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PKN1 and SPAG5
Data Source:
BioGRID
(two hybrid)
PKN1
SPAG5
Description
protein kinase N1
sperm associated antigen 5
Image
No pdb structure
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Endosome
Cytosol
Midbody
Cleavage Furrow
Protein-containing Complex
Kinetochore
Condensed Chromosome Kinetochore
Cytoplasm
Cytosol
Nuclear Body
Midbody
Centriolar Satellite
Microtubule Plus-end
Mitotic Spindle
Mitotic Spindle Pole
Molecular Function
Chromatin Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Calcium-dependent Protein Kinase C Activity
Protein Kinase C Binding
Protein Binding
ATP Binding
Nuclear Receptor Coactivator Activity
Small GTPase Binding
Histone Kinase Activity (H3-T11 Specific)
Histone Binding
Histone Deacetylase Binding
Androgen Receptor Binding
Protein Binding
Microtubule Binding
Biological Process
B Cell Homeostasis
B Cell Apoptotic Process
Regulation Of Germinal Center Formation
Regulation Of Immunoglobulin Production
Renal System Process
Regulation Of Transcription By RNA Polymerase II
Protein Phosphorylation
Negative Regulation Of Protein Kinase Activity
Hyperosmotic Response
Signal Transduction
Activation Of JUN Kinase Activity
Epithelial Cell Migration
Peptidyl-serine Phosphorylation
Negative Regulation Of B Cell Proliferation
Histone H3-T11 Phosphorylation
Intracellular Signal Transduction
Positive Regulation Of Transcription, DNA-templated
Spleen Development
Regulation Of Cell Motility
Mitotic Sister Chromatid Segregation
Spindle Organization
Chromosome Segregation
Positive Regulation Of Intracellular Transport
Cell Division
Regulation Of Attachment Of Spindle Microtubules To Kinetochore
Protein Localization To Centrosome
Regulation Of Metaphase Plate Congression
Positive Regulation Of Spindle Assembly
Pathways
RHO GTPases activate PKNs
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
Drugs
Fostamatinib
Diseases
GWAS
Pancreatic cancer (
30206226
)
Urolithiasis (
30975718
)
Interacting Genes
83 interacting genes:
ACTN1
ADAMTSL4
AKAP9
ARHGAP10
ARHGAP26
ARSA
BLZF1
BUD23
CASP3
CCDC103
CCDC136
CCDC138
CCDC85B
CCNT2
CD44
CDC25C
CDR2
CEP57
CEP57L1
CEP70
CYSRT1
DISC1
DYDC1
EIF3F
GOLGA2
GOLGA6L9
H3C14
HAP1
HAUS1
HDAC5
HOMER3
HSF2BP
INTS11
KIAA1328
KRT15
KRT16
KRT19
KRT31
KRT34
KRT35
KRT36
KRT37
LRRC61
MAP2K6
MAPK12
MAPT
MARCKS
MBP
MID1
MID2
MIPOL1
MKRN3
MTDH
MTUS2
NEFH
NEFL
NEUROD2
PDPK1
PICK1
PLD1
PNMA1
POU6F2
PSMB4
RAB3IP
RHOA
SERTAD3
SMYD3
SPAG5
SPRR2D
SSX2IP
STX11
SYCE3
TNFRSF1B
TRAF1
TRAF2
TRIM27
TSGA10
UBR2
USHBP1
VIM
ZFAND6
ZNF282
ZRANB1
55 interacting genes:
AMOTL2
ARNT2
ATN1
BARD1
C1orf109
CCDC33
CCHCR1
CDC20B
CDK1
CENPH
CHCHD3
DCX
EIF4E2
EIF4ENIF1
ENKD1
FBXO28
FMR1
GEM
GOLGA8EP
GOLGA8F
HAUS1
IGFN1
IQCE
KANSL1
KRT3
KRT75
LGALS14
LINGO1
MID1
MID2
NEBL
NLGN3
ODF1
ORC6
PIMREG
PKN1
PLK4
POLR2L
POM121
RBM41
SH2D4A
SMARCE1
SNAP47
SNAPIN
SPAG5-AS1
TSHZ3
TTC23
ZC2HC1C
ZFC3H1
ZFYVE26
ZGPAT
ZMAT2
ZNF385C
ZNF572
ZNF688
Entrez ID
5585
10615
HPRD ID
03019
10246
Ensembl ID
ENSG00000123143
ENSG00000076382
Uniprot IDs
Q16512
Q96R06
PDB IDs
1CXZ
1URF
2RMK
4NKG
4OTD
4OTG
4OTH
4OTI
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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