KIF1B and DLG1

Data Source:
HPRD (in vitro, two hybrid, in vivo)

		KIF1B	DLG1
Description		kinesin family member 1B	discs large MAGUK scaffold protein 1
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GO Annotations	Cellular Component	Mitochondrion Kinesin Complex Microtubule Microtubule Associated Complex Synaptic Vesicle Axon Dendrite Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Neuron Projection Axon Cytoplasm	Immunological Synapse Basement Membrane Nucleus Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Microtubule Plasma Membrane Cell-cell Junction Bicellular Tight Junction Ionotropic Glutamate Receptor Complex Cytoplasmic Side Of Plasma Membrane Intercalated Disc Basolateral Plasma Membrane Apical Plasma Membrane Lateral Plasma Membrane Cell Junction Cell Projection Membrane Neuromuscular Junction Node Of Ranvier Myelin Sheath Abaxonal Region Sarcolemma Neuron Projection Lateral Loop Membrane Raft Perinuclear Region Of Cytoplasm Extracellular Exosome MPP7-DLG1-LIN7 Complex Synaptic Membrane Postsynaptic Density Membrane Glutamatergic Synapse
	Molecular Function	Microtubule Motor Activity Protein Binding ATP Binding Microtubule Binding ATP-dependent Microtubule Motor Activity, Plus-end-directed ATPase Activity Kinesin Binding Kinase Binding Scaffold Protein Binding	Guanylate Kinase Activity Phosphoprotein Phosphatase Activity Protein Binding Protein C-terminus Binding Cytoskeletal Protein Binding Potassium Channel Regulator Activity Protein Kinase Binding Phosphatase Binding Mitogen-activated Protein Kinase Kinase Binding Ion Channel Binding Cadherin Binding Molecular Adaptor Activity L27 Domain Binding Structural Constituent Of Postsynaptic Density
	Biological Process	Apoptotic Process Microtubule-based Movement Neuron-neuron Synaptic Transmission Neuromuscular Synaptic Transmission Anterograde Axonal Transport Positive Regulation Of Gene Expression Vesicle-mediated Transport Cytoskeleton-dependent Intracellular Transport Lysosome Localization Response To Rotenone Anterograde Neuronal Dense Core Vesicle Transport Retrograde Neuronal Dense Core Vesicle Transport Cellular Response To Nerve Growth Factor Stimulus Protein Localization To Cell Periphery	Negative Regulation Of Transcription By RNA Polymerase II MAPK Cascade Branching Involved In Ureteric Bud Morphogenesis Immunological Synapse Formation Endothelial Cell Proliferation Lens Development In Camera-type Eye Protein Dephosphorylation Actin Filament Organization Establishment Or Maintenance Of Cell Polarity Chemical Synaptic Transmission Positive Regulation Of Cell Population Proliferation Regulation Of Cell Shape Embryo Development Viral Process Peristalsis Positive Regulation Of Actin Filament Polymerization Cortical Actin Cytoskeleton Organization Astral Microtubule Organization Membrane Raft Organization Regulation Of Myelination Activation Of Protein Kinase Activity Cellular Protein-containing Complex Localization T Cell Activation Negative Regulation Of T Cell Proliferation Regulation Of Membrane Potential Amyloid Precursor Protein Metabolic Process Receptor Clustering Positive Regulation Of Potassium Ion Transport Cortical Microtubule Organization Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity GMP Metabolic Process GDP Metabolic Process Reproductive Structure Development Embryonic Skeletal System Morphogenesis Smooth Muscle Tissue Development Negative Regulation Of Epithelial Cell Proliferation Establishment Of Centrosome Localization Negative Regulation Of Protein Kinase B Signaling Hard Palate Development Negative Regulation Of ERK1 And ERK2 Cascade Bicellular Tight Junction Assembly Protein Localization To Plasma Membrane Receptor Localization To Synapse Cell-cell Adhesion Regulation Of Ventricular Cardiac Muscle Cell Action Potential Maintenance Of Postsynaptic Density Structure Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Regulation Of NIK/NF-kappaB Signaling Regulation Of Sodium Ion Transmembrane Transport Regulation Of Protein Localization To Synapse Positive Regulation Of Protein Localization To Plasma Membrane Regulation Of Potassium Ion Import Negative Regulation Of P38MAPK Cascade Regulation Of Voltage-gated Potassium Channel Activity Involved In Ventricular Cardiac Muscle Cell Action Potential Repolarization Regulation Of Potassium Ion Export Across Plasma Membrane Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of NMDA Receptor Activity
Pathways		COPI-dependent Golgi-to-ER retrograde traffic Kinesins	Trafficking of AMPA receptors Unblocking of NMDA receptors, glutamate binding and activation Unblocking of NMDA receptors, glutamate binding and activation Ras activation upon Ca2+ influx through NMDA receptor NrCAM interactions Activation of Ca-permeable Kainate Receptor RAF/MAP kinase cascade Synaptic adhesion-like molecules Assembly and cell surface presentation of NMDA receptors Negative regulation of NMDA receptor-mediated neuronal transmission Long-term potentiation
Drugs
Diseases		Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy
GWAS		Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Hand grip strength ( 29691431) Hematocrit ( 27863252) Hepatitis B virus-related hepatocellular carcinoma ( 29246937) Hepatocellular carcinoma ( 20676096) Lateral orbital frontal cortex volume ( 31530798) Mean platelet volume ( 22139419 32888494 27863252) Monocyte percentage of white cells ( 32888494) Multiple sclerosis ( 18997785) Neutrophil count ( 32888494) Platelet count ( 32888494) Virologic severity in Herpes simplex virus type 2 infection ( 29535370) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in non-smokers ( 28443625) White blood cell count ( 32888494)	Allergic rhinitis ( 25085501) Diastolic blood pressure ( 30224653) Heel bone mineral density ( 30598549) Metabolite levels ( 23823483) PR interval ( 32439900)
Interacting Genes		22 interacting genes: ARHGAP1 BRCA1 CALM1 CHP1 CLIP4 CPEB1 DLG1 DLG2 DLG3 DLG4 DYSF EEF1A1 GIPC1 LAMTOR5 PATJ PGM1 POMP SIAH1 SNTA1 STARD13 TRIM55 YWHAG	75 interacting genes: ACTA1 ACTN2 ADAM17 ADGRA2 ADGRA3 ADGRB1 ADRB1 AKAP5 ATP2B2 ATP2B4 BCR BEGAIN CACNG2 CALM2 CAMK2A CASK CNKSR2 CRHR1 CRIPT CTNNA1 DLG2 DLG3 DLGAP1 DLGAP3 DLGAP4 EPB41 ERBB4 EZR FZD4 FZD7 GDA GLS2 GNG13 GRIA1 GRIK2 GRIN1 GRIN2A GRIN2B GUCY1A2 HTR2A KCNA1 KCNA2 KCNA3 KCNA4 KCNA5 KCNAB1 KCNJ10 KCNJ12 KCNJ2 KCNJ4 KCNJ6 KHDRBS1 KIF13B KIF1B LCK LRP2 LRRC1 MAP1A MAPK12 MPP2 MRPS34 MYO6 PAX6 PBK PRKN PTEN SCN4A SCN5A SEMA4C STX4 TANC1 TJAP1 UBE3A WAS WNT3A
Entrez ID		23095	1739
HPRD ID		05818	03007
Ensembl ID		ENSG00000054523	ENSG00000075711
Uniprot IDs		O60333	A0A0C4DFT3 A0A590UJ08 B4DF78 Q12959
PDB IDs		2EH0	1PDR 2M3M 2OQS 2X7Z 3LRA 3RL7 3RL8 3W9Y 4AMH 4G69
Enriched GO Terms of Interacting Partners?
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