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DISC1 and DCTN2
Data Source:
BioGRID
(two hybrid)
DISC1
DCTN2
Description
DISC1 scaffold protein
dynactin subunit 2
Image
No pdb structure
GO Annotations
Cellular Component
Nucleus
Mitochondrion
Endoplasmic Reticulum
Centrosome
Cytosol
Kinesin Complex
Microtubule
Synaptic Vesicle
Postsynaptic Density
Dynein Complex
Ciliary Basal Body
Cell Body
Intermediate Filament Cytoskeleton
Perinuclear Region Of Cytoplasm
Central Region Of Growth Cone
Ciliary Base
Kinetochore
Cytoplasm
Centrosome
Cytosol
Dynactin Complex
Microtubule
Membrane
Dynein Complex
Growth Cone
Vesicle
Extracellular Exosome
Molecular Function
Protein Binding
Kinesin Binding
Protein-containing Complex Binding
Molecular Adaptor Activity
Motor Activity
Protein Binding
Protein Kinase Binding
Spectrin Binding
Identical Protein Binding
Biological Process
Microtubule Cytoskeleton Organization
Neuron Migration
Positive Regulation Of Cell-matrix Adhesion
Positive Regulation Of Neuroblast Proliferation
Regulation Of Neuron Projection Development
Positive Regulation Of Neuron Projection Development
Cell Proliferation In Forebrain
Pyramidal Neuron Migration
Positive Regulation Of Wnt Signaling Pathway
TOR Signaling
Negative Regulation Of Protein Binding
Positive Regulation Of Axon Extension
Mitochondrial Calcium Ion Homeostasis
Response To Electrical Stimulus
Regulation Of Synaptic Transmission, Glutamatergic
Canonical Wnt Signaling Pathway
Cilium Assembly
Regulation Of Dendritic Spine Development
Protein Localization To Centrosome
Regulation Of Synapse Maturation
Non-motile Cilium Assembly
Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process
G2/M Transition Of Mitotic Cell Cycle
Endoplasmic Reticulum To Golgi Vesicle-mediated Transport
Mitotic Spindle Organization
Mitotic Metaphase Plate Congression
Regulation Of G2/M Transition Of Mitotic Cell Cycle
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II
Melanosome Transport
Protein Localization To Centrosome
Ciliary Basal Body-plasma Membrane Docking
Pathways
MHC class II antigen presentation
Regulation of PLK1 Activity at G2/M Transition
HSP90 chaperone cycle for steroid hormone receptors (SHR)
Loss of Nlp from mitotic centrosomes
Recruitment of mitotic centrosome proteins and complexes
Loss of proteins required for interphase microtubule organization from the centrosome
Recruitment of NuMA to mitotic centrosomes
Anchoring of the basal body to the plasma membrane
COPI-mediated anterograde transport
COPI-independent Golgi-to-ER retrograde traffic
AURKA Activation by TPX2
Drugs
Diseases
GWAS
Alzheimer's disease (
19118814
)
Amyotrophic lateral sclerosis (
19451621
)
Amyotrophic lateral sclerosis (sporadic) (
24529757
)
Arterial stiffness index (
31235810
)
Chronic periodontitis (mean interproximal clinical attachment level) (
27601451
)
Metabolite levels (
23823483
)
Neuranatomic and neurocognitive phenotypes (
21483430
)
Pelvic organ prolapse (moderate/severe) (
26545240
)
Response to antidepressants (symptom improvement) (
29160301
)
Response to antineoplastic agents (
21659360
)
Response to statin therapy (
20339536
)
Serum docosahexaenoic fatty acid concentration in metabolic syndrome (
31991592
)
Waist circumference (
28552196
)
Brain morphology (MOSTest) (
32665545
)
Interacting Genes
188 interacting genes:
ABI2
ACTG1
ACTN2
ADO
AGTPBP1
AIMP2
AKAP6
AMOT
AP1M1
ARIH2
ARMC7
ATF4
ATF5
ATF7IP
BAG2
BFSP2
BICD1
BORCS6
BRD1
C1orf109
C2CD6
C8orf33
CARD9
CCDC102B
CCDC13
CCDC136
CCDC141
CCDC197
CCDC24
CCDC57
CCDC88A
CCDC92
CCHCR1
CDC23
CDC37
CDC5L
CDK5RAP3
CDKL3
CEP126
CEP57
CEP57L1
CEP63
CFAP206
CIT
CLU
COL4A1
CTNNA3
CWF19L2
DCTN1
DCTN2
DDX6
DMD
DNAJC7
DPYSL2
DPYSL3
DST
DYNC1H1
EEF2
EIF3H
EIF4A3
EMSY
EXOC1
EXOC4
EXOC7
FBXO34
FBXO41
FBXW7
FEZ1
FLACC1
FRYL
GABARAPL1
GAS2L2
GAS8
GCC1
GEM
GNB1
GNG13
GNPTAB
GPANK1
GPRASP2
GRIPAP1
GSK3B
HERC2P2
HNRNPC
IFT20
IFT74
IMMT
ITSN1
KALRN
KANSL1
KCNQ5
KIF3A
KIF3C
KIF9
KIFAP3
KIFC3
LENG1
MACF1
MAP1A
MEMO1
MLLT10
MNS1
MORF4L2
MPPED1
MVP
MYH7
MYT1L
NCK2
NDE1
NDEL1
NECAB1
NEFM
NME7
NSRP1
NUP160
OLFM1
PCNT
PCNX4
PDE4B
PGK1
PHF1
PIBF1
PIK3R3
PKN1
POLR3C
PPFIA3
PPM1E
PPP4R1
PPP5C
PSPC1
QARS1
RABGAP1
RAD21
RANBP9
RASSF7
RBM41
RBSN
RECK
RNF40
ROGDI
RTRAF
SH3BP5
SMARCD1
SMARCE1
SMC2
SMC3
SMC5
SMYD1
SNX6
SPARCL1
SPATC1L
SPTBN4
SRGAP2
SRGAP3
STX11
STX18
SUFU
SYBU
SYNE1
TCAF1
TCEANC
TFIP11
TIAM2
TNKS
TRAF3IP1
TRAF4
TRIM29
TRIM68
TRIO
TSGA10
TSPOAP1
TSR2
TTC23
TUBB
TUBB2A
UBASH3A
UBASH3B
USP2
UTRN
XPNPEP1
YWHAE
YWHAG
YWHAQ
YWHAZ
ZNF124
ZNF197
ZNF365
ZNF76
35 interacting genes:
ABI2
BICD1
BICD2
BLOC1S1
BLOC1S2
BLOC1S6
BORCS6
CALM1
CCDC172
CENPH
CEP44
COG3
DISC1
EGFR
GADD45A
GADD45G
GNAO1
GOLM1
GRB2
GSK3B
HAUS1
HGS
KIFC3
KPNA2
MAPK6
MAPRE3
MARCKSL1
PAFAH1B1
RABGEF1
RINT1
RPGR
SMARCD1
TXLNB
USHBP1
ZW10
Entrez ID
27185
10540
HPRD ID
05553
09568
Ensembl ID
ENSG00000162946
ENSG00000175203
Uniprot IDs
C4P094
C4P096
C4P098
C4P0A4
C4P0A5
C4P0C4
C4P0C8
C4P0D0
C4P0D1
C4P0D2
C4P0D3
Q9NRI5
A0A384MDU9
A8K8J9
B3KTX4
Q13561
V9HW58
PDB IDs
5V4B
Enriched GO Terms of Interacting Partners
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