PAK2 and RAC1

Data Source:
BioGRID (two hybrid, pull down)
HPRD (in vitro)

		PAK2	RAC1
Description		p21 (RAC1) activated kinase 2	Rac family small GTPase 1
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Plasma Membrane Cell-cell Junction Postsynaptic Density Perinuclear Region Of Cytoplasm Glutamatergic Synapse	Golgi Membrane Cytoplasm Endoplasmic Reticulum Membrane Trans-Golgi Network Cytosol Cytoskeleton Actin Filament Plasma Membrane Focal Adhesion Cell Cortex Membrane Lamellipodium Secretory Granule Membrane Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Cytoplasmic Vesicle Ruffle Membrane Cytoplasmic Ribonucleoprotein Granule Melanosome Cell Projection Dendritic Spine Intracellular Membrane-bounded Organelle Recycling Endosome Membrane Extracellular Exosome Postsynapse Glutamatergic Synapse Ficolin-1-rich Granule Membrane
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Protein Kinase Binding Protein Tyrosine Kinase Activator Activity Small GTPase Binding Identical Protein Binding Cadherin Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity	GTPase Activity Protein Binding GTP Binding Enzyme Binding Protein Kinase Binding Thioesterase Binding Histone Deacetylase Binding Protein-containing Complex Binding Rho GDP-dissociation Inhibitor Binding ATPase Binding
	Biological Process	Stimulatory C-type Lectin Receptor Signaling Pathway Protein Phosphorylation Negative Regulation Of Protein Kinase Activity Apoptotic Process Phosphorylation Peptidyl-serine Phosphorylation Stress-activated Protein Kinase Signaling Cascade T Cell Costimulation Activation Of Protein Kinase Activity Adherens Junction Assembly Interleukin-12-mediated Signaling Pathway Fc-epsilon Receptor Signaling Pathway Regulation Of Growth Negative Regulation Of Apoptotic Process Protein Autophosphorylation Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Defense Response To Virus By Virus Positive Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Axonogenesis T Cell Receptor Signaling Pathway Regulation Of Cytoskeleton Organization Negative Regulation Of Stress Fiber Assembly Dendritic Spine Development Positive Regulation Of Protein Tyrosine Kinase Activity Bicellular Tight Junction Assembly Cellular Response To Organic Cyclic Compound Protein Localization To Cell-cell Junction Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Execution Phase Of Apoptosis	Neuron Migration Positive Regulation Of Protein Phosphorylation Mast Cell Chemotaxis Sphingosine-1-phosphate Receptor Signaling Pathway Inflammatory Response Actin Filament Organization Cell Adhesion Cell-matrix Adhesion Establishment Or Maintenance Of Cell Polarity Blood Coagulation Motor Neuron Axon Guidance Cell Population Proliferation Regulation Of Cell Shape Regulation Of Cell Size Response To Wounding Anatomical Structure Morphogenesis Regulation Of Hydrogen Peroxide Metabolic Process Regulation Of Lamellipodium Assembly Positive Regulation Of Lamellipodium Assembly Positive Regulation Of Endothelial Cell Migration Negative Regulation Of Fibroblast Migration Positive Regulation Of Cell-substrate Adhesion Rac Protein Signal Transduction Cell Projection Assembly Lamellipodium Assembly Actin Cytoskeleton Organization Actin Filament Polymerization Regulation Of Cell Migration Cortical Cytoskeleton Organization Positive Regulation Of Microtubule Polymerization T Cell Costimulation Ruffle Organization Negative Regulation Of Interleukin-23 Production Regulation Of Actin Cytoskeleton Organization Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Rho Protein Signal Transduction Intracellular Signal Transduction Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Fc-epsilon Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Neutrophil Degranulation Engulfment Of Apoptotic Cell Regulation Of Nitric Oxide Biosynthetic Process Bone Resorption Positive Regulation Of DNA Replication Vascular Endothelial Growth Factor Receptor Signaling Pathway Hepatocyte Growth Factor Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Negative Regulation Of Receptor-mediated Endocytosis Cell Motility Regulation Of Defense Response To Virus By Virus Regulation Of Small GTPase Mediated Signal Transduction Regulation Of Stress Fiber Assembly Positive Regulation Of Stress Fiber Assembly Localization Within Membrane Positive Regulation Of Focal Adhesion Assembly Positive Regulation Of Protein Kinase B Signaling Wnt Signaling Pathway, Planar Cell Polarity Pathway Regulation Of Respiratory Burst Cellular Response To Mechanical Stimulus Semaphorin-plexin Signaling Pathway Positive Regulation Of Neutrophil Chemotaxis Ruffle Assembly Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Regulation Of Neutrophil Migration
Pathways		Nef and signal transduction Generation of second messenger molecules Regulation of PAK-2p34 activity by PS-GAP/RHG10 Regulation of activated PAK-2p34 by proteasome mediated degradation Stimulation of the cell death response by PAK-2p34 FCERI mediated MAPK activation FCERI mediated MAPK activation CD28 dependent Vav1 pathway Ephrin signaling Sema3A PAK dependent Axon repulsion Activation of RAC1 VEGFA-VEGFR2 Pathway Smooth Muscle Contraction VEGFR2 mediated vascular permeability CD209 (DC-SIGN) signaling RHO GTPases activate PAKs RHO GTPases activate PAKs MAPK6/MAPK4 signaling Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	GPVI-mediated activation cascade PIP3 activates AKT signaling Signaling by SCF-KIT Translocation of SLC2A4 (GLUT4) to the plasma membrane Nef and signal transduction NRAGE signals death through JNK Rho GTPase cycle Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation Constitutive Signaling by Aberrant PI3K in Cancer DAP12 signaling FCERI mediated MAPK activation DSCAM interactions CD28 dependent Vav1 pathway EPHB-mediated forward signaling Ephrin signaling EPH-ephrin mediated repulsion of cells Sema3A PAK dependent Axon repulsion SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion PCP/CE pathway Sema4D mediated inhibition of cell attachment and migration DCC mediated attractive signaling DCC mediated attractive signaling Activation of RAC1 Inactivation of CDC42 and RAC1 VEGFA-VEGFR2 Pathway Signal transduction by L1 VEGFR2 mediated vascular permeability RHO GTPases activate PKNs RHO GTPases activate CIT RHO GTPases activate CIT RHO GTPases activate KTN1 RHO GTPases activate IQGAPs RHO GTPases activate PAKs RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate Formins RHO GTPases Activate Formins RHO GTPases Activate NADPH Oxidases MAPK6/MAPK4 signaling Neutrophil degranulation PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases MET activates RAP1 and RAC1 NTRK2 activates RAC1 Activated NTRK2 signals through CDK5 Activation of RAC1 downstream of NMDARs FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis WNT5:FZD7-mediated leishmania damping Factors involved in megakaryocyte development and platelet production
Drugs		Fostamatinib	Dextromethorphan Azathioprine Guanosine-5'-Diphosphate
Diseases
GWAS		Asthma ( 31959851) Atrial fibrillation ( 29892015) Eosinophil counts ( 32888494 27863252) Glucose homeostasis traits ( 25524916) Lymphocyte counts ( 32888494 27863252) Malaria ( 31844061) Mean corpuscular hemoglobin concentration ( 32888494) Mean spheric corpuscular volume ( 32888494) Monocyte count ( 32888494 27863252) Neutrophil count ( 32888494) Platelet count ( 32888494 27863252) Platelet distribution width ( 32888494) Plateletcrit ( 32888494 27863252) Red cell distribution width ( 32888494) Reticulocyte fraction of red cells ( 32888494) Sum eosinophil basophil counts ( 27863252) Total ventricular volume (Alzheimer's disease interaction) ( 21116278) White blood cell count ( 32888494 27863252)	Apolipoprotein A1 levels ( 32203549) Basal cell carcinoma ( 31174203) Body mass index ( 26426971) Coronary artery disease ( 29212778) Keratinocyte cancer (MTAG) ( 31174203) LDL cholesterol levels ( 32203549) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Red cell distribution width ( 27863252)
Interacting Genes		54 interacting genes: ABI1 ABI2 ABI3 ABL1 APP ARHGAP10 ARHGEF6 ARHGEF7 BRAF CASP3 CDC42 DOCK2 DST EIF4B EIF4G1 EP300 FYN GRB2 H4C6 HCK LCK LIMK1 LYN MAPK1 MAPK3 MKNK1 MYC MYL2 MYLK NCK1 NCK2 NPHP1 PACSIN3 PPM1A RAC1 RAC2 RAF1 RHOJ RIOK3 RPS6 SH3GL2 SH3KBP1 SH3PXD2A SH3RF1 SH3RF3 SNX33 SNX9 SORBS1 SORBS2 SORBS3 SRC SYN1 VIM YES1	182 interacting genes: ACTA1 ACTB AGAP1 AGAP2 AKT1 ARAP1 ARAP2 ARFIP2 ARHGAP1 ARHGAP12 ARHGAP15 ARHGAP17 ARHGAP20 ARHGAP22 ARHGAP23 ARHGAP27 ARHGAP31 ARHGAP32 ARHGAP33 ARHGAP35 ARHGAP39 ARHGAP4 ARHGAP44 ARHGAP9 ARHGDIA ARHGDIB ARHGDIG ARHGEF10 ARHGEF2 ARHGEF25 ARHGEF26 ARHGEF4 ARHGEF7 ARL2BP BAG6 BAIAP2 BCR BIRC2 BRINP1 CASP3 CASP7 CAV1 CDC23 CDC42BPG CDC42SE1 CDC42SE2 CFAP36 CHN1 CHN2 CIT COG5 CORO1C CSN2 CYBA CYBB CYFIP1 DEF6 DIAPH1 DIAPH3 DMPK DNMBP DOCK1 DOCK2 DOCK3 DOCK7 DOCK8 DVL1 DVL2 EIF2AK2 ENAH FAM13A FAM13B FGD5 FHOD1 FLNA FMN2 FMNL1 GMIP GRN HACD3 HACE1 HDAC7 HPS4 ICMT IFNGR1 IL1RAP IQGAP1 IQGAP2 KPNA4 KPNA6 KRT40 KTN1 LATS1 LRP2 LTBP3 LTBP4 LZTS2 MAGI1 MAP3K10 MAP3K11 MAP3K4 MCF2 MCF2L MCM3AP MDFI METAP2 MT-CO3 MTNR1A MYD88 MYH9 NCF2 NCK1 NCKAP1 NEDD4 NME1 NOS2 NOXA1 NR2C2 OCRL OPHN1 PAK1 PAK2 PAK3 PAK5 PAK6 PARD6A PARD6B PARD6G PIAS3 PIK3R1 PIP4K2A PLD1 PLEKHG1 PLEKHG2 PLEKHG6 PLXNB1 PPP2R2B PREX1 PREX2 PRKCA PRKCD PRKCI PRKN PRMT6 PTK2 RACGAP1 RALBP1 RAP1GDS1 RASGRF1 RASGRF2 RCC2 RGL2 RPS6KB1 SET SFPQ SH3BP1 SH3RF1 SH3RF3 SNX31 SRGAP1 SRGAP3 STAT1 STAT3 STAU1 SYDE2 SYNJ2 TBC1D3F TIAM1 TLR2 TNFRSF12A TRIO TUBA4A UBC UNKL USH1C USP6 VAV1 VAV2 VAV3 VWF WAS WASF1
Entrez ID		5062	5879
HPRD ID		05428	03627
Ensembl ID		ENSG00000180370	ENSG00000136238
Uniprot IDs		A8K5M4 Q13177	A4D2P0 A4D2P1 P63000
PDB IDs		3PCS	1E96 1FOE 1G4U 1HE1 1HH4 1I4D 1I4L 1I4T 1MH1 1RYF 1RYH 2FJU 2H7V 2NZ8 2P2L 2RMK 2VRW 2WKP 2WKQ 2WKR 2YIN 3B13 3BJI 3RYT 3SBD 3SBE 3SU8 3SUA 3TH5 4GZL 4GZM 4YON 5FI0 5HZH 5N6O 5O33 5QQD 5QQE 5QQF 5QQG 5QQH 5QQI 5QQJ 5QQK 5QQL 5QQM 5QQN 5QU9 6AGP 6BC1 6TGC
Enriched GO Terms of Interacting Partners?
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