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MAPKBP1 and PLA2G10
Data Source:
BioGRID
(two hybrid)
MAPKBP1
PLA2G10
Description
mitogen-activated protein kinase binding protein 1
phospholipase A2 group X
Image
No pdb structure
GO Annotations
Cellular Component
Nucleoplasm
Nucleolus
Cytoplasm
Mitotic Spindle Pole
Acrosomal Vesicle
Extracellular Region
Extracellular Space
Lysosome
Molecular Function
Protein Binding
1-alkyl-2-acetylglycerophosphocholine Esterase Activity
Phospholipase Activity
Phospholipase A2 Activity
Calcium Ion Binding
Protein Binding
Phospholipid Binding
Calcium-dependent Phospholipase A2 Activity
Phospholipase A2 Activity (consuming 1,2-dipalmitoylphosphatidylcholine)
Phospholipase A2 Activity Consuming 1,2-dioleoylphosphatidylethanolamine)
Biological Process
Negative Regulation Of Interleukin-8 Production
Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Negative Regulation Of Defense Response To Bacterium
Phospholipid Metabolic Process
Phosphatidic Acid Biosynthetic Process
Phosphatidylserine Metabolic Process
Axon Guidance
Positive Regulation Of Macrophage Derived Foam Cell Differentiation
Positive Regulation Of Lipid Storage
Arachidonic Acid Metabolic Process
Positive Regulation Of Cellular Protein Metabolic Process
Positive Regulation Of Prostaglandin Secretion
Low-density Lipoprotein Particle Remodeling
Phosphatidylcholine Catabolic Process
Phosphatidylglycerol Acyl-chain Remodeling
Phosphatidylinositol Acyl-chain Remodeling
Phosphatidylserine Acyl-chain Remodeling
Phosphatidylcholine Acyl-chain Remodeling
Phosphatidylethanolamine Acyl-chain Remodeling
Cholesterol Homeostasis
Regulation Of Macrophage Activation
Negative Regulation Of DNA-binding Transcription Factor Activity
Phosphatidylethanolamine Metabolic Process
Phosphatidylcholine Metabolic Process
Phosphatidylglycerol Metabolic Process
Phosphatidic Acid Metabolic Process
Arachidonic Acid Secretion
Defense Response To Virus
Lysophospholipid Transport
Platelet Activating Factor Catabolic Process
Positive Regulation Of Arachidonic Acid Secretion
Negative Regulation Of Cholesterol Efflux
Positive Regulation Of Acrosome Reaction
Pathways
Acyl chain remodelling of PC
Acyl chain remodelling of PS
Acyl chain remodelling of PE
Acyl chain remodelling of PI
Acyl chain remodelling of PG
Synthesis of PA
Drugs
Varespladib methyl
Crotalus adamanteus antivenin
Agkistrodon piscivorus antivenin
Diseases
GWAS
Diastolic blood pressure (
27841878
)
Urinary albumin excretion (
30220432
)
Waist-to-hip ratio adjusted for BMI (additive genetic model) (
30778226
)
Cholesteryl ester levels (
31551469
)
Glycerophospholipid levels (
26068415
)
Interacting Genes
62 interacting genes:
ADAM12
ADAMTSL4
ALG13
APTX
CTDSP1
CYSRT1
FOXN1
GLRX3
HOXA1
KEAP1
KPRP
KRT31
KRT34
KRT35
KRT38
KRT40
KRT86
KRTAP1-1
KRTAP1-3
KRTAP10-1
KRTAP10-3
KRTAP10-7
KRTAP10-8
KRTAP10-9
KRTAP12-3
KRTAP13-1
KRTAP26-1
KRTAP3-1
KRTAP3-2
KRTAP4-12
KRTAP5-6
KRTAP5-7
KRTAP5-9
KRTAP6-3
KRTAP9-2
KRTAP9-3
KRTAP9-4
MAPK10
MAPK8
MAPK9
MDFI
MEOX2
METTL15
MYOG
NBPF19
NOTCH2NLA
PLA2G10
PLSCR3
RBCK1
RGS20
SIAH1
SPRY2
SPRY3
TCF12
TCF4
TEKT5
TEX11
TRIM27
TRIM42
TRIP6
YPEL5
ZNF34
49 interacting genes:
AGXT
AQP1
ARID5A
ATXN1
BAG3
BEX2
C1orf94
CATSPER1
CCDC120
CREB5
CYSRT1
FAM222B
FOXH1
GATA5
GNE
HGS
HOXC8
HR
HSF4
INCA1
KPRP
KRTAP11-1
KRTAP26-1
LCE1A
LCE1C
LCE2A
LCE2B
LCE2D
MAL
MAPKBP1
MGAT5B
MYO10
NOXA1
NTAQ1
OTX1
PITX1
PLA2R1
POU4F3
PPP1R32
ROR2
SNRPC
SPAG8
STK16
TBX6
TFG
TLX3
VGLL3
VPS37C
ZC3H10
Entrez ID
23005
8399
HPRD ID
17465
04674
Ensembl ID
ENSG00000137802
ENSG00000069764
Uniprot IDs
O60336
O15496
PDB IDs
1LE6
1LE7
4UY1
5G3M
5OW8
5OWC
6G5J
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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