GCG and GLP2R

Data Source:
HPRD (in vitro, in vivo)

		GCG	GLP2R
Description		glucagon	glucagon like peptide 2 receptor
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Secretory Granule Lumen	Plasma Membrane Integral Component Of Membrane
	Molecular Function	Signaling Receptor Binding Hormone Activity Protein Binding Glucagon Receptor Binding Identical Protein Binding	G Protein-coupled Receptor Activity Glucagon Receptor Activity G Protein-coupled Peptide Receptor Activity Peptide Hormone Binding
	Biological Process	G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Feeding Behavior Protein Kinase A Signaling Positive Regulation Of Peptidyl-threonine Phosphorylation Response To Activity Positive Regulation Of Protein Binding Positive Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Glucose Homeostasis Negative Regulation Of Apoptotic Process Positive Regulation Of Gluconeogenesis Positive Regulation Of Protein Kinase Activity Regulation Of Insulin Secretion Positive Regulation Of Histone H3-K4 Methylation Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Glucagon Stimulus Positive Regulation Of Calcium Ion Import Negative Regulation Of Execution Phase Of Apoptosis	Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cell Population Proliferation Cellular Response To Glucagon Stimulus
Pathways		Glucagon signaling in metabolic regulation Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) G alpha (q) signalling events G alpha (s) signalling events Glucagon-type ligand receptors Synthesis, secretion, and deacylation of Ghrelin ADORA2B mediated anti-inflammatory cytokines production	G alpha (s) signalling events Glucagon-type ligand receptors ADORA2B mediated anti-inflammatory cytokines production
Drugs			Glucagon Teduglutide
Diseases
GWAS		Regular attendance at a pub or social club ( 29970889)	GIP levels in response to oral glucose tolerance test (fasting) ( 29093273) Type 2 diabetes ( 28566273 30297969)
Interacting Genes		7 interacting genes: CPE CTSL GCGR GLP1R GLP2R MEP1A MEP1B	3 interacting genes: CALM1 GCG TRIM54
Entrez ID		2641	9340
HPRD ID		00676	04713
Ensembl ID		ENSG00000115263	ENSG00000065325
Uniprot IDs		P01275	A0A384MTS7 B2RAN4 O95838
PDB IDs		1BH0 1D0R 1NAU 2G49 2L63 2L64 2M5P 2M5Q 3IOL 4APD 4ZGM 5OTU 5OTV 5OTW 5OTX 5VAI 5YQZ 6EDS 6LMK 6LML 6NZN 6PHI 6PHJ 6PHK 6PHL 6PHO 6PHP 6VCB 6X18
Enriched GO Terms of Interacting Partners?
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