ARFIP2 and ARL1

Data Source:
BioGRID (two hybrid, two hybrid, affinity chromatography technology)

		ARFIP2	ARL1
Description		ADP ribosylation factor interacting protein 2	ADP ribosylation factor like GTPase 1
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GO Annotations	Cellular Component	Ruffle Cytoplasm Cytosol Plasma Membrane Cell Cortex Trans-Golgi Network Membrane	Cytoplasm Golgi Apparatus Trans-Golgi Network Cytosol Trans-Golgi Network Membrane
	Molecular Function	Protein Binding GTP Binding Phospholipid Binding Protein Domain Specific Binding GTP-dependent Protein Binding Small GTPase Binding Identical Protein Binding Cadherin Binding Phosphatidylinositol-4-phosphate Binding Membrane Curvature Sensor Activity	GTPase Activity GTP Binding Enzyme Activator Activity Protein Domain Specific Binding Metal Ion Binding
	Biological Process	Intracellular Protein Transport Autophagy Small GTPase Mediated Signal Transduction Lamellipodium Assembly Actin Cytoskeleton Organization Ruffle Organization Regulation Of Arp2/3 Complex-mediated Actin Nucleation	Intracellular Protein Transport Golgi Organization Toxin Metabolic Process Vesicle-mediated Transport Activation Of Phospholipase D Activity Protein Localization To Golgi Apparatus Retrograde Transport, Endosome To Golgi
Pathways		Retrograde transport at the Trans-Golgi-Network	Retrograde transport at the Trans-Golgi-Network
Drugs			Guanosine-5'-Diphosphate
Diseases
GWAS		Malaria ( 31844061)	Lung cancer in never smokers ( 28604730) Response to methotrexate in juvenile idiopathic arthritis ( 24709693)
Interacting Genes		61 interacting genes: AGTRAP AKT1 APP ARF1 ARF3 ARF5 ARF6 ARFIP1 ARL1 BLOC1S2 C19orf25 CDKN2A CDR1 CEP63 CMTM5 CYTH3 DGAT2L6 DMAP1 DTNBP1 FADS6 FSD2 GOLGA2 GSG1 HAUS1 HGS ING5 ITGB3BP ITSN1 KRT15 KRT16 LNX1 LY6D MAL2 MIEF1 MIEF2 NDRG4 NRDE2 NUP62 PBX3 PKNOX2 PLP2 PPIF RAC1 RAC2 RAC3 REEP5 REL RND1 SCAMP1 SCAMP5 SDCBP SH3GLB1 SMG9 SNX1 SOCS2 STAT3 SYP TMEM255B TRIM54 TTPA USHBP1	8 interacting genes: ARFIP2 COPG2 DRD2 GCC1 GCC2 GOLGA1 GOLGA4 SCOC
Entrez ID		23647	400
HPRD ID		07209	04574
Ensembl ID		ENSG00000132254	ENSG00000120805
Uniprot IDs		A0A087X1E4 B4DUZ3 B4DXH2 P53365	B4DZG7 P40616
PDB IDs		1I49 1I4D 1I4L 1I4T 4DCN	1UPT 4DCN 5EE5 5J5C
Enriched GO Terms of Interacting Partners?
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