VAPA and ZBTB22

Data Source:
BioGRID (two hybrid, two hybrid)

		VAPA	ZBTB22
Description		VAMP associated protein A	zinc finger and BTB domain containing 22
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Bicellular Tight Junction Integral Component Of Membrane Nuclear Membrane Vesicle Azurophil Granule Membrane Perinuclear Region Of Cytoplasm Endoplasmic Reticulum Exit Site	Chromatin Nucleus
	Molecular Function	Protein Binding Microtubule Binding Protein Domain Specific Binding FFAT Motif Binding Cadherin Binding Protein Heterodimerization Activity	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Endoplasmic Reticulum Organization Cell Death Viral Process Sphingolipid Biosynthetic Process Neuron Projection Development Protein Folding In Endoplasmic Reticulum Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Neutrophil Degranulation Positive Regulation By Host Of Viral Release From Host Cell Negative Regulation By Host Of Viral Genome Replication Positive Regulation By Host Of Viral Genome Replication Membrane Fusion Protein Localization To Endoplasmic Reticulum COPII-coated Vesicle Budding	Regulation Of Transcription By RNA Polymerase II
Pathways		Sphingolipid de novo biosynthesis Neutrophil degranulation Insertion of tail-anchored proteins into the endoplasmic reticulum membrane Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
Drugs
Diseases
GWAS		Diverticular disease ( 30177863) FEV1 ( 30804560) Heel bone mineral density ( 30598549) Lung function (FEV1/FVC) ( 30804560) Metabolite levels ( 23823483) Peak expiratory flow ( 30804560) Pulmonary function (smoking interaction) ( 23284291)	Autism spectrum disorder or schizophrenia ( 28540026)
Interacting Genes		39 interacting genes: ADGRG7 ADRB2 APOD APP AQP6 CACNG1 CD79A CYB561 CYBRD1 EBAG9 EBP EGFR ERBB2 GKN1 HSD17B11 HSD17B13 JAGN1 KCNB1 LEPROTL1 NSF OPRM1 OSBP PGRMC2 RETREG3 RMDN2 SCN3B SEC11C SIK1 SLC16A7 SLC35B1 TMEM229B TMEM35A TMEM86B TMIE TMX2 USP20 VAMP1 VAMP2 ZBTB22	16 interacting genes: AP4M1 CCDC13 DNAJA3 FXR2 GABARAPL1 GAS8 GATA1 MCRS1 MEMO1 MLLT6 PIN1 RBM39 TCEA2 UBQLN4 VAPA VAPB
Entrez ID		9218	9278
HPRD ID		09299	15761
Ensembl ID		ENSG00000101558	ENSG00000236104
Uniprot IDs		Q9P0L0	A0A1U9X8V3 O15209
PDB IDs		2RR3
Enriched GO Terms of Interacting Partners?
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