Wiki-MPM
About
Search
Browse
People
Funding
Updates
Search
PKN1 and HDAC5
Data Source:
BioGRID
(enzymatic study)
PKN1
HDAC5
Description
protein kinase N1
histone deacetylase 5
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Endosome
Cytosol
Midbody
Cleavage Furrow
Protein-containing Complex
Histone Deacetylase Complex
Nucleus
Nucleoplasm
Cytoplasm
Golgi Apparatus
Cytosol
Nuclear Speck
Molecular Function
Chromatin Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Calcium-dependent Protein Kinase C Activity
Protein Kinase C Binding
Protein Binding
ATP Binding
Nuclear Receptor Coactivator Activity
Small GTPase Binding
Histone Kinase Activity (H3-T11 Specific)
Histone Binding
Histone Deacetylase Binding
Androgen Receptor Binding
Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Transcription Factor Binding
Chromatin Binding
Histone Deacetylase Activity
Protein Kinase C Binding
Protein Binding
Transcription Factor Binding
NAD-dependent Histone Deacetylase Activity (H3-K14 Specific)
Protein Deacetylase Activity
Identical Protein Binding
Histone Deacetylase Binding
Metal Ion Binding
Repressing Transcription Factor Binding
Biological Process
B Cell Homeostasis
B Cell Apoptotic Process
Regulation Of Germinal Center Formation
Regulation Of Immunoglobulin Production
Renal System Process
Regulation Of Transcription By RNA Polymerase II
Protein Phosphorylation
Negative Regulation Of Protein Kinase Activity
Hyperosmotic Response
Signal Transduction
Activation Of JUN Kinase Activity
Epithelial Cell Migration
Peptidyl-serine Phosphorylation
Negative Regulation Of B Cell Proliferation
Histone H3-T11 Phosphorylation
Intracellular Signal Transduction
Positive Regulation Of Transcription, DNA-templated
Spleen Development
Regulation Of Cell Motility
Negative Regulation Of Transcription By RNA Polymerase II
Chromatin Organization
Chromatin Remodeling
Chromatin Silencing
Protein Deacetylation
Inflammatory Response
Regulation Of Myotube Differentiation
Negative Regulation Of Myotube Differentiation
Response To Activity
Histone Deacetylation
Neuron Differentiation
B Cell Differentiation
Cellular Response To Insulin Stimulus
Regulation Of Gene Expression, Epigenetic
B Cell Activation
Response To Cocaine
Response To Drug
Regulation Of Protein Binding
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of DNA-binding Transcription Factor Activity
Histone H3 Deacetylation
Cellular Response To Lipopolysaccharide
Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis
Regulation Of Histone H3-K9 Acetylation
Pathways
RHO GTPases activate PKNs
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
NOTCH1 Intracellular Domain Regulates Transcription
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
Notch-HLH transcription pathway
Regulation of PTEN gene transcription
Drugs
Fostamatinib
Belinostat
Panobinostat
Diseases
GWAS
Pancreatic cancer (
30206226
)
Urolithiasis (
30975718
)
Apolipoprotein A1 levels (
32203549
)
Bipolar disorder (
31043756
)
Bone mineral density (hip) (
19801982
)
Bone mineral density (spine) (
19801982
)
HDL cholesterol levels (
32203549
)
Heel bone mineral density (
30598549
28869591
)
Mean platelet volume (
32888494
)
Interacting Genes
83 interacting genes:
ACTN1
ADAMTSL4
AKAP9
ARHGAP10
ARHGAP26
ARSA
BLZF1
BUD23
CASP3
CCDC103
CCDC136
CCDC138
CCDC85B
CCNT2
CD44
CDC25C
CDR2
CEP57
CEP57L1
CEP70
CYSRT1
DISC1
DYDC1
EIF3F
GOLGA2
GOLGA6L9
H3C14
HAP1
HAUS1
HDAC5
HOMER3
HSF2BP
INTS11
KIAA1328
KRT15
KRT16
KRT19
KRT31
KRT34
KRT35
KRT36
KRT37
LRRC61
MAP2K6
MAPK12
MAPT
MARCKS
MBP
MID1
MID2
MIPOL1
MKRN3
MTDH
MTUS2
NEFH
NEFL
NEUROD2
PDPK1
PICK1
PLD1
PNMA1
POU6F2
PSMB4
RAB3IP
RHOA
SERTAD3
SMYD3
SPAG5
SPRR2D
SSX2IP
STX11
SYCE3
TNFRSF1B
TRAF1
TRAF2
TRIM27
TSGA10
UBR2
USHBP1
VIM
ZFAND6
ZNF282
ZRANB1
61 interacting genes:
ANKRA2
ANKRD11
ATF3
BCL6
BCOR
BRMS1
CAMK1
CAMTA2
CBX5
CIITA
CTBP1
DDX20
DYRK1B
EEF1G
ESR1
GABARAP
GATA1
GATA2
GCM1
GNB1
H3C1
HDAC3
HDAC7
HIF1A
HOXC11
HR
JDP2
KLF4
LMO2
MAFF
MEF2A
MEF2C
MEF2D
NCOR1
NCOR2
NFATC1
NFKB2
NFKBIE
NRIP1
PHB2
PKN1
PKN2
PRKAA1
PRKCD
PRKD1
RFXANK
RUNX3
SFN
SIK1
SIK2
SIK3
SLC2A4RG
SMAD3
SUV39H1
TAB2
UBC
UBE2I
YWHAB
YWHAE
YWHAQ
ZBTB16
Entrez ID
5585
10014
HPRD ID
03019
09246
Ensembl ID
ENSG00000123143
ENSG00000108840
Uniprot IDs
Q16512
Q9UQL6
PDB IDs
1CXZ
1URF
2RMK
4NKG
4OTD
4OTG
4OTH
4OTI
5UWI
Enriched GO Terms of Interacting Partners
?
Tagcloud
?
Tagcloud (Difference)
?
Tagcloud (Intersection)
?