TRAM1 and SEC61B

Data Source:
HPRD (in vivo)

		TRAM1	SEC61B
Description		translocation associated membrane protein 1	SEC61 translocon subunit beta
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Integral Component Of Membrane Integral Component Of Endoplasmic Reticulum Membrane	Endoplasmic Reticulum Sec61 Translocon Complex Endoplasmic Reticulum Membrane Cytosol Membrane Integral Component Of Membrane Endoplasmic Reticulum Sec Complex Endoplasmic Reticulum Quality Control Compartment
	Molecular Function	Protein Binding Signaling Receptor Activity	RNA Binding Protein Binding Epidermal Growth Factor Binding
	Biological Process	Cotranslational Protein Targeting To Membrane SRP-dependent Cotranslational Protein Targeting To Membrane, Translocation Viral Process Protein Insertion Into ER Membrane	SRP-dependent Cotranslational Protein Targeting To Membrane, Translocation Ubiquitin-dependent ERAD Pathway Retrograde Protein Transport, ER To Cytosol Posttranslational Protein Targeting To Membrane, Translocation Regulation Of Catalytic Activity
Pathways		SRP-dependent cotranslational protein targeting to membrane	ER-Phagosome pathway SRP-dependent cotranslational protein targeting to membrane Insertion of tail-anchored proteins into the endoplasmic reticulum membrane Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
Drugs
Diseases
GWAS		Cardiac Troponin-T levels ( 23247143) Erythrocyte cadmium concentration in never smokers ( 27005419) Refractive error ( 32231278) Spherical equivalent or myopia (age of diagnosis) ( 29808027)	Adult body size ( 32376654) Asthma ( 31959851) Callous-unemotional behaviour ( 23874384) Gestational age at birth (maternal effect) ( 28877031) HDL cholesterol levels ( 32203549) Smoking status (ever vs never smokers) ( 30643258) Triglyceride levels ( 32203549)
Interacting Genes		12 interacting genes: APP CREB3 DRD2 ESR1 ESR2 GUCA2A SEC61B TICAM1 TIRAP TRAF6 UBC VKORC1	19 interacting genes: APOB ARL6 ATP13A2 AURKA BAG6 BMPR1A BUB1 CDKN2A FBXW7 GET3 GET4 MCC MLH3 MUTYH SEC63 SERP1 SPC25 TRAM1 UBL4A
Entrez ID		23471	10952
HPRD ID		05545	06715
Ensembl ID		ENSG00000067167	ENSG00000106803
Uniprot IDs		G3XAN4 Q15629 Q6FHL3	P60468
PDB IDs			6W6L
Enriched GO Terms of Interacting Partners?
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