DKK3 and PPM1D

Data Source:
BioGRID (two hybrid)

		DKK3	PPM1D
Description		dickkopf WNT signaling pathway inhibitor 3	protein phosphatase, Mg2+/Mn2+ dependent 1D
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Space	Nucleus Nucleoplasm Nucleolus Cytosol
	Molecular Function	Protein Binding Co-receptor Binding Receptor Antagonist Activity	Protein Serine/threonine Kinase Activity Protein Serine/threonine Phosphatase Activity Protein Binding Metal Ion Binding Mitogen-activated Protein Kinase Binding Protein Serine Phosphatase Activity Protein Threonine Phosphatase Activity
	Biological Process	Anatomical Structure Morphogenesis Wnt Signaling Pathway Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Adrenal Gland Development Negative Regulation Of Aldosterone Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Anti-Mullerian Hormone Signaling Pathway Negative Regulation Of Cortisol Biosynthetic Process Negative Regulation Of Signaling Receptor Activity	G2/M Transition Of Mitotic Cell Cycle DNA Methylation Chromatin Silencing Transcription Initiation From RNA Polymerase II Promoter Protein Phosphorylation Protein Dephosphorylation Negative Regulation Of Cell Population Proliferation Cellular Response To Starvation Response To Radiation Response To Bacterium DNA Damage Response, Signal Transduction By P53 Class Mediator Peptidyl-threonine Dephosphorylation Negative Regulation Of Gene Expression, Epigenetic
Pathways			Transcriptional regulation by RUNX2
Drugs
Diseases
GWAS		Blood protein levels ( 30072576 29875488) Metabolite levels (Dihydroxy docosatrienoic acid) ( 23934736) Non-response to selective serotonin reuptake inhibitors and depression ( 27622933) Response to perphenazine in schizophrenia ( 29503163) Response to taxane treatment (docetaxel) ( 23006423) Visceral fat ( 22589738)	Blood urea nitrogen levels ( 31152163)
Interacting Genes		10 interacting genes: APC AURKA BCAR3 ESR2 FZR1 IDH1 PPM1D SGTA SMAD4 UBQLN4	24 interacting genes: BEX2 CASZ1 CHEK2 DIRAS3 DKK3 EPSTI1 ERRFI1 GLCE H3-3A H3C1 ITIH5 KDM1A LYPD3 MAPK11 MDM2 MRC2 NAT2 NCL NSD3 OSGIN1 RHOBTB2 RPL5 TP53 UBC
Entrez ID		27122	8493
HPRD ID		05659	05482
Ensembl ID		ENSG00000050165	ENSG00000170836
Uniprot IDs		F6SYF8 Q9UBP4	A0A0S2Z4M2 O15297
PDB IDs
Enriched GO Terms of Interacting Partners?
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