DIS3 and EXOSC10

Data Source:
BioGRID (biochemical)
HPRD (two hybrid)

		DIS3	EXOSC10
Description		DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease	exosome component 10
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GO Annotations	Cellular Component	Nuclear Exosome (RNase Complex) Cytoplasmic Exosome (RNase Complex) Exosome (RNase Complex) Nucleoplasm Nucleolus Cytosol Membrane	Nuclear Exosome (RNase Complex) Exosome (RNase Complex) Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Membrane Transcriptionally Active Chromatin
	Molecular Function	3'-5'-exoribonuclease Activity RNA Binding Endonuclease Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding	Nucleotide Binding 3'-5'-exoribonuclease Activity RNA Binding Single-stranded RNA Binding Exoribonuclease Activity Protein Binding Telomerase RNA Binding
	Biological Process	RRNA Processing RRNA Catabolic Process Regulation Of MRNA Stability Exonucleolytic Catabolism Of Deadenylated MRNA Regulation Of Catalytic Activity CUT Catabolic Process RNA Phosphodiester Bond Hydrolysis, Exonucleolytic	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Maturation Of 5.8S RRNA Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Nuclear-transcribed MRNA Catabolic Process RRNA Processing Dosage Compensation By Inactivation Of X Chromosome Negative Regulation Of Telomere Maintenance Via Telomerase Nuclear MRNA Surveillance CUT Catabolic Process Nuclear Polyadenylation-dependent RRNA Catabolic Process Nuclear Polyadenylation-dependent SnoRNA Catabolic Process Nuclear Polyadenylation-dependent SnRNA Catabolic Process Nuclear Polyadenylation-dependent TRNA Catabolic Process Nuclear Polyadenylation-dependent CUT Catabolic Process Nuclear Polyadenylation-dependent Antisense Transcript Catabolic Process Histone MRNA Catabolic Process Nuclear Retention Of Unspliced Pre-mRNA At The Site Of Transcription Polyadenylation-dependent SnoRNA 3'-end Processing Regulation Of Telomerase RNA Localization To Cajal Body
Pathways		ATF4 activates genes in response to endoplasmic reticulum stress mRNA decay by 3' to 5' exoribonuclease Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA KSRP (KHSRP) binds and destabilizes mRNA Major pathway of rRNA processing in the nucleolus and cytosol	Major pathway of rRNA processing in the nucleolus and cytosol
Drugs
Diseases
GWAS		Restless legs syndrome ( 29029846)	Beard thickness ( 26926045) Heel bone mineral density ( 30598549) Intraocular pressure ( 29617998)
Interacting Genes		12 interacting genes: EXOSC10 EXOSC2 EXOSC4 EXOSC5 EXOSC6 EXOSC7 EXOSC8 EXOSC9 MTREX NTMT1 PALS2 ZBTB17	37 interacting genes: ALDH1B1 B9D1 CHPF CIB1 DIS3 DXO EIF3M EXOSC4 EXOSC5 EXOSC6 EXOSC7 EXOSC8 FERMT3 FOXRED1 IMMT LCAT LSM2 LSM8 MPHOSPH6 NOMO1 NOMO2 PALS2 PTGES2 RPE RUVBL2 SCRIB SKIV2L SSRP1 SUMO2 TARDBP TOX4 TTN UPF2 USP16 USP21 XRN1 XRN2
Entrez ID		22894	5394
HPRD ID		06338	16180
Ensembl ID		ENSG00000083520	ENSG00000171824
Uniprot IDs		G3V1J5 Q9Y2L1	Q01780
PDB IDs		6D6Q 6D6R 6H25	2CPR 3SAF 3SAG 3SAH 6D6Q 6D6R
Enriched GO Terms of Interacting Partners?
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