RALA and PLCD1

Data Source:
BioGRID (pull down)
HPRD (two hybrid, in vitro)

		RALA	PLCD1
Description		RAS like proto-oncogene A	phospholipase C delta 1
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Focal Adhesion Cell Surface Endocytic Vesicle Cytoplasmic Vesicle Membrane Cleavage Furrow Extracellular Exosome Flemming Body	Cytoplasm Plasma Membrane Extracellular Exosome
	Molecular Function	GTPase Activity Protein Binding GTP Binding Myosin Binding GDP Binding Ubiquitin Protein Ligase Binding Edg-2 Lysophosphatidic Acid Receptor Binding ATPase Binding	Phosphatidylserine Binding Phosphatidylinositol Phospholipase C Activity Calcium Ion Binding Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding GTPase Activating Protein Binding Phosphatidic Acid Binding
	Biological Process	Neural Tube Closure Exocytosis Chemotaxis Cell Cycle Signal Transduction Ras Protein Signal Transduction Regulation Of Exocytosis Actin Cytoskeleton Reorganization Interleukin-12-mediated Signaling Pathway Cell Division Positive Regulation Of Filopodium Assembly Membrane Raft Localization Membrane Organization	Phospholipid Metabolic Process Lipid Catabolic Process Inositol Phosphate Metabolic Process Phosphatidylinositol Metabolic Process Phosphatidylinositol-mediated Signaling
Pathways		Translocation of SLC2A4 (GLUT4) to the plasma membrane p38MAPK events Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	Synthesis of IP3 and IP4 in the cytosol
Drugs		Guanosine-5'-Diphosphate	1D-myo-inositol 1,4,5-trisphosphate Inositol 2,4,5-trisphosphate
Diseases
GWAS
Interacting Genes		30 interacting genes: ARF1 CALM1 CNKSR2 CTCF EXOC1 EXOC2 EXOC3 EXOC4 EXOC5 EXOC6B EXOC7 EXOC8 FLNA GLS2 HSPB1 LSM2 PIH1D2 PLCD1 PLD1 PPP2R1B RAB34 RAB8B RALBP1 RALGPS1 RASSF5 REPS1 RGL2 RGL4 SMAD4 YBX3	10 interacting genes: APP CALM1 GAP43 HGS KPNB1 NTAQ1 PAXIP1 RALA RALB TGM2
Entrez ID		5898	5333
HPRD ID		01549	09073
Ensembl ID		ENSG00000006451	ENSG00000187091
Uniprot IDs		P11233	A0A384MR47 A8K8F9 P51178
PDB IDs		1UAD 1ZC3 1ZC4 2A78 2A9K 2BOV 6P0I 6P0J 6P0K 6P0L 6P0M 6P0N 6P0O
Enriched GO Terms of Interacting Partners?
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