ARRDC1 and PDCD6IP

Data Source:
BioGRID (two hybrid, two hybrid)

		ARRDC1	PDCD6IP
Description		arrestin domain containing 1	programmed cell death 6 interacting protein
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Cytoplasmic Vesicle Extracellular Exosome Extracellular Vesicle	Immunological Synapse Microtubule Organizing Center Cytosol Bicellular Tight Junction Focal Adhesion Membrane Melanosome Actomyosin Intracellular Membrane-bounded Organelle Extracellular Exosome Endoplasmic Reticulum Exit Site Flemming Body Extracellular Vesicle
	Molecular Function	Protein Binding Ubiquitin Protein Ligase Binding Identical Protein Binding Ubiquitin Ligase-substrate Adaptor Activity Arrestin Family Protein Binding	Protein Binding Proteinase Activated Receptor Binding Protein Homodimerization Activity Calcium-dependent Protein Binding
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Extracellular Transport Protein Transport Protein Ubiquitination Negative Regulation Of Notch Signaling Pathway Extracellular Vesicle Biogenesis	Mitotic Cytokinesis Actomyosin Contractile Ring Assembly Apoptotic Process Nucleus Organization Mitotic Metaphase Plate Congression Regulation Of Centrosome Duplication Protein Transport Viral Life Cycle Multivesicular Body Assembly Viral Budding Via Host ESCRT Complex Maintenance Of Epithelial Cell Apical/basal Polarity Viral Budding Protein Homooligomerization Midbody Abscission Bicellular Tight Junction Assembly Regulation Of Membrane Permeability Ubiquitin-independent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Regulation Of Mitotic Spindle Assembly Positive Regulation Of Exosomal Secretion Regulation Of Extracellular Exosome Assembly Positive Regulation Of Extracellular Exosome Assembly
Pathways			Budding and maturation of HIV virion Uptake and function of anthrax toxins RIPK1-mediated regulated necrosis Regulation of necroptotic cell death
Drugs
Diseases
GWAS		Asthma ( 32296059) Asthma (age of onset) ( 31036433) Asthma (childhood onset) ( 31036433)	Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) ( 28090653) Neuroticism ( 27089181) Periodontitis (Mean PAL) ( 24024966) Rosacea symptom severity ( 29771307) Severe influenza A (H1N1) infection ( 26379185) Smoking status (ever vs never smokers) ( 30643258) Visceral adipose tissue adjusted for BMI ( 22589738) White coat effect (clinic diastolic blood pressure minus ambulatory diastolic blood pressure) ( 31044621)
Interacting Genes		11 interacting genes: APP DAPK1 EPN2 KLHL12 MTDH MTURN PDCD6IP TSG101 UBASH3A WWP1 WWP2	36 interacting genes: ARRDC1 ARRDC3 ATN1 CD2AP CEP55 CHMP4A CHMP4B CHMP4C CXCR1 DRD1 EGFR F2R GRB2 ITSN1 ITSN2 KEAP1 MAPK6 PDCD6 PTK2B RAMP3 RNF11 SDCBP SH3GL1 SH3GL2 SH3GL3 SH3KBP1 SH3RF1 SRC SUMO2 TAB1 TSG101 TTF2 UBC VPS28 VPS37C YES1
Entrez ID		92714	10015
HPRD ID		12491	06425
Ensembl ID		ENSG00000197070	ENSG00000170248
Uniprot IDs		Q8N5I2	Q8WUM4
PDB IDs			2OEV 2OEW 2OEX 2OJQ 2R02 2R03 2R05 2XS1 2XS8 2ZNE 3C3O 3C3Q 3C3R 3E1R 3WUV 4JJY 5V3R 5WA1 6KP3
Enriched GO Terms of Interacting Partners?
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