GCG and MEP1A

Data Source:
HPRD (in vitro)

		GCG	MEP1A
Description		glucagon	meprin A subunit alpha
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Secretory Granule Lumen	Extracellular Space Integral Component Of Plasma Membrane Meprin A Complex Extracellular Exosome
	Molecular Function	Signaling Receptor Binding Hormone Activity Protein Binding Glucagon Receptor Binding Identical Protein Binding	Metalloendopeptidase Activity Protein Binding Zinc Ion Binding
	Biological Process	G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Feeding Behavior Protein Kinase A Signaling Positive Regulation Of Peptidyl-threonine Phosphorylation Response To Activity Positive Regulation Of Protein Binding Positive Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Glucose Homeostasis Negative Regulation Of Apoptotic Process Positive Regulation Of Gluconeogenesis Positive Regulation Of Protein Kinase Activity Regulation Of Insulin Secretion Positive Regulation Of Histone H3-K4 Methylation Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Glucagon Stimulus Positive Regulation Of Calcium Ion Import Negative Regulation Of Execution Phase Of Apoptosis	Proteolysis
Pathways		Glucagon signaling in metabolic regulation Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) G alpha (q) signalling events G alpha (s) signalling events Glucagon-type ligand receptors Synthesis, secretion, and deacylation of Ghrelin ADORA2B mediated anti-inflammatory cytokines production
Drugs
Diseases
GWAS		Regular attendance at a pub or social club ( 29970889)
Interacting Genes		7 interacting genes: CPE CTSL GCGR GLP1R GLP2R MEP1A MEP1B	18 interacting genes: AGT CCK FN1 GCG GNRH1 GRP KNG1 LAMA1 LAMA5 MEP1B NPY NTS PLG POMC PTH SCT TAC1 VIP
Entrez ID		2641	4224
HPRD ID		00676	02666
Ensembl ID		ENSG00000115263	ENSG00000112818
Uniprot IDs		P01275	B7ZL91 Q16819
PDB IDs		1BH0 1D0R 1NAU 2G49 2L63 2L64 2M5P 2M5Q 3IOL 4APD 4ZGM 5OTU 5OTV 5OTW 5OTX 5VAI 5YQZ 6EDS 6LMK 6LML 6NZN 6PHI 6PHJ 6PHK 6PHL 6PHO 6PHP 6VCB 6X18
Enriched GO Terms of Interacting Partners?
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