CHMP2A and VPS4B

Data Source:
HPRD (two hybrid, in vitro)

		CHMP2A	VPS4B
Description		charged multivesicular body protein 2A	vacuolar protein sorting 4 homolog B
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin ESCRT III Complex Nuclear Envelope Multivesicular Body Cytosol Membrane Membrane Coat Late Endosome Membrane Extracellular Exosome	Spindle Pole Nucleus Cytoplasm Endosome Centrosome Cytosol Endosome Membrane Late Endosome Membrane Extracellular Exosome Flemming Body
	Molecular Function	Protein Binding Protein Domain Specific Binding Phosphatidylcholine Binding	Protein Binding ATP Binding Protein C-terminus Binding Microtubule-severing ATPase Activity ATPase Activity Identical Protein Binding Protein Homodimerization Activity Protein-containing Complex Binding
	Biological Process	Nucleus Organization Mitotic Metaphase Plate Congression Membrane Invagination Exit From Mitosis Regulation Of Centrosome Duplication Protein Transport Endosomal Transport Macroautophagy Viral Life Cycle Nuclear Envelope Reassembly Endosome Transport Via Multivesicular Body Sorting Pathway Multivesicular Body Assembly Viral Budding Via Host ESCRT Complex Establishment Of Protein Localization Late Endosome To Vacuole Transport Regulation Of Viral Process Protein Polymerization Protein Homooligomerization Negative Regulation Of Cell Death Midbody Abscission Regulation Of Mitotic Spindle Assembly Positive Regulation Of Viral Release From Host Cell Positive Regulation Of Exosomal Secretion Negative Regulation Of Centriole Elongation ESCRT III Complex Disassembly	Potassium Ion Transport Nucleus Organization Mitotic Metaphase Plate Congression Regulation Of Centrosome Duplication Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Protein Transport Endosomal Transport Macroautophagy Viral Life Cycle Viral Release From Host Cell Cholesterol Transport Cytoplasmic Microtubule Organization Endosome To Lysosome Transport Via Multivesicular Body Sorting Pathway Response To Lipid Multivesicular Body Assembly Viral Budding Via Host ESCRT Complex Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Positive Regulation Of Viral Process Regulation Of Viral Process Microtubule Severing Protein Depolymerization Negative Regulation Of Cell Death Late Endosomal Microautophagy Midbody Abscission Ubiquitin-independent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Regulation Of Mitotic Spindle Assembly Positive Regulation Of Viral Release From Host Cell Negative Regulation Of Exosomal Secretion Positive Regulation Of Exosomal Secretion Positive Regulation Of Centriole Elongation Positive Regulation Of Viral Life Cycle ESCRT III Complex Disassembly
Pathways		Budding and maturation of HIV virion Macroautophagy Lysosome Vesicle Biogenesis Endosomal Sorting Complex Required For Transport (ESCRT) HCMV Late Events Late endosomal microautophagy Sealing of the nuclear envelope (NE) by ESCRT-III Translation of Replicase and Assembly of the Replication Transcription Complex Translation of Replicase and Assembly of the Replication Transcription Complex	Budding and maturation of HIV virion Endosomal Sorting Complex Required For Transport (ESCRT)
Drugs
Diseases
GWAS		Mean corpuscular hemoglobin ( 32888494)	Pyoderma gangrenosum in inflammatory bowel disease ( 24487271)
Interacting Genes		13 interacting genes: CHMP3 DOCK8 E2F4 EIF2B5 MITD1 NOL4 STAMBP TGFB3 UFD1 USP54 USP8 VPS4A VPS4B	8 interacting genes: CHMP1A CHMP1B CHMP2A CHMP5 HTRA2 KATNAL1 VPS4A ZFYVE19
Entrez ID		27243	9525
HPRD ID		12520	15653
Ensembl ID		ENSG00000130724	ENSG00000119541
Uniprot IDs		A0A024R4S0 O43633	A0A024R2C5 O75351
PDB IDs			1WR0 1XWI 2CPT 2JQH 2JQK 4U7Y
Enriched GO Terms of Interacting Partners?
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