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MEOX2 and CDKN1A
Data Source:
BioGRID
(two hybrid)
MEOX2
CDKN1A
Description
mesenchyme homeobox 2
cyclin dependent kinase inhibitor 1A
Image
No pdb structure
GO Annotations
Cellular Component
Chromatin
Nucleus
Cytoplasm
Nuclear Speck
Cyclin-dependent Protein Kinase Holoenzyme Complex
Nucleus
Nucleoplasm
Nucleolus
Cytosol
Nuclear Body
Protein-containing Complex
Perinuclear Region Of Cytoplasm
PCNA-p21 Complex
Molecular Function
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA-binding Transcription Factor Activity
Protein Binding
Sequence-specific DNA Binding
Sequence-specific Double-stranded DNA Binding
Protein Kinase Inhibitor Activity
Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity
Protein Binding
Protein Kinase Binding
Cyclin-dependent Protein Kinase Activating Kinase Activity
Cyclin Binding
Ubiquitin Protein Ligase Binding
Protein-containing Complex Binding
Metal Ion Binding
Protein Sequestering Activity
Biological Process
Angiogenesis
Somite Specification
Regulation Of Transcription By RNA Polymerase II
Multicellular Organism Development
Skeletal Muscle Tissue Development
Blood Circulation
Positive Regulation Of Transcription By RNA Polymerase II
Roof Of Mouth Development
Limb Development
Somite Development
Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis
Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
G1/S Transition Of Mitotic Cell Cycle
G2/M Transition Of Mitotic Cell Cycle
Regulation Of Transcription By RNA Polymerase II
Transcription Initiation From RNA Polymerase II Promoter
Protein Import Into Nucleus
Cellular Response To DNA Damage Stimulus
DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest
DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator
Cell Cycle Arrest
Mitotic G2 DNA Damage Checkpoint
Ras Protein Signal Transduction
Heart Development
Negative Regulation Of Cell Population Proliferation
Response To Toxic Substance
Response To X-ray
Response To Organonitrogen Compound
Negative Regulation Of Gene Expression
Cytokine-mediated Signaling Pathway
Negative Regulation Of Cell Growth
Positive Regulation Of B Cell Proliferation
Animal Organ Regeneration
Cellular Response To Extracellular Stimulus
Negative Regulation Of Protein Binding
Cellular Response To Amino Acid Starvation
Cellular Response To Heat
Wound Healing
Tissue Regeneration
Negative Regulation Of Phosphorylation
Response To Drug
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator
Negative Regulation Of Apoptotic Process
Positive Regulation Of Programmed Cell Death
Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
Positive Regulation Of Protein Kinase Activity
Response To Arsenic-containing Substance
Positive Regulation Of Fibroblast Proliferation
Protein Stabilization
Response To Corticosterone
Response To Hyperoxia
Intestinal Epithelial Cell Maturation
Cellular Response To Ionizing Radiation
Cellular Response To Gamma Radiation
Cellular Response To UV-B
Mitotic Cell Cycle Arrest
Cellular Senescence
Replicative Senescence
Stress-induced Premature Senescence
Intrinsic Apoptotic Signaling Pathway
Regulation Of Cell Cycle G1/S Phase Transition
Negative Regulation Of Cyclin-dependent Protein Kinase Activity
Positive Regulation Of Cyclin-dependent Protein Kinase Activity
Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation
Negative Regulation Of Cardiac Muscle Tissue Regeneration
Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Negative Regulation Of DNA Biosynthetic Process
Positive Regulation Of Reactive Oxygen Species Metabolic Process
Pathways
SCF(Skp2)-mediated degradation of p27/p21
AKT phosphorylates targets in the cytosol
Senescence-Associated Secretory Phenotype (SASP)
DNA Damage/Telomere Stress Induced Senescence
Constitutive Signaling by AKT1 E17K in Cancer
Interleukin-4 and Interleukin-13 signaling
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest
Cyclin E associated events during G1/S transition
Cyclin D associated events in G1
p53-Dependent G1 DNA Damage Response
Cyclin A:Cdk2-associated events at S phase entry
Transcriptional activation of cell cycle inhibitor p21
The role of GTSE1 in G2/M progression after G2 checkpoint
TFAP2 (AP-2) family regulates transcription of cell cycle factors
Transcriptional regulation by RUNX2
RUNX3 regulates CDKN1A transcription
Transcriptional regulation of granulopoiesis
FOXO-mediated transcription of cell cycle genes
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)
STAT5 activation downstream of FLT3 ITD mutants
Signaling by FLT3 fusion proteins
Drugs
Arsenic trioxide
Diseases
Cervical cancer
GWAS
Adolescent idiopathic scoliosis (
31417091
)
Blood trace element (Zn levels) (
23720494
)
HDL cholesterol levels (
32203549
)
Heel bone mineral density (
30598549
28869591
)
HOMA-B (corrected for HOMA-IR) (
30369944
)
Kidney function decline traits (
25493955
)
Resting-state electroencephalogram vigilance (
29703947
)
Sweet taste preference (
32572145
)
Total intracranial volume (
31530798
)
Triglyceride levels (
32203549
)
Atrial fibrillation (
30061737
29892015
)
Colorectal cancer (
22634755
30529582
31826910
)
Colorectal cancer or advanced adenoma (
30510241
)
Coronary artery disease (
29212778
)
Electrocardiogram morphology (amplitude at temporal datapoints) (
32916098
)
Electrocardiographic conduction measures (
23463857
)
Electrocardiographic traits (
32602732
20062063
)
Glaucoma (primary open-angle) (
29891935
)
Heart failure (
31919418
)
Ischemic stroke (
29531354
)
JT interval (
29874175
)
Left ventricular fractional shortening (
28394258
)
PR interval (
32439900
)
Pulse pressure (
30224653
30578418
)
QRS complex (Cornell) (
27659466
)
QRS duration (
30679814
27577874
31251759
25035420
31217584
21076409
27659466
)
Triglyceride levels (
32203549
)
Triglycerides (
27036123
)
Interacting Genes
686 interacting genes:
-
ABI2
ACBD4
ACOT12
ACSS1
ACTN4
ADAMTS12
ADGRF4
AGPAT1
AHCYL1
AHNAK
AHSA2P
AKT2
ALOX5
ALPP
AMMECR1
AMOT
ANKRD1
ANKRD12
ANKS1A
ANP32B
AP3M2
ARF6
ARHGEF7
ARIH2
ARL15
ARNT2
ARNTL2
ASB10
ATG12
ATG2A
ATG5
ATG9A
ATP5F1C
ATP6V0D2
ATP6V1C2
ATPSCKMT
ATXN1L
AXIN1
B4GALT2
BANP
BCL2L15
BEX1
BMP5
BNIP2
BOD1L2
BOLA2
BOLA2B
BTBD3
BTK
BTN1A1
BUD31
BYSL
C10orf120
C10orf88
C11orf68
C1orf109
C1orf174
C1orf50
C2orf76
C9orf64
CACNA1S
CAMK2B
CAPRIN2
CARD9
CASP14
CBX2
CCDC102B
CCDC103
CCDC13
CCDC196
CCDC6
CCL19
CCNC
CCNYL1
CDC34
CDC7
CDCA7L
CDH9
CDK3
CDK5
CDKN1A
CDKN2D
CEP57L1
CFAP206
CHD2
CHIC2
CHRD
CHRNB4
CHRNG
CHST15
CIAO1
CIAPIN1
CIB3
CINP
CKS1B
CLIC1
CLIP4
CLP1
CLVS2
CMTM5
CNTNAP2
COG7
COL9A2
COMP
COX7A2
CPNE2
CPNE6
CPNE7
CPSF4
CRCT1
CSDC2
CSF2
CSH2
CSNK2A1
CT55
CTNNBL1
CUTC
CXCL1
CXCL5
CXorf38
CXXC1
CYB5R2
CYCS
CYP4F12
CYSRT1
DCX
DEF8
DEFA5
DEPDC5
DESI1
DGCR6
DGCR8
DHPS
DIRAS3
DMRT3
DNAAF11
DNAJC17
DNAJC22
DNMT3A
DOCK8
DPF2
DPH3
DPM1
DRG1
DSCR8
DUS1L
DYNC2I2
DYNLL2
DYNLT5
E2F8
EDF1
EFEMP1
EFEMP2
EFNA3
EIF1AD
EIF3G
EIF4A3
EIF5A
EIF6
EMC7
EMD
EME2
EPM2AIP1
ERF
ESM1
ESR2
ESRRG
ETV4
EXOSC5
FAAP20
FAM126A
FAM13C
FAM219B
FAM221A
FAM3A
FAM53B
FAM53C
FAM71E2
FAM74A4
FANCC
FANCG
FBF1
FBLN1
FBLN5
FBXO39
FBXO44
FDX2
FGA
FKBP6
FOSL2
FOXR1
FTL
FUCA2
FUT11
FYN
GABRB3
GAGE1
GCM2
GINS3
GJC1
GLO1
GMCL2
GMPR2
GNG11
GNG13
GOLGA8DP
GOLGA8EP
GOLGA8F
GPANK1
GPATCH2L
GPKOW
GPSM3
GRIPAP1
GRN
GSDMD
GTPBP3
GUCD1
H1-7
HAT1
HDAC7
HDHD2
HELLS
HEXIM2
HGF
HK3
HLA-A
HLA-DPB1
HMBOX1
HMGB3
HNRNPC
HNRNPD
HOOK1
HOOK3
HORMAD1
HOXB5
HOXC8
HP1BP3
HSD3B7
HSPA2
HTR1E
IFIT2
IFNA14
IFNA6
IGF2BP3
IGFN1
IKZF1
IL1A
ILF2
INPP1
INPP5J
INSRR
INTS10
IP6K2
IP6K3
IQGAP1
IRX6
ITGB3BP
ITM2A
JAM3
JPH1
KANK2
KAT5
KATNAL1
KBTBD7
KCNIP4
KCTD7
KCTD9
KDM6A
KDM8
KIF5B
KIF5C
KIZ
KLC4
KLHL32
KLHL38
KPRP
KRT80
KRT81
KRT83
KRT86
KRTAP10-1
KRTAP10-11
KRTAP10-3
KRTAP10-5
KRTAP10-8
KRTAP10-9
KRTAP12-1
KRTAP12-2
KRTAP12-3
KRTAP12-4
KRTAP13-2
KRTAP4-11
KRTAP4-12
KRTAP4-2
KRTAP4-4
KRTAP4-5
KRTAP4-7
KRTAP5-11
KRTAP5-2
KRTAP5-3
KRTAP5-4
KRTAP5-6
KRTAP5-9
KRTAP6-3
KRTAP9-2
KRTAP9-3
KRTAP9-8
KRTCAP3
KTN1
LAMTOR5
LARP1B
LAT
LCE1B
LCE1D
LCE1E
LCE2A
LCE4A
LCN15
LEMD1
LIN37
LIPF
LMO1
LNX1
LRRC18
LRRC27
LRRC52
LSM2
LUC7L2
LY6G6D
MAB21L2
MACO1
MAGED1
MALSU1
MAPKBP1
MAPRE1
MAPRE3
MBD3
MCM7
MDFI
METAP1
METTL17
METTL21A
MFF
MICOS10-NBL1
MID2
MKRN3
MLF1
MLLT6
MLX
MMP25
MMP3
MOAP1
MOBP
MORF4L1
MORF4L2
MORN3
MOS
MPP1
MRFAP1L1
MSI2
MT-CO1
MT-ND1
MT1DP
MTMR10
MVP
MYBPC1
MYL7
MYO5B
NAA10
NAA60
NALCN
NBL1
NCALD
NCK2
NCS1
NDUFA11
NDUFB2
NECTIN2
NEK6
NELL1
NFKBID
NFYB
NLGN3
NME7
NOL4
NOP10
NPIPB5
NR1D2
NSF
NTAN1
NTF3
NTN4
ODAD4
ODF1
ODF2
ODF2L
ODF4
OIT3
OLFM1
OLFM3
OR5K2
OR6B1
OSBPL1A
OSGIN1
OSTF1
P4HA3
PACSIN2
PAGE2
PAGE5
PAK1IP1
PAM16
PARP3
PARVG
PAX1
PAX3
PCDH9
PCSK5
PDE4C
PDHA2
PDP1
PDS5A
PELO
PGBD1
PHF1
PICK1
PIN1
PKIG
PLAC8
PLCB4
PLCD4
PMM2
PMS2
PNKP
PNLIPRP1
POLR1A
POLR1C
POLR3GL
POM121C
POMT1
PPP1CB
PPP1R18
PRAP1
PRKAB2
PRKAG1
PRKCI
PRKG1
PRKN
PRL
PRMT3
PRPF18
PRPF31
PRR19
PSMB10
PSMB8
PSMC1
PSMD14
PSMD9
PSME3
PTGER3
PWWP3A
PXT1
RAB11B
RAB2B
RAB41
RAB6B
RAD51B
RAD51D
RAD52
RAP1GAP2
RARB
RASAL2
RBM10
RBM5
RBPJL
RCHY1
RECK
RELA
RFTN2
RFX3
RGS5
RHOJ
RIMS3
RIPPLY1
RMND5A
RND2
RNF25
RNF40
RNF41
RNF6
RPL15
RPL23
RPP40
RPS4Y1
RRP8
RUNX1T1
RWDD2B
SAE1
SAMD4A
SAMM50
SAT1
SATB1
SCAF1
SCARF1
SCG5
SCIMP
SCNM1
SCRN2
SDCBP
SEC14L4
SEC63
SELENOP
SET
SFTPB
SH2D1B
SH2D4A
SHFL
SHISA3
SIRPB1
SKP1
SLC22A23
SLC23A1
SLC24A5
SLC25A17
SLC25A31
SLC27A5
SLC48A1
SLC66A1L
SLC9A8
SLIT1
SMAD3
SMARCE1
SMG6
SMYD1
SNRPF
SPANXN2
SPANXN3
SPATA1
SPEG
SPON1
SPP1
SPRED1
SPRY1
SPRY2
SPRY3
SPTY2D1
SRSF11
SSX3
STAC
STC1
STK11IP
STK16
STRA8
STX11
STX16
STX6
STXBP1
SUFU
SUSD4
SYNE2
SYT17
TAF1B
TASOR2
TBC1D21
TBCEL
TBL2
TBRG4
TBX6
TCEA2
TCEANC
TCL6
TDO2
TEX14
TEX47
TGFB1
THRA
TICAM2
TJAP1
TMEM100
TMEM14B
TMEM266
TMPRSS11E
TNPO3
TP53BP1
TPTE
TRAF5
TRAF6
TRAPPC2L
TRARG1
TRIM17
TRIM41
TRIM42
TRIM45
TRIM50
TRIML2
TRIP10
TRMT112
TRMT2A
TSGA10IP
TSPAN7
TSPO
TSR2
TSSK1B
TSTD2
TTC39B
TTC9C
TTLL10
TULP2
TXLNA
TXLNB
TXN2
TXNL4B
U2AF1
U2AF1L5
UBA2
UBE2D1
UBE2K
UBE3A
UBL4A
UBL4B
UBXN2B
UBXN8
UNC45A
UPP2
USE1
USP20
USP32
UTP14C
UTP23
UTP25
VAC14
VASN
VBP1
VCX2
VDR
VEZF1
VIP
VMP1
VPS26C
VWA5A
VWC2L
VWCE
WDR37
WDR5
WFDC13
WFDC5
WFDC6
WFDC9
XPA
XRCC2
YJU2
ZBED4
ZBED8
ZBTB16
ZBTB2
ZCWPW1
ZFP42
ZKSCAN3
ZKSCAN4
ZMAT2
ZMYND8
ZNF124
ZNF202
ZNF23
ZNF248
ZNF250
ZNF276
ZNF329
ZNF330
ZNF404
ZNF410
ZNF417
ZNF483
ZNF490
ZNF512B
ZNF556
ZNF564
ZNF572
ZNF574
ZNF587
ZNF648
ZNF688
ZNF69
ZNF695
ZNF772
ZNF92
205 interacting genes:
A1BG
A2M
ABL1
ACTB
ACTL6B
ADAMTS10
AKT1
AKT2
ALAS1
ANGPT2
APLP1
APP
ATP5F1B
ATP6V1A
ATXN3
BAD
BAG6
BCCIP
CASP3
CCDC85B
CCN3
CCNA1
CCNA2
CCNB1
CCNB2
CCND1
CCND2
CCND3
CCNE1
CCNE2
CCT7
CDC45
CDC5L
CDC6
CDC7
CDK1
CDK14
CDK2
CDK3
CDK4
CDK6
CEBPA
CELF3
CENPB
CHEK2
CHGB
CIZ1
CLEC3B
COL4A5
COPS6
CPNE2
CPNE6
CSAD
CSNK2A1
CSNK2B
CTSB
CZIB
DAPK3
DCAF11
DDAH2
DEAF1
DOCK7
DTL
DYNC1I1
EEF1A1
ESR1
EXT2
F13A1
FAF1
FBN3
FGB
FHL3
FLAD1
FNDC11
GADD45A
GADD45B
GADD45G
GAPDH
GCKR
GDF9
GET4
GMNN
GNB2
GNB5
GOLGA2
H1-5
HADHB
HDAC1
HDAC11
HDAC2
HDAC4
HDAC6
HERC5
HMGXB3
HNRNPK
HOOK2
HOXD8
HPD
IKBKG
IKZF3
INCA1
ING5
INPP5K
KIFC3
KLHL23
KMT2B
KRT31
KRTAP3-1
LATS2
LRIF1
LRP2BP
LRR1
LZTS2
MAP3K5
MAPK8
MCM10
MED31
MEOX2
MSH2
MTUS2
NFYA
NGFR
NKD2
NMRK2
NPRL2
NR1H2
NRBP1
OTUB1
PARP1
PCNA
PDE4DIP
PDHB
PIM1
PKM
POLD2
PRKACA
PRKAR1B
PRKN
PSMA3
PSMC2
QARS1
RAB1A
RACK1
RAI1
RB1
RBBP4
RBM48
REL
RNF126
RNF144B
RPL18
RPL35
RPS2
RRM2B
S100A8
SDF4
SET
SETDB1
SHISA6
SIPA1
SKP1
SKP2
SLC25A11
SP110
SPRED1
STAT3
STAT5B
STUB1
SUMO3
TAF5L
TCF4
TEX11
TFIP11
TK1
TLE1
TMSB4X
TNIP1
TNIP2
TP53
TRAF1
TRIM3
TRIM54
TRMT2A
TSG101
TTLL5
TUBA1A
TUBB2B
TUBB3
TXN
TXNDC11
UBE2D1
UNC119
USHBP1
USP11
USP4
VIM
VPS51
WDR73
WIZ
XRCC6
YWHAQ
ZBTB16
ZBTB48
ZNF135
ZNF431
Entrez ID
4223
1026
HPRD ID
02760
00298
Ensembl ID
ENSG00000106511
ENSG00000124762
Uniprot IDs
P50222
A0A024RCX5
P38936
PDB IDs
1AXC
2ZVV
2ZVW
4RJF
5E0U
6CBI
6CEJ
6CIV
6CIX
6P8H
Enriched GO Terms of Interacting Partners
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Tagcloud (Difference)
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Tagcloud (Intersection)
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