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PTGS2 and COPS5
Data Source:
BioGRID
(pull down)
PTGS2
COPS5
Description
prostaglandin-endoperoxide synthase 2
COP9 signalosome subunit 5
Image
GO Annotations
Cellular Component
Nuclear Inner Membrane
Nuclear Outer Membrane
Cytoplasm
Endoplasmic Reticulum
Endoplasmic Reticulum Lumen
Endoplasmic Reticulum Membrane
Neuron Projection
Chromatin
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Eukaryotic Translation Initiation Factor 3 Complex
Synaptic Vesicle
COP9 Signalosome
Perinuclear Region Of Cytoplasm
Molecular Function
Peroxidase Activity
Prostaglandin-endoperoxide Synthase Activity
Protein Binding
Enzyme Binding
Heme Binding
Metal Ion Binding
Dioxygenase Activity
Transcription Coactivator Activity
Translation Initiation Factor Activity
Metalloendopeptidase Activity
Thiol-dependent Ubiquitin-specific Protease Activity
Protein Binding
Metallopeptidase Activity
NEDD8-specific Protease Activity
Enzyme Binding
Macrophage Migration Inhibitory Factor Binding
Metal Ion Binding
Isopeptidase Activity
Biological Process
Prostaglandin Biosynthetic Process
Inflammatory Response
Response To Oxidative Stress
Regulation Of Blood Pressure
Positive Regulation Of Vascular Endothelial Growth Factor Production
Cytokine-mediated Signaling Pathway
Cyclooxygenase Pathway
Lipoxygenase Pathway
Positive Regulation Of Prostaglandin Biosynthetic Process
Positive Regulation Of Fever Generation
NAD Biosynthesis Via Nicotinamide Riboside Salvage Pathway
Long-chain Fatty Acid Biosynthetic Process
Positive Regulation Of Nitric Oxide Biosynthetic Process
Regulation Of Inflammatory Response
Cellular Response To Hypoxia
Positive Regulation Of Transforming Growth Factor Beta Production
Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis
Positive Regulation Of Fibroblast Growth Factor Production
Positive Regulation Of Brown Fat Cell Differentiation
Positive Regulation Of Platelet-derived Growth Factor Production
Cellular Oxidant Detoxification
Regulation Of Neuroinflammatory Response
Protein Deneddylation
Nucleotide-excision Repair, DNA Damage Recognition
Transcription-coupled Nucleotide-excision Repair
Translation
Translational Initiation
Protein Deubiquitination
Protein Phosphopantetheinylation
Negative Regulation Of Apoptotic Process
Post-translational Protein Modification
Positive Regulation Of Transcription By RNA Polymerase II
Regulation Of JNK Cascade
Positive Regulation Of DNA-binding Transcription Factor Activity
Regulation Of Cell Cycle
Regulation Of IRE1-mediated Unfolded Protein Response
Exosomal Secretion
Pathways
Nicotinamide salvaging
Synthesis of 15-eicosatetraenoic acid derivatives
Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
Interleukin-10 signaling
Interleukin-4 and Interleukin-13 signaling
Biosynthesis of DHA-derived SPMs
Biosynthesis of EPA-derived SPMs
Biosynthesis of DPAn-3 SPMs
Biosynthesis of electrophilic ω-3 PUFA oxo-derivatives
DNA Damage Recognition in GG-NER
Formation of TC-NER Pre-Incision Complex
Cargo recognition for clathrin-mediated endocytosis
Neddylation
Drugs
Dihomo-gamma-linolenic acid
Icosapent
Aminosalicylic acid
Mesalazine
Acetaminophen
Indomethacin
Nabumetone
Ketorolac
Tenoxicam
Lenalidomide
Celecoxib
Tolmetin
Rofecoxib
Piroxicam
Fenoprofen
Valdecoxib
Diclofenac
Sulindac
Flurbiprofen
Etodolac
Mefenamic acid
Naproxen
Sulfasalazine
Phenylbutazone
Meloxicam
Carprofen
Diflunisal
Suprofen
Salicylic acid
Meclofenamic acid
Acetylsalicylic acid
Bromfenac
Oxaprozin
Ketoprofen
Balsalazide
Thalidomide
Ibuprofen
Lumiracoxib
Magnesium salicylate
Salsalate
Choline magnesium trisalicylate
Ginseng
Antrafenine
Antipyrine
Tiaprofenic acid
Etoricoxib
Flufenamic acid
Resveratrol
1-Phenylsulfonamide-3-Trifluoromethyl-5-Parabromophenylpyrazole
Prostaglandin G2
Niflumic acid
Licofelone
Nimesulide
Cimicoxib
Lornoxicam
Aceclofenac
Nepafenac
Parecoxib
Pomalidomide
Cannabidiol
Loxoprofen
Dexibuprofen
Dexketoprofen
Droxicam
Tolfenamic acid
Firocoxib
Morniflumate
Propacetamol
Talniflumate
Phenyl salicylate
Trolamine salicylate
Menthyl salicylate
Glycol salicylate
Dipyrithione
Bryostatin 1
Alclofenac
Bufexamac
Bendazac
Acemetacin
Fish oil
Medical Cannabis
Nabiximols
Diseases
Esophageal cancer
Cholangiocarcinoma
Penile cancer
GWAS
Crohn's disease (
26192919
)
Inflammatory bowel disease (
26192919
)
Knee osteoarthritis (
18471798
)
Interacting Genes
13 interacting genes:
ABHD16A
CASK
CAV1
CELF2
COPS5
COPS7A
CTNNB1
ELAVL1
GAS5
NUCB1
PTGIS
TP53
USP22
98 interacting genes:
APCS
ARFGAP1
ATM
ATRN
BCL2L14
BCL3
BRD4
BRSK2
CACNA1C
CD274
CD93
CDKN1B
CENPT
CHUK
COPS2
COPS3
COPS4
COPS6
COPS7A
COPS7B
COPS8
COPS9
CUL1
CUL2
CUL3
CUL4A
CUL5
DDB1
DDO
ERN1
ERRFI1
ESR1
F2RL1
GFER
GFI1B
GPS1
GTPBP3
HAND2
HIF1A
HNF4A
HNF4G
HTR6
ITGB2
JUN
JUND
LASP1
MAP2K2
MAP3K11
MAP3K3
MAP3K7
MAP4K3
MAP4K5
MAPK14
MAPRE1
MAX
MDC1
MDM2
MEF2C
MEF2D
MIF
MTRES1
MYG1
NCOA1
NEDD8
NFKB1
NR4A2
NR4A3
OPRM1
PEA15
PGR
PLAC8
PPARG
PPOX
PPP1CC
PRDX2
PRKD1
PTGS2
RAD1
RAD9A
RNF139
RORA
S100A7
SHANK3
SHISA5
SMAD2
SMAD4
SMAD5
SPP1
SREBF2
TOP2A
TP53
TXN
TYK2
UCHL1
USP14
VTN
WNK1
YWHAG
Entrez ID
5743
10987
HPRD ID
02599
06888
Ensembl ID
ENSG00000073756
ENSG00000121022
Uniprot IDs
P35354
A0A024R7W9
Q92905
PDB IDs
1V0X
5F19
5F1A
5IKQ
5IKR
5IKT
5IKV
5KIR
4D10
4D18
4F7O
4WSN
5JOG
5JOH
5M5Q
6R6H
6R7F
6R7H
6R7I
Enriched GO Terms of Interacting Partners
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