VAPA and OSBP

Data Source:
HPRD (in vivo, two hybrid, in vitro)

		VAPA	OSBP
Description		VAMP associated protein A	oxysterol binding protein
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GO Annotations	Cellular Component	Golgi Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Bicellular Tight Junction Integral Component Of Membrane Nuclear Membrane Vesicle Azurophil Granule Membrane Perinuclear Region Of Cytoplasm Endoplasmic Reticulum Exit Site	Golgi Membrane Nucleoplasm Nucleolus Cytoplasm Endoplasmic Reticulum Membrane Golgi Apparatus Trans-Golgi Network Cytosol Plasma Membrane Membrane Cell Junction Intracellular Membrane-bounded Organelle Perinuclear Region Of Cytoplasm Perinuclear Endoplasmic Reticulum
	Molecular Function	Protein Binding Microtubule Binding Protein Domain Specific Binding FFAT Motif Binding Cadherin Binding Protein Heterodimerization Activity	Protein Binding Oxysterol Binding Sterol Transporter Activity Protein Domain Specific Binding Sterol Binding Phosphatidylinositol-4-phosphate Binding Sterol Transfer Activity
	Biological Process	Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Endoplasmic Reticulum Organization Cell Death Viral Process Sphingolipid Biosynthetic Process Neuron Projection Development Protein Folding In Endoplasmic Reticulum Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Neutrophil Degranulation Positive Regulation By Host Of Viral Release From Host Cell Negative Regulation By Host Of Viral Genome Replication Positive Regulation By Host Of Viral Genome Replication Membrane Fusion Protein Localization To Endoplasmic Reticulum COPII-coated Vesicle Budding	Bile Acid Biosynthetic Process Sterol Transport Intracellular Cholesterol Transport Intermembrane Lipid Transfer
Pathways		Sphingolipid de novo biosynthesis Neutrophil degranulation Insertion of tail-anchored proteins into the endoplasmic reticulum membrane Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	Sphingolipid de novo biosynthesis Synthesis of bile acids and bile salts
Drugs
Diseases
GWAS		Diverticular disease ( 30177863) FEV1 ( 30804560) Heel bone mineral density ( 30598549) Lung function (FEV1/FVC) ( 30804560) Metabolite levels ( 23823483) Peak expiratory flow ( 30804560) Pulmonary function (smoking interaction) ( 23284291)
Interacting Genes		39 interacting genes: ADGRG7 ADRB2 APOD APP AQP6 CACNG1 CD79A CYB561 CYBRD1 EBAG9 EBP EGFR ERBB2 GKN1 HSD17B11 HSD17B13 JAGN1 KCNB1 LEPROTL1 NSF OPRM1 OSBP PGRMC2 RETREG3 RMDN2 SCN3B SEC11C SIK1 SLC16A7 SLC35B1 TMEM229B TMEM35A TMEM86B TMIE TMX2 USP20 VAMP1 VAMP2 ZBTB22	2 interacting genes: CSNK2A1 VAPA
Entrez ID		9218	5007
HPRD ID		09299	01327
Ensembl ID		ENSG00000101558	ENSG00000110048
Uniprot IDs		Q9P0L0	P22059
PDB IDs		2RR3	2RR3
Enriched GO Terms of Interacting Partners?
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