BRD1 and DISC1

Data Source:
BioGRID (two hybrid)

		BRD1	DISC1
Description		bromodomain containing 1	DISC1 scaffold protein
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GO Annotations	Cellular Component	Nucleus Chromosome Nuclear Speck Dendrite Histone H3-K14 Acetyltransferase Complex Perikaryon MOZ/MORF Histone Acetyltransferase Complex	Nucleus Mitochondrion Endoplasmic Reticulum Centrosome Cytosol Kinesin Complex Microtubule Synaptic Vesicle Postsynaptic Density Dynein Complex Ciliary Basal Body Cell Body Intermediate Filament Cytoskeleton Perinuclear Region Of Cytoplasm Central Region Of Growth Cone Ciliary Base
	Molecular Function	Protein Binding Histone Binding Histone Acetyltransferase Activity (H3-K23 Specific) Metal Ion Binding	Protein Binding Kinesin Binding Protein-containing Complex Binding Molecular Adaptor Activity
	Biological Process	Response To Immobilization Stress Erythrocyte Maturation Histone H3 Acetylation Histone H3-K23 Acetylation Histone H3-K14 Acetylation Positive Regulation Of Erythrocyte Differentiation Response To Electrical Stimulus	Microtubule Cytoskeleton Organization Neuron Migration Positive Regulation Of Cell-matrix Adhesion Positive Regulation Of Neuroblast Proliferation Regulation Of Neuron Projection Development Positive Regulation Of Neuron Projection Development Cell Proliferation In Forebrain Pyramidal Neuron Migration Positive Regulation Of Wnt Signaling Pathway TOR Signaling Negative Regulation Of Protein Binding Positive Regulation Of Axon Extension Mitochondrial Calcium Ion Homeostasis Response To Electrical Stimulus Regulation Of Synaptic Transmission, Glutamatergic Canonical Wnt Signaling Pathway Cilium Assembly Regulation Of Dendritic Spine Development Protein Localization To Centrosome Regulation Of Synapse Maturation Non-motile Cilium Assembly Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process
Pathways		HATs acetylate histones Regulation of TP53 Activity through Acetylation
Drugs
Diseases
GWAS		Acne (severe) ( 24927181) Mean platelet volume ( 27863252) Metabolite levels ( 23823483) Natriuretic peptide levels ( 21273288) Pulse pressure ( 30224653) Schizophrenia ( 23894747) Urinary albumin excretion ( 32277301) Youthful appearance (self-reported) ( 32339537)	Alzheimer's disease ( 19118814) Amyotrophic lateral sclerosis ( 19451621) Amyotrophic lateral sclerosis (sporadic) ( 24529757) Arterial stiffness index ( 31235810) Chronic periodontitis (mean interproximal clinical attachment level) ( 27601451) Metabolite levels ( 23823483) Neuranatomic and neurocognitive phenotypes ( 21483430) Pelvic organ prolapse (moderate/severe) ( 26545240) Response to antidepressants (symptom improvement) ( 29160301) Response to antineoplastic agents ( 21659360) Response to statin therapy ( 20339536) Serum docosahexaenoic fatty acid concentration in metabolic syndrome ( 31991592) Waist circumference ( 28552196)
Interacting Genes		17 interacting genes: CASP8 CEP126 CEP70 DISC1 FEZ1 FEZ2 H2AX H3C14 HMBOX1 MAGEA11 PICK1 RUBCN SS18L1 TFIP11 VIM ZNF512B ZRANB1	188 interacting genes: ABI2 ACTG1 ACTN2 ADO AGTPBP1 AIMP2 AKAP6 AMOT AP1M1 ARIH2 ARMC7 ATF4 ATF5 ATF7IP BAG2 BFSP2 BICD1 BORCS6 BRD1 C1orf109 C2CD6 C8orf33 CARD9 CCDC102B CCDC13 CCDC136 CCDC141 CCDC197 CCDC24 CCDC57 CCDC88A CCDC92 CCHCR1 CDC23 CDC37 CDC5L CDK5RAP3 CDKL3 CEP126 CEP57 CEP57L1 CEP63 CFAP206 CIT CLU COL4A1 CTNNA3 CWF19L2 DCTN1 DCTN2 DDX6 DMD DNAJC7 DPYSL2 DPYSL3 DST DYNC1H1 EEF2 EIF3H EIF4A3 EMSY EXOC1 EXOC4 EXOC7 FBXO34 FBXO41 FBXW7 FEZ1 FLACC1 FRYL GABARAPL1 GAS2L2 GAS8 GCC1 GEM GNB1 GNG13 GNPTAB GPANK1 GPRASP2 GRIPAP1 GSK3B HERC2P2 HNRNPC IFT20 IFT74 IMMT ITSN1 KALRN KANSL1 KCNQ5 KIF3A KIF3C KIF9 KIFAP3 KIFC3 LENG1 MACF1 MAP1A MEMO1 MLLT10 MNS1 MORF4L2 MPPED1 MVP MYH7 MYT1L NCK2 NDE1 NDEL1 NECAB1 NEFM NME7 NSRP1 NUP160 OLFM1 PCNT PCNX4 PDE4B PGK1 PHF1 PIBF1 PIK3R3 PKN1 POLR3C PPFIA3 PPM1E PPP4R1 PPP5C PSPC1 QARS1 RABGAP1 RAD21 RANBP9 RASSF7 RBM41 RBSN RECK RNF40 ROGDI RTRAF SH3BP5 SMARCD1 SMARCE1 SMC2 SMC3 SMC5 SMYD1 SNX6 SPARCL1 SPATC1L SPTBN4 SRGAP2 SRGAP3 STX11 STX18 SUFU SYBU SYNE1 TCAF1 TCEANC TFIP11 TIAM2 TNKS TRAF3IP1 TRAF4 TRIM29 TRIM68 TRIO TSGA10 TSPOAP1 TSR2 TTC23 TUBB TUBB2A UBASH3A UBASH3B USP2 UTRN XPNPEP1 YWHAE YWHAG YWHAQ YWHAZ ZNF124 ZNF197 ZNF365 ZNF76
Entrez ID		23774	27185
HPRD ID		06848	05553
Ensembl ID		ENSG00000100425	ENSG00000162946
Uniprot IDs		A0A024R4V5 A0A024R4W4 O95696 Q59G93	C4P094 C4P096 C4P098 C4P0A4 C4P0A5 C4P0C4 C4P0C8 C4P0D0 C4P0D1 C4P0D2 C4P0D3 Q9NRI5
PDB IDs		2KU3 2L43 2LQ6 3LYI 3RCW 4Z02 5AME 5AMF 5FG6 5GK9 5N49 5PNX 5PNY 5PNZ 5PO0 5PO1 5PO2 5PO3 5PO4 5PO5 5PO6 5PO7 5PO8 5PO9 5POA 5POB 5POC 5POD 5POE 5POF 5POG 5POH 5POI 5POJ 5POK 5POL 5POM 5PON 5POO 5POP 5POQ 5POR 5POS 5POT 5POU 5POV 5POW 5POX 5POY 5POZ 5PP0 5PP1 5PP2 5PP3 5PP4 5PP5 5PP6 5PP7 5PP8 5PP9 5PPA 5PPB 5PPC 5PPD 5PPE 5PPF 5PPG 5PPH 5PPI 5PPJ 5PPK 5PPL 5PPM 5PPN 5PPO 5PPP 5PPQ 5PPR 5PPS 5PPT 5PPU 5PPV 5PPW 5PPX 5PPY 5PPZ 5PQ0 5PQ1 5PQ2 5PQ3 5PQ4 5PQ5 5PQ6 5PQ7 5PQ8 5PQ9 5PQA 5PQB 5PQC 5PQD 5PQE 5PQF 5PQG 5PQH 5PQI 5PQJ 5PQK 5PQL 5PQM 5PQN 5PQO 5PQP 5PQQ 5PQR 5PQS 5PQT 5PQU 5PQV 5PQW 5PQX 5PQY 5PQZ 5PR0 5PR1 5PR2 5PR4 5PR5 5PR6 5PR7 5PR8 5PR9 5PRA 5PRB 5PRD 5PRE 5PRF 5PRG 5PRH 5PRI 5PRJ 5PRK 5PRL 5PRM 5PRO 5PRP 5PRQ 5PRR 5PRS 5PRT 5PRU 5PRV 5PRW 5PRX 5PRY 5PRZ 5PS0 5PS1 5PS2 5PS3 5PS4 5PS5 5PS6 5PS7 5PS8 5PS9 5PSA 5PSB 5PSC 5PSD 5PSE 5PSF 5PSG 5PSH 5PSI 5PSJ 5PSK 5PSL 5PSM 5PSN 5PSO 5PSP 5PSQ 5PSR 5PSS 5PST 5PSU 5PSV 5PSW 5PSX 5PSY 5PSZ 5PT0 5PT1 5PT2 5PT3 5PT4 5PT5 5PT6 5PT7 5PT8 5PT9 5PTA 5PTB 5PTC 5PTE 5PTF 5PTG 5PTH 5PTJ 5PTK 5PTL 5PTM 5PTN 5PTO 5PTQ 5PTR 5PTS 5PTT 5PTU 5PTV 5PTW 5PTX 5PTY 5PTZ 5PU0 5PU1 5PU2 5PU3 5PU4 5PU5 5PU6 5PU7 5PU8 5PU9 5PUA 5PUB 5PUC 5PUD 5PUE 5PUF 5PUG 5PUH 5PUI 5PUJ 5PUK 5PUL 5PUM 5PUN 5PUO 5PUP 5PUQ 5PUR 5PUS 5PUT 5PUU 5PUV 5PUW 5PUX 5PUY 5PUZ 5PV0 5PV1 5PV2 5PV3 5PV4 5PV5 5PV6 5PV7 5PV8 5PV9 5PVA 5PVB 5PVC 5PVD 5PVE 5PVF 5PVG 5PVH 5PVI 5PVJ 5PVK 5PVL 5PVM 5PVN 5PVO 5PVP 5PVQ 5PVR 5PVS 5PVT 5PVU 5PVV 5PVW 5PVX 5PVY 5PVZ 5PW0 5PW1 5PW2 5PW3 5PW4 5PW5 5PW6 5PW7 5PW8 5PW9 5PWA 5PWB 6IN2 6MAJ 6MAK	5V4B
Enriched GO Terms of Interacting Partners?
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