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CD274 and COPS5
Data Source:
BioGRID
(enzymatic study)
CD274
COPS5
Description
CD274 molecule
COP9 signalosome subunit 5
Image
GO Annotations
Cellular Component
Nucleoplasm
Plasma Membrane
External Side Of Plasma Membrane
Actin Cytoskeleton
Integral Component Of Membrane
Early Endosome Membrane
Recycling Endosome Membrane
Extracellular Exosome
Chromatin
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Eukaryotic Translation Initiation Factor 3 Complex
Synaptic Vesicle
COP9 Signalosome
Perinuclear Region Of Cytoplasm
Molecular Function
Protein Binding
Transcription Coactivator Activity
Translation Initiation Factor Activity
Metalloendopeptidase Activity
Thiol-dependent Ubiquitin-specific Protease Activity
Protein Binding
Metallopeptidase Activity
NEDD8-specific Protease Activity
Enzyme Binding
Macrophage Migration Inhibitory Factor Binding
Metal Ion Binding
Isopeptidase Activity
Biological Process
Adaptive Immune Response
Positive Regulation Of Tolerance Induction To Tumor Cell
Immune Response
Signal Transduction
Cell Surface Receptor Signaling Pathway
Positive Regulation Of Cell Migration
T Cell Costimulation
Negative Regulation Of Interferon-gamma Production
Negative Regulation Of Interleukin-10 Production
Positive Regulation Of Interleukin-10 Production
Response To Cytokine
Positive Regulation Of T Cell Proliferation
Negative Regulation Of T Cell Proliferation
Regulation Of Activated T Cell Proliferation
Negative Regulation Of Activated T Cell Proliferation
Regulation Of T Cell Apoptotic Process
Cellular Response To Lipopolysaccharide
Toxin Transport
Negative Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production
Regulation Of Activated CD4-positive, Alpha-beta T Cell Apoptotic Process
Positive Regulation Of Activated CD8-positive, Alpha-beta T Cell Apoptotic Process
Negative Regulation Of CD4-positive, Alpha-beta T Cell Proliferation
Negative Regulation Of CD8-positive, Alpha-beta T Cell Activation
Protein Deneddylation
Nucleotide-excision Repair, DNA Damage Recognition
Transcription-coupled Nucleotide-excision Repair
Translation
Translational Initiation
Protein Deubiquitination
Protein Phosphopantetheinylation
Negative Regulation Of Apoptotic Process
Post-translational Protein Modification
Positive Regulation Of Transcription By RNA Polymerase II
Regulation Of JNK Cascade
Positive Regulation Of DNA-binding Transcription Factor Activity
Regulation Of Cell Cycle
Regulation Of IRE1-mediated Unfolded Protein Response
Exosomal Secretion
Pathways
PD-1 signaling
DNA Damage Recognition in GG-NER
Formation of TC-NER Pre-Incision Complex
Cargo recognition for clathrin-mediated endocytosis
Neddylation
Drugs
Atezolizumab
Durvalumab
Avelumab
Envafolimab
Cosibelimab
AUNP-12
CA-170
anti-OX40 antibody BMS 986178
Diseases
GWAS
Blood protein levels (
30072576
)
Interacting Genes
4 interacting genes:
CD80
COPS5
PDCD1
USP22
98 interacting genes:
APCS
ARFGAP1
ATM
ATRN
BCL2L14
BCL3
BRD4
BRSK2
CACNA1C
CD274
CD93
CDKN1B
CENPT
CHUK
COPS2
COPS3
COPS4
COPS6
COPS7A
COPS7B
COPS8
COPS9
CUL1
CUL2
CUL3
CUL4A
CUL5
DDB1
DDO
ERN1
ERRFI1
ESR1
F2RL1
GFER
GFI1B
GPS1
GTPBP3
HAND2
HIF1A
HNF4A
HNF4G
HTR6
ITGB2
JUN
JUND
LASP1
MAP2K2
MAP3K11
MAP3K3
MAP3K7
MAP4K3
MAP4K5
MAPK14
MAPRE1
MAX
MDC1
MDM2
MEF2C
MEF2D
MIF
MTRES1
MYG1
NCOA1
NEDD8
NFKB1
NR4A2
NR4A3
OPRM1
PEA15
PGR
PLAC8
PPARG
PPOX
PPP1CC
PRDX2
PRKD1
PTGS2
RAD1
RAD9A
RNF139
RORA
S100A7
SHANK3
SHISA5
SMAD2
SMAD4
SMAD5
SPP1
SREBF2
TOP2A
TP53
TXN
TYK2
UCHL1
USP14
VTN
WNK1
YWHAG
Entrez ID
29126
10987
HPRD ID
05655
06888
Ensembl ID
ENSG00000120217
ENSG00000121022
Uniprot IDs
Q0GN75
Q9NZQ7
A0A024R7W9
Q92905
PDB IDs
3BIK
3BIS
3FN3
3SBW
4Z18
4ZQK
5C3T
5GGT
5GRJ
5IUS
5J89
5J8O
5JDR
5JDS
5N2D
5N2F
5NIU
5O45
5O4Y
5X8L
5X8M
5XJ4
5XXY
6NM7
6NM8
6NNV
6NOJ
6NOS
6NP9
6PV9
6R3K
6RPG
4D10
4D18
4F7O
4WSN
5JOG
5JOH
5M5Q
6R6H
6R7F
6R7H
6R7I
Enriched GO Terms of Interacting Partners
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