BRD1 and H2AX

Data Source:
BioGRID (pull down)

		BRD1	H2AX
Description		bromodomain containing 1	H2A.X variant histone
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GO Annotations	Cellular Component	Nucleus Chromosome Nuclear Speck Dendrite Histone H3-K14 Acetyltransferase Complex Perikaryon MOZ/MORF Histone Acetyltransferase Complex	Chromosome, Telomeric Region Nucleosome Condensed Nuclear Chromosome Male Germ Cell Nucleus XY Body Nucleus Nucleoplasm Replication Fork Centrosome Nuclear Speck Site Of Double-strand Break Extracellular Exosome Site Of DNA Damage
	Molecular Function	Protein Binding Histone Binding Histone Acetyltransferase Activity (H3-K23 Specific) Metal Ion Binding	DNA Binding Damaged DNA Binding Protein Binding Enzyme Binding Histone Binding Protein Heterodimerization Activity
	Biological Process	Response To Immobilization Stress Erythrocyte Maturation Histone H3 Acetylation Histone H3-K23 Acetylation Histone H3-K14 Acetylation Positive Regulation Of Erythrocyte Differentiation Response To Electrical Stimulus	DNA Damage Checkpoint Double-strand Break Repair Via Homologous Recombination Double-strand Break Repair Double-strand Break Repair Via Nonhomologous End Joining Nucleosome Assembly Chromatin Silencing Cellular Response To DNA Damage Stimulus Spermatogenesis Response To Ionizing Radiation Viral Process Cerebral Cortex Development Positive Regulation Of DNA Repair Meiotic Cell Cycle Cellular Response To Gamma Radiation Cellular Senescence
Pathways		HATs acetylate histones Regulation of TP53 Activity through Acetylation	Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Recognition and association of DNA glycosylase with site containing an affected purine Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Cleavage of the damaged purine Meiotic synapsis Packaging Of Telomere Ends Pre-NOTCH Transcription and Translation Formation of the beta-catenin:TCF transactivating complex Formation of the beta-catenin:TCF transactivating complex PRC2 methylates histones and DNA Condensation of Prophase Chromosomes Oxidative Stress Induced Senescence Senescence-Associated Secretory Phenotype (SASP) DNA Damage/Telomere Stress Induced Senescence RMTs methylate histone arginines SIRT1 negatively regulates rRNA expression ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression NoRC negatively regulates rRNA expression NoRC negatively regulates rRNA expression B-WICH complex positively regulates rRNA expression DNA methylation Transcriptional regulation by small RNAs Activation of anterior HOX genes in hindbrain development during early embryogenesis Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends Deposition of new CENPA-containing nucleosomes at the centromere G2/M DNA damage checkpoint RNA Polymerase I Promoter Opening RNA Polymerase I Promoter Escape RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function RUNX1 regulates transcription of genes involved in differentiation of HSCs Estrogen-dependent gene expression Meiotic recombination Transcriptional regulation of granulopoiesis Inhibition of DNA recombination at telomere Amyloid fiber formation
Drugs
Diseases
GWAS		Acne (severe) ( 24927181) Mean platelet volume ( 27863252) Metabolite levels ( 23823483) Natriuretic peptide levels ( 21273288) Pulse pressure ( 30224653) Schizophrenia ( 23894747) Urinary albumin excretion ( 32277301) Youthful appearance (self-reported) ( 32339537)
Interacting Genes		17 interacting genes: CASP8 CEP126 CEP70 DISC1 FEZ1 FEZ2 H2AX H3C14 HMBOX1 MAGEA11 PICK1 RUBCN SS18L1 TFIP11 VIM ZNF512B ZRANB1	46 interacting genes: A2M ACTB ALG9 ATM ATR BARD1 BMI1 BRCA1 BRCA2 BRD1 CALM1 COPG1 DDX21 DHX9 EYA1 HUWE1 KAT5 MASP1 MDC1 MRE11 NBN NCL NGFR OTUB1 PAXIP1 PBK PPP1CA PRKDC PTPA QARS1 RNF168 RNF8 RPS6KA3 SMARCA4 SSRP1 SUPT16H SUPT5H TAF1C TAF5L TERF2 TIAM2 TOPORS TP53BP1 TRAF6 TSSK6 WRN
Entrez ID		23774	3014
HPRD ID		06848	03465
Ensembl ID		ENSG00000100425	ENSG00000188486
Uniprot IDs		A0A024R4V5 A0A024R4W4 O95696 Q59G93	P16104
PDB IDs		2KU3 2L43 2LQ6 3LYI 3RCW 4Z02 5AME 5AMF 5FG6 5GK9 5N49 5PNX 5PNY 5PNZ 5PO0 5PO1 5PO2 5PO3 5PO4 5PO5 5PO6 5PO7 5PO8 5PO9 5POA 5POB 5POC 5POD 5POE 5POF 5POG 5POH 5POI 5POJ 5POK 5POL 5POM 5PON 5POO 5POP 5POQ 5POR 5POS 5POT 5POU 5POV 5POW 5POX 5POY 5POZ 5PP0 5PP1 5PP2 5PP3 5PP4 5PP5 5PP6 5PP7 5PP8 5PP9 5PPA 5PPB 5PPC 5PPD 5PPE 5PPF 5PPG 5PPH 5PPI 5PPJ 5PPK 5PPL 5PPM 5PPN 5PPO 5PPP 5PPQ 5PPR 5PPS 5PPT 5PPU 5PPV 5PPW 5PPX 5PPY 5PPZ 5PQ0 5PQ1 5PQ2 5PQ3 5PQ4 5PQ5 5PQ6 5PQ7 5PQ8 5PQ9 5PQA 5PQB 5PQC 5PQD 5PQE 5PQF 5PQG 5PQH 5PQI 5PQJ 5PQK 5PQL 5PQM 5PQN 5PQO 5PQP 5PQQ 5PQR 5PQS 5PQT 5PQU 5PQV 5PQW 5PQX 5PQY 5PQZ 5PR0 5PR1 5PR2 5PR4 5PR5 5PR6 5PR7 5PR8 5PR9 5PRA 5PRB 5PRD 5PRE 5PRF 5PRG 5PRH 5PRI 5PRJ 5PRK 5PRL 5PRM 5PRO 5PRP 5PRQ 5PRR 5PRS 5PRT 5PRU 5PRV 5PRW 5PRX 5PRY 5PRZ 5PS0 5PS1 5PS2 5PS3 5PS4 5PS5 5PS6 5PS7 5PS8 5PS9 5PSA 5PSB 5PSC 5PSD 5PSE 5PSF 5PSG 5PSH 5PSI 5PSJ 5PSK 5PSL 5PSM 5PSN 5PSO 5PSP 5PSQ 5PSR 5PSS 5PST 5PSU 5PSV 5PSW 5PSX 5PSY 5PSZ 5PT0 5PT1 5PT2 5PT3 5PT4 5PT5 5PT6 5PT7 5PT8 5PT9 5PTA 5PTB 5PTC 5PTE 5PTF 5PTG 5PTH 5PTJ 5PTK 5PTL 5PTM 5PTN 5PTO 5PTQ 5PTR 5PTS 5PTT 5PTU 5PTV 5PTW 5PTX 5PTY 5PTZ 5PU0 5PU1 5PU2 5PU3 5PU4 5PU5 5PU6 5PU7 5PU8 5PU9 5PUA 5PUB 5PUC 5PUD 5PUE 5PUF 5PUG 5PUH 5PUI 5PUJ 5PUK 5PUL 5PUM 5PUN 5PUO 5PUP 5PUQ 5PUR 5PUS 5PUT 5PUU 5PUV 5PUW 5PUX 5PUY 5PUZ 5PV0 5PV1 5PV2 5PV3 5PV4 5PV5 5PV6 5PV7 5PV8 5PV9 5PVA 5PVB 5PVC 5PVD 5PVE 5PVF 5PVG 5PVH 5PVI 5PVJ 5PVK 5PVL 5PVM 5PVN 5PVO 5PVP 5PVQ 5PVR 5PVS 5PVT 5PVU 5PVV 5PVW 5PVX 5PVY 5PVZ 5PW0 5PW1 5PW2 5PW3 5PW4 5PW5 5PW6 5PW7 5PW8 5PW9 5PWA 5PWB 6IN2 6MAJ 6MAK	1YDP 2AZM 2D31 2DYP 3SHV 3SQD 3SZM 3U3Z 6K1I 6K1J 6K1K
Enriched GO Terms of Interacting Partners?
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