PKN1 and UBR2

Data Source:
BioGRID (two hybrid)

		PKN1	UBR2
Description		protein kinase N1	ubiquitin protein ligase E3 component n-recognin 2
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Endosome Cytosol Midbody Cleavage Furrow Protein-containing Complex	Ubiquitin Ligase Complex Chromatin Nucleus Cytoplasm Cytosol
	Molecular Function	Chromatin Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Calcium-dependent Protein Kinase C Activity Protein Kinase C Binding Protein Binding ATP Binding Nuclear Receptor Coactivator Activity Small GTPase Binding Histone Kinase Activity (H3-T11 Specific) Histone Binding Histone Deacetylase Binding Androgen Receptor Binding	Protein Binding Zinc Ion Binding Ubiquitin Protein Ligase Activity Leucine Binding
	Biological Process	B Cell Homeostasis B Cell Apoptotic Process Regulation Of Germinal Center Formation Regulation Of Immunoglobulin Production Renal System Process Regulation Of Transcription By RNA Polymerase II Protein Phosphorylation Negative Regulation Of Protein Kinase Activity Hyperosmotic Response Signal Transduction Activation Of JUN Kinase Activity Epithelial Cell Migration Peptidyl-serine Phosphorylation Negative Regulation Of B Cell Proliferation Histone H3-T11 Phosphorylation Intracellular Signal Transduction Positive Regulation Of Transcription, DNA-templated Spleen Development Regulation Of Cell Motility	Protein Polyubiquitination Chromatin Silencing Reciprocal Meiotic Recombination Male Meiotic Nuclear Division Male Meiosis I Spermatogenesis Negative Regulation Of Transposition Protein Ubiquitination Negative Regulation Of TOR Signaling Histone H2A Ubiquitination Cellular Response To Leucine Ubiquitin-dependent Protein Catabolic Process Via The N-end Rule Pathway
Pathways		RHO GTPases activate PKNs Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3	Antigen processing: Ubiquitination & Proteasome degradation
Drugs		Fostamatinib
Diseases
GWAS		Pancreatic cancer ( 30206226) Urolithiasis ( 30975718)	Lung cancer in never smokers ( 28604730) Obesity-related traits ( 23251661) Serum total protein level ( 29403010)
Interacting Genes		83 interacting genes: ACTN1 ADAMTSL4 AKAP9 ARHGAP10 ARHGAP26 ARSA BLZF1 BUD23 CASP3 CCDC103 CCDC136 CCDC138 CCDC85B CCNT2 CD44 CDC25C CDR2 CEP57 CEP57L1 CEP70 CYSRT1 DISC1 DYDC1 EIF3F GOLGA2 GOLGA6L9 H3C14 HAP1 HAUS1 HDAC5 HOMER3 HSF2BP INTS11 KIAA1328 KRT15 KRT16 KRT19 KRT31 KRT34 KRT35 KRT36 KRT37 LRRC61 MAP2K6 MAPK12 MAPT MARCKS MBP MID1 MID2 MIPOL1 MKRN3 MTDH MTUS2 NEFH NEFL NEUROD2 PDPK1 PICK1 PLD1 PNMA1 POU6F2 PSMB4 RAB3IP RHOA SERTAD3 SMYD3 SPAG5 SPRR2D SSX2IP STX11 SYCE3 TNFRSF1B TRAF1 TRAF2 TRIM27 TSGA10 UBR2 USHBP1 VIM ZFAND6 ZNF282 ZRANB1	9 interacting genes: H2AC20 H2BC8 NTAN1 NTAQ1 PKN1 SUOX UBE2B UBE2D2 UBE2H
Entrez ID		5585	23304
HPRD ID		03019	09853
Ensembl ID		ENSG00000123143	ENSG00000024048
Uniprot IDs		Q16512	B3KXG6 Q8IWV8
PDB IDs		1CXZ 1URF 2RMK 4NKG 4OTD 4OTG 4OTH 4OTI	3NY2 3NY3 5TDA 5TDB 5TDD 5UM3
Enriched GO Terms of Interacting Partners?
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