt Signaling Pathway Cilium Assembly Regulation Of Dendritic Spine Development Protein Localization To Centrosome Regulation Of Synapse Maturation Non-motile Cilium Assembly Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process	B Cell Homeostasis B Cell Apoptotic Process Regulation Of Germinal Center Formation Regulation Of Immunoglobulin Production Renal System Process Regulation Of Transcription By RNA Polymerase II Protein Phosphorylation Negative Regulation Of Protein Kinase Activity Hyperosmotic Response Signal Transduction Activation Of JUN Kinase Activity Epithelial Cell Migration Peptidyl-serine Phosphorylation Negative Regulation Of B Cell Proliferation Histone H3-T11 Phosphorylation Intracellular Signal Transduction Positive Regulation Of Transcription, DNA-templated Spleen Development Regulation Of Cell Motility
Pathways			RHO GTPases activate PKNs Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
Drugs			Fostamatinib
Diseases
GWAS		Alzheimer's disease ( 19118814) Amyotrophic lateral sclerosis ( 19451621) Amyotrophic lateral sclerosis (sporadic) ( 24529757) Arterial stiffness index ( 31235810) Chronic periodontitis (mean interproximal clinical attachment level) ( 27601451) Metabolite levels ( 23823483) Neuranatomic and neurocognitive phenotypes ( 21483430) Pelvic organ prolapse (moderate/severe) ( 26545240) Response to antidepressants (symptom improvement) ( 29160301) Response to antineoplastic agents ( 21659360) Response to statin therapy ( 20339536) Serum docosahexaenoic fatty acid concentration in metabolic syndrome ( 31991592) Waist circumference ( 28552196)	Pancreatic cancer ( 30206226) Urolithiasis ( 30975718)
Interacting Genes		188 interacting genes: ABI2 ACTG1 ACTN2 ADO AGTPBP1 AIMP2 AKAP6 AMOT AP1M1 ARIH2 ARMC7 ATF4 ATF5 ATF7IP BAG2 BFSP2 BICD1 BORCS6 BRD1 C1orf109 C2CD6 C8orf33 CARD9 CCDC102B CCDC13 CCDC136 CCDC141 CCDC197 CCDC24 CCDC57 CCDC88A CCDC92 CCHCR1 CDC23 CDC37 CDC5L CDK5RAP3 CDKL3 CEP126 CEP57 CEP57L1 CEP63 CFAP206 CIT CLU COL4A1 CTNNA3 CWF19L2 DCTN1 DCTN2 DDX6 DMD DNAJC7 DPYSL2 DPYSL3 DST DYNC1H1 EEF2 EIF3H EIF4A3 EMSY EXOC1 EXOC4 EXOC7 FBXO34 FBXO41 FBXW7 FEZ1 FLACC1 FRYL GABARAPL1 GAS2L2 GAS8 GCC1 GEM GNB1 GNG13 GNPTAB GPANK1 GPRASP2 GRIPAP1 GSK3B HERC2P2 HNRNPC IFT20 IFT74 IMMT ITSN1 KALRN KANSL1 KCNQ5 KIF3A KIF3C KIF9 KIFAP3 KIFC3 LENG1 MACF1 MAP1A MEMO1 MLLT10 MNS1 MORF4L2 MPPED1 MVP MYH7 MYT1L NCK2 NDE1 NDEL1 NECAB1 NEFM NME7 NSRP1 NUP160 OLFM1 PCNT PCNX4 PDE4B PGK1 PHF1 PIBF1 PIK3R3 PKN1 POLR3C PPFIA3 PPM1E PPP4R1 PPP5C PSPC1 QARS1 RABGAP1 RAD21 RANBP9 RASSF7 RBM41 RBSN RECK RNF40 ROGDI RTRAF SH3BP5 SMARCD1 SMARCE1 SMC2 SMC3 SMC5 SMYD1 SNX6 SPARCL1 SPATC1L SPTBN4 SRGAP2 SRGAP3 STX11 STX18 SUFU SYBU SYNE1 TCAF1 TCEANC TFIP11 TIAM2 TNKS TRAF3IP1 TRAF4 TRIM29 TRIM68 TRIO TSGA10 TSPOAP1 TSR2 TTC23 TUBB TUBB2A UBASH3A UBASH3B USP2 UTRN XPNPEP1 YWHAE YWHAG YWHAQ YWHAZ ZNF124 ZNF197 ZNF365 ZNF76	83 interacting genes: ACTN1 ADAMTSL4 AKAP9 ARHGAP10 ARHGAP26 ARSA BLZF1 BUD23 CASP3 CCDC103 CCDC136 CCDC138 CCDC85B CCNT2 CD44 CDC25C CDR2 CEP57 CEP57L1 CEP70 CYSRT1 DISC1 DYDC1 EIF3F GOLGA2 GOLGA6L9 H3C14 HAP1 HAUS1 HDAC5 HOMER3 HSF2BP INTS11 KIAA1328 KRT15 KRT16 KRT19 KRT31 KRT34 KRT35 KRT36 KRT37 LRRC61 MAP2K6 MAPK12 MAPT MARCKS MBP MID1 MID2 MIPOL1 MKRN3 MTDH MTUS2 NEFH NEFL NEUROD2 PDPK1 PICK1 PLD1 PNMA1 POU6F2 PSMB4 RAB3IP RHOA SERTAD3 SMYD3 SPAG5 SPRR2D SSX2IP STX11 SYCE3 TNFRSF1B TRAF1 TRAF2 TRIM27 TSGA10 UBR2 USHBP1 VIM ZFAND6 ZNF282 ZRANB1
Entrez ID		27185	5585
HPRD ID		05553	03019
Ensembl ID		ENSG00000162946	ENSG00000123143
Uniprot IDs		C4P094 C4P096 C4P098 C4P0A4 C4P0A5 C4P0C4 C4P0C8 C4P0D0 C4P0D1 C4P0D2 C4P0D3 Q9NRI5	Q16512
PDB IDs		5V4B	1CXZ 1URF 2RMK 4NKG 4OTD 4OTG 4OTH 4OTI
Enriched GO Terms of Interacting Partners?
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