SYK and TRIM15

Data Source:
BioGRID (protein complementation assay)

		SYK	TRIM15
Description		spleen associated tyrosine kinase	tripartite motif containing 15
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Plasma Membrane B Cell Receptor Complex Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Early Phagosome Protein-containing Complex T Cell Receptor Complex	Cytoplasm
	Molecular Function	Phosphotyrosine Residue Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Signaling Receptor Binding Integrin Binding Protein Binding ATP Binding Interleukin-15 Receptor Binding Protein Kinase Binding Phosphatase Binding Toll-like Receptor Binding SH2 Domain Binding	Transcription Coactivator Activity Protein Binding Zinc Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Angiogenesis Lymph Vessel Development Positive Regulation Of Receptor Internalization Stimulatory C-type Lectin Receptor Signaling Pathway Adaptive Immune Response Macrophage Activation Involved In Immune Response Neutrophil Activation Involved In Immune Response Leukocyte Activation Involved In Immune Response Serotonin Secretion By Platelet Protein Phosphorylation Protein Import Into Nucleus Leukocyte Cell-cell Adhesion Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Integrin-mediated Signaling Pathway Activation Of JUN Kinase Activity Animal Organ Morphogenesis Regulation Of Platelet Activation Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Viral Process Peptidyl-serine Phosphorylation Peptidyl-tyrosine Phosphorylation Leukotriene Biosynthetic Process Cell Differentiation Platelet Activation Neutrophil Chemotaxis Positive Regulation Of Protein-containing Complex Assembly Receptor Internalization Positive Regulation Of Type I Interferon Production Positive Regulation Of Granulocyte Macrophage Colony-stimulating Factor Production Positive Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-3 Production Positive Regulation Of Interleukin-4 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Tumor Necrosis Factor Production Regulation Of Superoxide Anion Generation Positive Regulation Of Superoxide Anion Generation Positive Regulation Of Cell Adhesion Mediated By Integrin Collagen-activated Tyrosine Kinase Receptor Signaling Pathway Fc-epsilon Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Interleukin-2-mediated Signaling Pathway Interleukin-3-mediated Signaling Pathway Defense Response To Bacterium Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Mast Cell Degranulation Regulation Of Neutrophil Degranulation Beta Selection Innate Immune Response Positive Regulation Of B Cell Differentiation Positive Regulation Of Gamma-delta T Cell Differentiation Positive Regulation Of Bone Resorption Positive Regulation Of Alpha-beta T Cell Differentiation Positive Regulation Of Alpha-beta T Cell Proliferation Blood Vessel Morphogenesis Positive Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Phagocytosis Positive Regulation Of Calcium-mediated Signaling B Cell Receptor Signaling Pathway Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Killing Of Cells Of Other Organism Regulation Of ERK1 And ERK2 Cascade Cellular Response To Molecule Of Fungal Origin Cellular Response To Low-density Lipoprotein Particle Stimulus Positive Regulation Of Monocyte Chemotactic Protein-1 Production Regulation Of Arachidonic Acid Secretion Regulation Of Platelet Aggregation Positive Regulation Of Cold-induced Thermogenesis	Mesodermal Cell Fate Determination Regulation Of Gene Expression Protein Ubiquitination Positive Regulation Of Type I Interferon Production Innate Immune Response Positive Regulation Of Transcription, DNA-templated Positive Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of RIG-I Signaling Pathway Negative Regulation Of Intracellular Transport Of Viral Material Negative Regulation Of Viral Release From Host Cell
Pathways		GPVI-mediated activation cascade GPVI-mediated activation cascade FCGR activation FCGR activation Regulation of actin dynamics for phagocytic cup formation Role of phospholipids in phagocytosis DAP12 signaling Fc epsilon receptor (FCERI) signaling Fc epsilon receptor (FCERI) signaling Role of LAT2/NTAL/LAB on calcium mobilization Role of LAT2/NTAL/LAB on calcium mobilization FCERI mediated MAPK activation FCERI mediated Ca+2 mobilization FCERI mediated Ca+2 mobilization Integrin signaling CLEC7A (Dectin-1) signaling Dectin-2 family Dectin-2 family Interleukin-2 signaling Regulation of signaling by CBL Regulation of signaling by CBL FCGR3A-mediated IL10 synthesis FCGR3A-mediated phagocytosis FLT3 signaling through SRC family kinases Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Drugs		Staurosporine N-(2-hydroxy-1,1-dimethylethyl)-1-methyl-3-(1H-pyrrolo[2,3-b]pyridin-2-yl)-1H-indole-5-carboxamide Tamatinib 2-{2-[(3,5-dimethylphenyl)amino]pyrimidin-4-yl}-N-[(1S)-2-hydroxy-1-methylethyl]-4-methyl-1,3-thiazole-5-carboxamide 2-{[(1R,2S)-2-aminocyclohexyl]amino}-4-[(3-methylphenyl)amino]pyrimidine-5-carboxamide Ellagic acid Fostamatinib
Diseases
GWAS		Alzheimer's disease ( 30636644) Anti-saccade response ( 29064472) Atrial fibrillation ( 28416822) Chromosomal aberration frequency (total) ( 31586183) Frontal pole volume ( 31530798) Mean platelet volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Metabolite levels ( 23823483) Multiple sclerosis ( 21833088) Multiple sclerosis and HDL levels (pleiotropy) ( 26920376) Platelet count ( 32888494) Platelet distribution width ( 32888494 27863252) Plateletcrit ( 32888494) Type 2 diabetes ( 22456796) Vascular dementia ( 23480133)	Anger ( 24489884) Asthma (adult onset) ( 31036433) Asthma (childhood onset) ( 31036433) Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 28240269) Hemoglobin ( 32888494) Mean corpuscular hemoglobin ( 32888494) Neurociticism ( 29500382) Neuroticism ( 29255261) Red cell distribution width ( 32888494)
Interacting Genes		107 interacting genes: APP AR BLNK BTK CALM1 CBL CBLB CD19 CD22 CD3E CD72 CD79A CD79B COASY CRKL CSF2RB CSF3R CTTN DBNL DPP9 DUSP3 EGFR EPOR ERBB2 ERBB3 ERBB4 FCER1G FCGR1A FCGR2A FCGR3A FCRL3 FGR FYN GAB1 GAB2 GRB2 HCLS1 HDAC1 HDAC2 HDAC3 HDAC4 HDAC6 HDAC9 HGS HNRNPU IL15RA IL2RB ITGB2 JAK1 KIT LAT LAX1 LCK LCP2 LYN MAP4K1 MAPK3 MAPT MET MS4A2 NEDD4 NFAM1 PAG1 PIK3AP1 PIK3R1 PIK3R2 PLCG1 PLCG2 POU2AF1 PRKCA PRKD1 PTK2 PTK2B PTPN6 PXN RASA1 RHOU RPS10 RPS6KA1 RPS6KB1 RPS6KB2 SELPLG SH2B2 SH2D2A SH3BP2 SHC1 SIT1 SLA SLC4A1 SNCA SRC STAT1 STAT3 STAT5A TERF1 TLR4 TNFRSF1A TRAF6 TRIM15 TUBA1A TUBA4A TYROBP UBASH3B UBB USP25 VAV1 VAV2	39 interacting genes: ACD ACTB AXIN1 CDK6 CFL1 CORO1B CTTN EHMT1 FAM151B FAM161A FAM161B FBLIM1 FERMT2 FERMT3 GAB1 GTF2E1 IRF5 KEAP1 MED7 MSN MYBL2 NEXN PFN1 PRNP PTK2 PXN RABGEF1 ROCK1 SHC1 SNW1 SYK TAF9B TINF2 TRIM8 UBE2U VASP VCL VIM YJU2
Entrez ID		6850	89870
HPRD ID		02514	15551
Ensembl ID		ENSG00000165025	ENSG00000204610
Uniprot IDs		A0A024R244 A0A024R273 P43405	Q5SRL0 Q9C019
PDB IDs		1A81 1CSY 1CSZ 1XBA 1XBB 1XBC 3BUW 3EMG 3FQE 3FQH 3FQS 3SRV 3TUB 3TUC 3TUD 3VF8 3VF9 4DFL 4DFN 4F4P 4FL1 4FL2 4FL3 4FYN 4FYO 4FZ6 4FZ7 4GFG 4I0R 4I0S 4I0T 4PUZ 4PV0 4PX6 4RSS 4RX7 4RX8 4RX9 4WNM 4XG2 4XG3 4XG4 4XG6 4XG7 4XG8 4XG9 4YJO 4YJP 4YJQ 4YJR 4YJS 4YJT 4YJU 4YJV 5C26 5C27 5CXH 5CXZ 5CY3 5GHV 5LMA 5LMB 5T68 5TIU 5TR6 5TT7 5Y5T 5Y5U 6HM6 6HM7 6SSB 6VOV
Enriched GO Terms of Interacting Partners?
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